Free radical copolymerization of 2-hydroxyethyl methacrylate with butyl methacrylate: determination of monomer reactivity ratios and glass transition temperatures

Fernández‐García, Marta; Torrado, M.F; Martínez, Gerardo; Sánchez‐Chaves, Manuel; Madruga, Enrique López

doi:10.1016/s0032-3861(00)00167-1

Cited by 63 publications

(41 citation statements)

References 31 publications

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“…The pore size of the investigated samples decreases in the following order: Thermal Behavior of P(HEMA/IA/PAGM). Several T g values for PHEMA have been reported in the literature, with T g s ranging from 85 to 105 o C. [43][44][45] In our study, we examined the effects of composition on the thermal behavior of P(HEMA/ IA/PAGM) copolymers. For all P(HEMA/IA/PAGM) networks and the PHEMA homopolymer, a single T g value was observed, and there was a visible dependence of the T g value on the copolymer composition ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

et al. 2014

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Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/ IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.

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Section: Resultsmentioning

confidence: 99%

pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

et al. 2014

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“…Their values are lower than those found in the literature for homopolymers synthesized by conventional free radical polymerization. 31 This is expected, because the glass transition temperature decreases as does the molecular weight.…”

Section: Analysis Of the Glass Transition Temperaturementioning

confidence: 89%

Synthesis and characterization of PMMA‐b‐PBMA block copolymers by atom transfer radical polymerization

Fuente

Fernández-Sanz

Madruga

2002

J of Applied Polymer Sci

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ABSTRACT:The synthesis of diblock copolymers using atom transfer radical polymerization, ATRP, of n-butyl methacrylate, BMA, and methyl methacrylate, MMA, is reported. These copolymers were prepared from 2-bromoisobutyryl-terminated macroinitiators of poly(MMA) and poly(BMA), using copper chloride, CuCl,/N,N,NЈ,NЉ,NЉ-pentamethyldiethylenetretramine, PMDETA, as the catalyst system, at 100°C in bulk and in benzonitrile solution. The block copolymers were characterized by means of size-exclusion chromatography, SEC, and 1 H-NMR spectroscopy. The SEC analysis of the synthesized diblock copolymers confirmed important differences in the molecular weight control depending on the reaction medium (solvent effect) and the chemical structure of the macroinitiator used. In addition, differential scanning calorimetry, (DSC) measurements were performed, showing for all the copolymers a phase separation.

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“…10. In order to overcome the difficulty of copolymerization between the VAc monomer and St monomer [37][38][39][40][41] and solve the stable problem of PVAc/PS emulsion [31][32][33], the intermediate coupling monomer, MA, was introduced into the reactive system. The mode of the MA monomer grafting on the surface of the PVAc core or reacting with St monomer was random [42,43].…”

Section: Mechanism Of Ics Synthesis and Morphological Evolutionmentioning

confidence: 99%

Fabrication and morphological evolution of inverse core/shell structural latex particles of poly(vinyl acetate)/polystyrene by maleic anhydride grafting

et al. 2016

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In order to overcome the large differences in reactivity ratio and hydrophilicity between vinyl acetate (VAc) monomer and styrene (St) monomer and synthesize a stable poly(vinyl acetate)/polystyrene (PVAc/PS) inverse core/shell (ICS) structural emulsion, this paper presented a novel method to prepare PVAc/PS ICS structural latex particles. Maleic anhydride (MA) grafting, for the first time, was introduced to fabricate the ICS latex particles, where VAc monomer was used as the core monomer and St monomer as the shell monomer. By adjusting the core/shell (CS) ratio and MA content, the morphology of the particles could be controlled to have a regular evolution from strawberry-like to semi-wrapped and final ball-like. In addition, upon MA content exceeding 1 % (percentage of the total monomer), the secondary nucleation almost disappeared gradually. The resulting ICS particles had an average diameter approximately 330 nm and a controllable distribution. Further results of characterization such as phase separation structure, existence of thin transition layer, and special morphological feature of latex particle also demonstrated that this ICS structure had been fabricated successfully. The mechanism of formation was displayed as well.

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Free radical copolymerization of 2-hydroxyethyl methacrylate with butyl methacrylate: determination of monomer reactivity ratios and glass transition temperatures

Cited by 63 publications

References 31 publications

pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

Synthesis and characterization of PMMA‐b‐PBMA block copolymers by atom transfer radical polymerization

Fabrication and morphological evolution of inverse core/shell structural latex particles of poly(vinyl acetate)/polystyrene by maleic anhydride grafting

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