Free radical scavenging and antiepileptic activity of Leucas lanata

Ramalingam, R. S.; Nath, Anisetti Ravinder; Madhavi, B. Bindu; Nagulu, Malothu; Balasubramaniam, A. S.

doi:10.1016/j.jopr.2013.03.011

Cited by 21 publications

(30 citation statements)

References 27 publications

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“…*, Acanthaceae Asthma, bronchitis, cough and rheumatism (Sharma and Sood, 2013) Pyrroquinazoline alkaloids (vasicine, vasicol, vasicinone, peganine along with minor alkaloids including adhatonine, vasicinol, vasicinolone), kaempferol, quercetin, β-sitosterol, β-glucosidegalactose and deoxy vasicine (Ahmad et al, 2009) Lepidagathis cuspidata Nees, Acanthaceae Painful inflammations of fingers (Thakur and Sidhu, 2014) Flavonoids, glycosides, phlobatannins, steroids, tannins and alkaloids (Thakur and Sidhu, 2014) Leucas lanata Benth., Lamiaceae Antibacterial, free radical scavenging, anti epileptic, antiparkinson, cure cold, cough, dysentery, wound, stomachache, headache, whooping cough and antidote for reptile poison (Verma and Chauhan, 2007;Singh, 2008;Unani et al, 2009;Nazir et al, 2010;Ramalingam et al, 2013a;Ramalingam et al, 2013b; Gallic acid, protocatechuic acid, chlorogenic acid, caffeic acid and ferulic acid (Dixit et al, 2015) Micromeria biflora (Buch.-Ham. ex D. Don) Benth., Lamiaceae Toothache, stomachache, cough, cold, fever, nose bleeding, wounds and sinusitis (Singh and Kumar, 2000;Manandhar, 1995;Manandhar, 2002) Essential oil rich in oxygenated sesquiterpenoids (caryophyllene oxide, epi-α-cadinol, β-eudesmol, oplapanone and guaial); oxygenated monoterpene (α-terpeneol); mono and sequiterpene hydrocarbons (α-cadinene, γ-cadinene, δ-cadinene, þ-cymene) (Chandra et al, 2013) Murraya koenigii (L.) Spreng.…”

Section: Justicia Adhatodamentioning

confidence: 99%

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Thakur

Asrani

Thakur

et al. 2016

Journal of Ethnopharmacology

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Section: Justicia Adhatodamentioning

confidence: 99%

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Thakur

Asrani

Thakur

et al. 2016

Journal of Ethnopharmacology

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“…Recently, similar results were published for extracts of L. aspera , L. martinicensis , and L. lanata [40–42]. It was shown that these extracts had strong antiradical scavenging activity [38–42]. It was found that the interesting antioxidant effect is attributed to the presence of flavonoids and other phenolic compounds [42,43].…”

Section: Resultsmentioning

confidence: 55%

GC and GC/MS Analysis of Essential Oil Composition of the Endemic Soqotraen Leucas virgata Balf.f. and Its Antimicrobial and Antioxidant Activities

Mothana

Alsaid

Al-Yahya

et al. 2013

IJMS

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Leucas virgata Balf.f. (Lamiaceae) was collected from the Island Soqotra (Yemen) and its essential oil was obtained by hydrodistillation. The chemical composition of the oil was investigated by GC and GC-MS. Moreover, the essential oil was evaluated for its antimicrobial activity against two Gram-positive bacteria, two Gram-negative bacteria, and one yeast species by using broth micro-dilution assay for minimum inhibitory concentrations (MIC) and antioxidant activity by measuring the scavenging activity of the DPPH radical. The investigation led to the identification of 43 constituents, representing 93.9% of the total oil. The essential oil of L. virgata was characterized by a high content of oxygenated monoterpenes (50.8%). Camphor (20.5%) exo-fenchol (3.4%), fenchon (5.4%), and borneol (3.1%) were identified as the main components. Oxygenated sesquiterpenes were found as the second major group of compounds (21.0%). β-Eudesmol (6.1%) and caryophyllene oxide (5.1%) were the major compounds among oxygenated sesquiterpenes. The results of the antimicrobial assay showed that the oil exhibited a great antibacterial activity against the tested S. aureus, B. subtilis, and E. coli. No activity was found against P. aeruginosa and C. albicans. Moreover, the DPPH-radical scavenging assay exhibited only a moderate antioxidant activity (31%) for the oil at the highest concentration tested (1 mg/mL).

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“…Moreover free radicals by inactivating the enzyme glutamine synthase increase the production of excitatory neurotransmitter glutamic acid, resulting in seizure induction. This is correlated with a decrease in the brain GABA levels by inhibiting the enzyme glutamate decarboxylase by free radicals [2,45,46]. It is safe to conclude that anticonvulsant action of TFGS-ME could be due to its antioxidant effect [23].…”

Section: Discussionmentioning

confidence: 98%

“…It is a chronic progressive disease and affects quality of life [2]. The incidence of epilepsy in industrialized states is about 50 per 100,000 whereas in emerging undeveloped states, it is 100 per 100,000 affecting individuals of all ages, races, and social groups [3].…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant Effects of Trigonella foenum-Graecum L.in Strychnine Induced Epilepsy Model

Khan¹,

Assad²,

Rajput³

2017

jnhfs

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Background: Epilepsy is the 2nd greatest prevalent brain ailment after stroke, and a huge load on health system. Currently available antiepileptic drugs are associated with a lot of adverse effects and exhibit erratic pharmacological effects; hence it is crucial to explore newer anticonvulsant medications having better side effect profile and enhanced pharmacological effects because of the lengthy duration of treatment of epilepsy. Plants are rich source of various bioactive compounds. Numerous plants have been authenticated to be the source of safe and effective medicines and served as substitute to modern medicine. Method: In this study, anticonvulsant action of Trigonella foenumgraecum L. was evaluated in rats by strychnine induced convulsions at three different doses after 14 days of continuous administration. Diazepam at 1mg/kg was consumed as a standard drug. The time to onset of first convulsion, number of convulsions, and duration of convulsions, mortality rate and percent protection was recorded for each animal. Present study was specifically designed to evaluate the anticonvulsant effects of T. foenum-graecum L. Seeds methanol extract. Result: Administration of TFGS-ME for 14 days to rats exhibited significant delay in onset of convulsion at 50 and 100 mg/kg while highly significant delay at 200mg/kg comparable to diazepam. Frequency of convulsion was also decreased significantly at 100 and 200 mg/kg, comparable to diazepam. Duration of convulsion was also decreased significantly at all the three doses given in comparison to control animals. Percent protection in animals received TFGS-ME at 200mg/kg was 90% within 24 h as compared to 10% protection in control animals. Conclusion: Present study gives enough evidences regarding the potential of T. foenum-graecum L. as anticonvulsant agent.

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Free radical scavenging and antiepileptic activity of Leucas lanata

Cited by 21 publications

References 27 publications

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

GC and GC/MS Analysis of Essential Oil Composition of the Endemic Soqotraen Leucas virgata Balf.f. and Its Antimicrobial and Antioxidant Activities

Anticonvulsant Effects of Trigonella foenum-Graecum L.in Strychnine Induced Epilepsy Model

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