Free radical polymerization of poly(ethylene glycol) diacrylate macromers: Impact of macromer hydrophobicity and initiator chemistry on polymerization efficiency

Dai, Xiaoshu; Chen, Xi; Yang, Laura; Foster, Sarah; Coury, Arthur J.; Jozefiak, Thomas H.

doi:10.1016/j.actbio.2011.01.005

Cited by 29 publications

(25 citation statements)

References 40 publications

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“…This latter result may be due to kinetic limitations on the incorporation of NVP within PEGDA networks. 30 …”

Section: Resultsmentioning

confidence: 99%

“…25–29 For instance, N-vinyl pyrrolidone (NVP) has recently been recognized not only as an accelerating agent, 27–28 but also as an SRS that contributes to the physical properties of PEGDA crosslinked systems while maintaining their “blank slate” character. 21, 30 However, only two PEGDA-NVP hydrogel formulations have thus far been identified which allow the examination of distinct moduli (namely 100 kPa and 200 kPa) at consistent average mesh size (or vice versa). 21 Furthermore, Browning et al .…”

Section: Introductionmentioning

confidence: 99%

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Impact of secondary reactive species on the apparent decoupling of poly(ethylene glycol) diacrylate hydrogel average mesh size and modulus

Muñoz-Pinto

Samavedi

Grigoryan

et al. 2015

Polymer

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Poly(ethylene glycol) diacrylate (PEGDA) hydrogels are widely used in biotechnology due to their in situ crosslinking capacity and tunable physical properties. However, as with all single component hydrogels, the modulus of PEGDA networks cannot be tailored independently of mesh size. This interdependence places significant limitations on their use for defined, 3D cell-microenvironment studies and for certain controlled release applications. The incorporation of secondary reactive species (SRS) into PEGDA hydrogels has previously been shown to allow the identification of up to 6 PEGDA hydrogel formulations for which distinct moduli can be obtained at consistent average mesh size (or vice versa). However, the modulus and mesh size ranges which can be probed by these formulations are quite restricted. This work presents an in-depth study of SRS incorporation into PEGDA hydrogels, with the goal of expanding the space for which “decoupled” examination of modulus and mesh size effects is achievable. Towards this end, over 100 PEGDA hydrogels containing either N-vinyl pyrrolidone or star PEG-tetraacrylate as SRS were characterized. To our knowledge, this is the first study to demonstrate that SRS incorporation allows for the identification of a number of modulus ranges that can be probed at consistent average mesh size (or vice versa).

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“…This latter result may be due to kinetic limitations on the incorporation of NVP within PEGDA networks. 30 …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of secondary reactive species on the apparent decoupling of poly(ethylene glycol) diacrylate hydrogel average mesh size and modulus

Muñoz-Pinto

Samavedi

Grigoryan

et al. 2015

Polymer

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“…The infrared spectroscopy showed that the hydroxyl peak [3440 cm −1 ; Figure (A)] disappeared in the PEGDA infrared spectrum [Figure (D)] due to the addition of acrylate groups to the polymer ends, as they observed by Dai et al . The signal of the carbon of the ester bond had a lower intensity in the PEG‐CH semi‐IPN and the PEG‐CH‐K compared with the PEGDA sample [Figure (D–F)] because of the presence of the primary amide band of CH and the carbonyl group of ketoprofen.…”

Section: Resultsmentioning

confidence: 81%

“…Free radical polymerization is a useful method for the formation of crosslinked materials with different applications (i.e., controlled drug release). Here, UV light dissociated the photoinitiator (AIBA) into free radicals that initiate polymerization of PEGDA to form the network (Figure ). A PEG network physically interacting with linear CH chains was obtained.…”

Section: Resultsmentioning

confidence: 99%

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Gaitán-Tolosa

Montiel-Campos

Flores-Estrada

et al. 2018

J of Applied Polymer Sci

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Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti‐inflammatory drug with short half‐life (<2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi‐interpenetrated network of poly(ethylene glycol)‐chitosan. The pore size studied by small‐angle X‐ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 ± 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 ± 0.03 mg/mL, 8 h) and half of the doses up to 24 h. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.

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“…Historically, radical polymerization of hydroxyethyl methacrylate (HEMA) using ethylene dimethacrylate (EDMA) as a crosslinker was extensively studied for commercial-scale manufacturing of flexible contact lenses. 181 A large number of macromolecules, such as HA, 67, 202–204 chitosan, 193, 205 and PEG, 205, 206 are easily functionalized with vinyl end groups and can undergo radical polymerization to form hydrogels in presence of appropriate initiators. For example, Morelli and Chiellini functionalized Ulvan, a sulfated polysaccharide from green seaweed, with methacryloyl groups.…”

Section: Materials Functionalization For Hydrogel Formationmentioning

confidence: 99%

Designing degradable hydrogels for orthogonal control of cell microenvironments

2013

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Free radical polymerization of poly(ethylene glycol) diacrylate macromers: Impact of macromer hydrophobicity and initiator chemistry on polymerization efficiency

Cited by 29 publications

References 40 publications

Impact of secondary reactive species on the apparent decoupling of poly(ethylene glycol) diacrylate hydrogel average mesh size and modulus

Impact of secondary reactive species on the apparent decoupling of poly(ethylene glycol) diacrylate hydrogel average mesh size and modulus

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Designing degradable hydrogels for orthogonal control of cell microenvironments

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