Free radicals and Dupuytren's contracture

Duthie, Robert B.; Francis, M. J. O.

doi:10.1302/0301-620x.70b5.2848038

Cited by 5 publications

(4 citation statements)

References 3 publications

(3 reference statements)

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“…Murrell et al [65][66][67][68] introduced the free radical theory, which suggests a relation between localised ischaemia, superoxide free radicals (O 2 -), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH -) and Dupuytren's contracture. This was based on studies suggesting that microvessel narrowing secondary to age, smoking and other environmental factors leads to localised hypoxic conditions.…”

Section: Free Radicalsmentioning

confidence: 99%

New insights in the development of Dupuytren’s contracture: a review

Kloen¹

1999

British Journal of Plastic Surgery

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Section: Free Radicalsmentioning

confidence: 99%

New insights in the development of Dupuytren’s contracture: a review

Kloen¹

1999

British Journal of Plastic Surgery

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“…The role of ROS in DD pathogenesis has already been suggested 14, 15. We detected increased levels of isocytrate dehydrogenase 1 (IDH1), directly involved in the maintenance of the cellular redox state 16; alpha‐crystalin B chain (CRYAB), important in the cellular adaptation to environmental stress 17; and calreticulin (CALR), an endoplasmic reticulum stress protein with the ability to block oxidative stress.…”

Section: Resultsmentioning

confidence: 86%

An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren's disease

Pavelić

Sedić

Hock

et al. 2008

The Journal of Pathology

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Dupuytren's disease (DD) is a fibromatosis characterized by non-malignant transformation of palmar fascia leading to permanent contraction of one or more fingers. Despite the extensive knowledge of its clinical pathogenesis, the aetiology of this disease remains obscure. In the present paper, we report for the first time on the proteomic profiling of diseased versus unaffected patient-matched palmar fasciae tissues from DD patients using two-dimensional gel electrophoresis coupled with mass spectrometry analysis. The herein identified proteins were then used to create the protein-protein interaction network (interactome). Such an integrated approach revealed the involvement of several different molecular processes related to DD progression, including extra- and intra-cellular signalling, oxidative stress, cytoskeletal changes, and alterations in cellular metabolism. In particular, autocrine regulation through ERBB-2 and IGF-1R receptors and the Akt signalling pathway have emerged as novel components of pro-survival signalling in Dupuytren's fibroblasts and thus might provide a basis for a new therapeutic strategy in Dupuytren's disease.

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“…The correlation between Dupuytren's disease and occupation, mainly vibration and manual work, is still debatable [20-22]. Other etiologic mechanisms that have been implicated include free radicals [23], autoimmune [24] and neoplasia [25]. …”

Section: Etiologymentioning

confidence: 99%

Dupuytren's Disease: Review of the Current Literature

Khashan

Smitham²,

Khan³

et al. 2011

TOORHTJ

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Dupuytren’s disease is one of the most common condition seen by hand surgeons. It is not only prevalent but can also be a most debilitating condition resulting in significant loss of function of the fingers involved. The cause of this disease, however still remains largely unknown although some recent evidence suggests a stem cell etiology. This review article summarizes the current known knowledge of Dupuytren’s as well as the clinical findings, investigations and treatments available.

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Free radicals and Dupuytren's contracture

Abstract: 12 Ravussin E, Bogardus C, Schwartz RS, et al. Thermic effect ofinfused glucose and insulin in man:decreased response with increased insulin resistance in obesity and noninsulin dependent diabetes mellitus.

Cited by 5 publications

References 3 publications

New insights in the development of Dupuytren’s contracture: a review

New insights in the development of Dupuytren’s contracture: a review

An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren's disease

Dupuytren's Disease: Review of the Current Literature

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