Free radical formation by Lactobacillus acidophilus NCFM is enhanced by antioxidants and decreased by catalase

Hougaard, Anni Bygvrå; Pindstrup, Helene; Arneborg, Nils; Andersen, Mogens L.; Skibsted, Leif H.

doi:10.1016/j.foodres.2015.12.003

Cited by 15 publications

(5 citation statements)

References 43 publications

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“…It has been reported that free radicals cause oxidative damage to biomolecules and have significant effects on cardiovascular diseases, aging, cancer, and inflammatory diseases (Jimenez et al, 2011, Katsampa et al, 2015). Antioxidants have good prophylactic and therapeutic potential for free radical-related disease disorders (Cao et al, 2015, Hougaard et al, 2016). Many studies have shown that polyphenols have strong antioxidant properties in vitro (Gangopadhyay et al, 2016, Jurinjak Tušek et al, 2016, Zielinska and Michalska, 2016).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and xanthine oxidase inhibitory activities of total polyphenols from onion

Ouyang

Hou

Peng

et al. 2018

Saudi Journal of Biological Sciences

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Onions (Allium cepa L.) comprise a valuable vegetable crop in many countries. Modern scientific research has shown that onions possess many biological activities, including antibacterial, anticancer, hypoglycemic, hypolipidemic, antiplatelet aggregation, and antioxidant activities. The goal of this study was to investigate the impact of total onion polyphenols on antioxidant and xanthine oxidase (XO) inhibitory activities. Total onion polyphenols showed significant antioxidant activity in DPPH, FRAP, and OH-assays (IC50 [µg/mL]), 43.24, 560.61, and 12.97, respectively). In a X/XO system, antioxidant properties of these polyphenols significantly inhibited XO activity (IC50 [µg/mL], 17.36). These results indicated that total onion polyphenols showed promising antioxidant and anti-gout properties and might be used as potential, natural drugs against oxidative diseases after successful studies in vivo as well as clinical trials.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and xanthine oxidase inhibitory activities of total polyphenols from onion

Ouyang

Hou

Peng

et al. 2018

Saudi Journal of Biological Sciences

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“…Previous studies showed that divalent metal ions significantly influenced the growth of L. lactis (Li and Ma, 2014). Metals taken up by the bacteria during incubation would lead to a reduction in radical formation (Hougaard et al, 2016) and change of the secondary structures of the S-layers (Gerbino et al, 2011). In addition, divalent metal ions are a common motive found in all enzymatic classes (Ewert et al, 2018); Ca 2+ ions play an important role on the fructosyltransferase and β-galactosidase of Lactobacillus (Ozimek et al, 2005;Ji et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Combined proteomics and transcriptomics analysis of Lactococcus lactis under different culture conditions

Yang

Hong

et al. 2021

Journal of Dairy Science

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During industrial handling, Lactococcus lactis needs to adapt to different culture conditions by regulating its metabolic pathways. Modifying culture conditions may be an important way to control the biomass and functional metabolites of lactic acid bacteria. In this study, we identified the differentially expressed genes and proteins of L. lactis under different culture conditions by integrating transcriptomics and proteomics. We also analyzed the data using a bioinformatic approach to reveal the regulatory mechanisms affected by culture conditions. The transcriptome and proteome studies indicated that different culture conditions (fructose, calcium ion, palmitic acid, low pH) affected gene and protein expressions. The levels of differentially expressed proteins did not significantly correlate with the expression levels of their corresponding genes. Our results highlight the importance of comparative transcriptomics and proteomics analyses. In this study, fructose and pH significantly affected sugar metabolism of L. lactis. When lactose was replaced by fructose, fructokinase expression was promoted, and fructose metabolism was accelerated, whereas starch and sucrose metabolism and galactose metabolism system were inhibited. Low pH may be beneficial to homofermentation of L. lactis, which may also metabolize galactose through the tagatose pathway and the Leloir pathway. Fatty acid metabolism and fatty acid biosynthesis were significantly downregulated under calcium ion and palmitic acid. The purine metabolism was upregulated under fructose treatment and downregulated under palmitic acid treatment.

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“…Antioxidant enzymes associated with diseases of the blood circulation system and tissues have been developed. Obesity could affect the oxidative stress level through Other studies showed that T-AOC, liver GPT and GOT levels and enzymatic antioxidant activities of SOD, CAT and GSH-Px could also be used as indexes of oxidative damage 31,48 . The increase of antioxidant enzymes activity in liver is partly due to its high content in Lactobacillus.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies showed that T-AOC, liver GPT and GOT levels and the enzymatic antioxidant activities of SOD, CAT and GSH-Px could also be used as indexes of oxidative damage. 32,49 The increase of antioxidant enzyme activity in the liver is partly due to its high content of Lactobacillus. When the LAB cell is broken, intracellular enzymes will be obtained and contributed to the antioxidant system.…”

Section: Discussionmentioning

confidence: 99%

The antioxidative effects of three lactobacilli on high-fat diet induced obese mice

Song

Shan

et al. 2016

RSC Adv.

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In this paper, three Lactobacillus strains (L. coryniformis subsp. torquens T3, L. paracasei subsp. paracasei M5 and L. paracaseisubp. paracasei X12) isolated by our laboratory were investigated for antioxidant activity in vitro and in vivo. Hydroxyl and 2,2-diphenyl-1picrylhydrazyl (DPPH) free radicals scavenging activities, and reducing power were examined in vitro. Three Lactobacillus strains were administered to high-fat diet induced obesity mice.The results indicated that T3 and M5 showed the highest hydroxyl radical and DPPH scavenging activities at a dose of 10 9 CFU/mL, with inhibition rates of 40.33, 41.11% and 40.76, 44.31%, respectively. The reducing activities of these two strains were also significantly higher than X12. Comparing with high-fat diet group, M5 and T3 have effectively controlled the body weight and hepatomegaly and significantly decreased the blood triglyceride and total cholesterol levels (p<0.05). Besides, M5 and T3 obvious improved antioxidative indexes including MDA levels, T-SOD, GSH-Px, CAT and T-AOC activities. Overall, M5 and T3 has a strong antioxidant activity in vitro and can improve oxidative damage and control body weight in mice, suggesting that it may be a potential anti-obesity and antioxidant probiotic.

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Free radical formation by Lactobacillus acidophilus NCFM is enhanced by antioxidants and decreased by catalase

Cited by 15 publications

References 43 publications

Antioxidant and xanthine oxidase inhibitory activities of total polyphenols from onion

Antioxidant and xanthine oxidase inhibitory activities of total polyphenols from onion

Combined proteomics and transcriptomics analysis of Lactococcus lactis under different culture conditions

The antioxidative effects of three lactobacilli on high-fat diet induced obese mice

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