Clinical, therapeutic and prognostic features of osteosarcoma of the jaws – Experience of 36 cases

Kämmerer, Peer W.; Shabazfar, Niloufar; Makoie, Nadja Vorkhshori; Moergel, Maximilian; Al‐Nawas, Bilal

doi:10.1016/j.jcms.2011.10.001

Cited by 37 publications

(44 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ewing's sarcoma has a relatively simple genetic signature, consisting of a t(11;22) translocation (7,8). However, certain other sarcomas, including osteosarcoma, chondrosarcoma and undifferentiated sarcoma, are characterized by more complex genetic abnormalities (9).…”

Section: Introductionmentioning

confidence: 99%

The importance of Src signaling in sarcoma

et al. 2015

View full text Add to dashboard Cite

Abstract. Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previous studies have suggested that Src has essential functions in cell proliferation, apoptosis, invasion, metastasis and the tumor microenvironment. Thus, it may be a potential target for cancer therapy. Src has been found to enhance proliferation, reduce apoptosis and promote metastasis in certain subtypes of sarcoma, including osteosarcoma, chondrosarcoma and Ewing's sarcoma. Furthermore, a number of novel effective therapeutic agents, such as SI-83, which target Src have been investigated in vitro and in vivo. Bosutinib and dasatinib, which inhibit Src, have been approved by the U.S. Food and Drug Administration for the treatment of chronic myelogenous leukemia. In addition, vandetanib is approved for the treatment of medullary thyroid cancer. Furthermore, the Src inhibitor, saracatinib, is currently in clinical trials for the treatment of a variety of solid tumors, including breast and lung cancers. Thus, Src is considered to be an important factor in sarcoma progression and may present a novel clinical therapeutic target. This review demonstrates the importance and clinical relevance of Src in sarcoma, and discusses a number of small molecular inhibitors of src kinase, such as dasatinib and sarcatinib, which are currently in clinical trials for the treatment of sarcoma patients.

show abstract

Section: Introductionmentioning

confidence: 99%

The importance of Src signaling in sarcoma

et al. 2015

View full text Add to dashboard Cite

show abstract

“…12,17 In addition, the role of radiation therapy for the treatment of JOS is unclear because some studies have reported significant improvement in survival with radiation therapy in patients with positive or uncertain margins, while others report no significant improvement for patients with positive or negative margins. 1,3,11,15,[19][20][21][22][23][24] A large population-based study of JOS could help clarify the roles of multimodal therapy in JOS treatment. While there are several single and multicenter studies reported, population data are scarce and controversial.…”

mentioning

confidence: 99%

Characteristics and Prognostic Factors of Osteosarcoma of the Jaws

Lee

Arshi

Schwartz

et al. 2015

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…From the results of previous studies, it cannot be confirmed whether chemotherapy has an effect on the prognosis of patients with osteosarcoma (26,27); this may be due to the diversity in chemotherapy regimens that were administered. A number of previous studies reported that modern adjuvant chemotherapy increased the survival time of patients, and in certain cases, also controlled metastasis (10).…”

Section: Discussionmentioning

confidence: 99%

“…Osteosarcoma of the jaw is rare, accounting for ~1% of all head and neck malignancies (9). The disease has a moderate male predilection, with a peak in incidence in the second to third decades of life (10). The maxilla and the mandible are affected almost equally, with the alveolar ridge and the antrum in the maxilla and the body of the mandible serving as preferential sites for the tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Certain well-differentiated tumors grow slowly and present as benign lesions. As a malignant tumor, osteosarcoma is invasive, and may cause irreversible numbness if the neoplasm invades the inferior alveolar nerve (10). This form of numbness is dissimilar to the paresthesia experienced by patients with cementoblastoma, which is caused by tumor pressure.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Misdiagnosis of osteosarcoma as cementoblastoma from an atypical mandibular swelling: A case report

Fang¹,

Jin²,

Zhang³

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Cementoblastoma is a form of benign odontogenic tumor, with the preferred treatment consisting of tooth extraction and follow-up examinations, while in certain cases, follow-up examinations without surgery are performed. Osteosarcoma of the jaw is a rare, malignant, mesenchymal tumor, associated with a high mortality rate and low incidence of metastasis. Cementoblastoma and osteosarcoma of the jaw are dissimilar in terms of their histological type and prognosis; however, there are a number of covert associations between them. The present study describes the case of a 20-year-old female with an unusual swelling in the left mandible that had been present for 2 years. The patient was initially clinically diagnosed with cementoblastoma; however, following pathological examination, a diagnosis of osteosarcoma was confirmed. A total mandibulectomy was performed on the left mandible, with a fibular osteomyocutaneous flap used for reconstruction. At the 6-month post-operative examination, the patient demonstrated normal occlusion and oral commissure, and no recurrence or metastasis was observed over 2 years of follow-up.

show abstract

Clinical, therapeutic and prognostic features of osteosarcoma of the jaws – Experience of 36 cases

Cited by 37 publications

References 63 publications

The importance of Src signaling in sarcoma

The importance of Src signaling in sarcoma

Characteristics and Prognostic Factors of Osteosarcoma of the Jaws

Misdiagnosis of osteosarcoma as cementoblastoma from an atypical mandibular swelling: A case report

Contact Info

Product

Resources

About