Free osseous and soft tissue surgical margins as prognostic factors in mandibular osteosarcoma

Granados-García, Martín; Ortíz, Kuauhyama Luna; Castillo-Oliva, Herbert A.; Villavicencio-Valencia, Verónica; Herrera‐Gómez, Ángel; Mosqueda‐Taylor, Adalberto; Aguilar-Ponce, José Luis; Poitevin-Chacón, Adela

doi:10.1016/j.oraloncology.2005.06.027

Cited by 34 publications

(18 citation statements)

References 26 publications

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“…14 Complete surgical resection has been found to be the most important prognostic factor. 28 The median progression-free survival time in our series was 7.5 months in patients who underwent subtotal resection and 21 months in those who underwent gross-total resection (P ¼ .2319). When comparing the skull base radiation-induced osteosarcoma group with the calvarial radiation-induced osteosarcoma group, the median progression-free survival intervals were 9.5 months and 19 months, respectively (P ¼ .6322).…”

Section: Discussionmentioning

confidence: 58%

Radiation‐induced osteosarcomas of the calvarium and skull base

Patel

Rao

Fox

et al. 2010

Cancer

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BACKGROUND: Although a rare complication of ionizing radiation, radiation-induced osteosarcoma is now more frequently recognized as radiation therapy has become common and cancer survival has increased. To date, publications on radiation-induced osteosarcoma of the cranium are limited to a few small series and case reports. METHODS: Data from 175 patients with a history of sarcoma of the head at The University of Texas M. D. Anderson Cancer Center from 1975 to 2007 were reviewed to identify patients with radiation-induced osteosarcoma. The diagnostic criteria were: 1) osteosarcoma arose within the previously irradiated field; 2) new sarcoma was histologically distinct from the original neoplasm; 3) no evidence of new sarcoma at the time of radiation; and 4) distinct latency period could be recognized. Frequencies and descriptive statistics were obtained for the various characteristics under study. RESULTS: The authors identified 16 patients with radiation-induced osteosarcoma of the cranium at their institution. The average age at diagnosis was 35 years. The median latency period was 12.5 years. Nine patients had skull base tumors, and 7 had calvarial tumors. Of the 14 patients treated surgically, 86% developed local recurrence. The median survival time was 29 months, and the 5-year survival rate was 29.6%. CONCLUSIONS: The authors report the largest series of cranial radiation-induced osteosarcoma. Although radiation-induced osteosarcoma is an uncommon but dire complication of radiotherapy, its incidence will probably increase in the future as the frequency of radiation treatment and cancer survival increase. These tumors are locally aggressive, and despite aggressive surgical and medical management, they have a high rate of local recurrence and mortality. Cancer 2011;117:2120-6.

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Section: Discussionmentioning

confidence: 58%

Radiation‐induced osteosarcomas of the calvarium and skull base

Patel

Rao

Fox

et al. 2010

Cancer

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“…Therapeutic options for craniofacial osteosarcoma are surgery, radio-and chemotherapy which are employed according to age of the patient, histological classification and localization of the tumour. For surgery, a wide resection e if necessary with follow-up resection (Granados-Garcia et al, 2006) e has been recommended (Yamaguchi et al, 2004). From some authors, it has been suggested that operation alone is sufficient initial therapy when a complete resection can be conducted.…”

Section: Discussionmentioning

confidence: 99%

Clinical, therapeutic and prognostic features of osteosarcoma of the jaws – Experience of 36 cases

Kämmerer

Shabazfar

Makoie

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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“…Nevertheless, despite the best staging and the most delicate and careful reconstruction techniques, it comes naturally that the 3 cm resection margin usually advocated for sarcomas of other sites (e.g., long bones sarcomas) is unthinkable when dealing with the head and neck structures. If we take into account literature reports, safety margins for head and neck osteosarcoma vary, from the observation of Granados-Garcia, who suggests a resection tailored on tumor size in the head and neck region [64], to the 1 cm minimal resection margin suggested by Ketabchi [65] [ Figure 5]. …”

Section: Surgerymentioning

confidence: 99%

“…Diferent laps have already been proposed including the iliac crest microvascular free laps [64], radial forearm lap with partial radius inclusion [67] and scapula osteocutaneous lap [68].…”

Section: Osteosarcoma -Biology Behavior and Mechanisms 208mentioning

confidence: 99%

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Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

Ferrari¹,

Moneghini²,

Allevi³

et al. 2017

Osteosarcoma - Biology, Behavior and Mechanisms

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Osteosarcomas are rare, highly malignant, bone tumors deined by the presence of malignant mesenchymal cells producing osteoid or immature bone. Osteosarcomas of the jaws are extremely rare, representing about 7% of all osteosarcomas and 1% of all head and neck malignancies. An accurate diagnosis, usually facilitated by chemotherapy (CT), MRI and biopsy, is required in order to deine the stage of the disease and plane the adequate treatment. Aggressive surgical resection and advanced technique reconstruction are the mainstay of treatment, as the single most important factor for cure is radical resection. Clinical outcomes can be improved by a multimodal strategy combining surgery with neo-adjuvant and adjuvant chemotherapy in selected cases, and adjuvant radiotherapy in the absence of clear margins.

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Free osseous and soft tissue surgical margins as prognostic factors in mandibular osteosarcoma

Cited by 34 publications

References 26 publications

Radiation‐induced osteosarcomas of the calvarium and skull base

Radiation‐induced osteosarcomas of the calvarium and skull base

Clinical, therapeutic and prognostic features of osteosarcoma of the jaws – Experience of 36 cases

Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

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