Free muscle graft pharyngoplasty with palatal retroposition in the treatment of velopharyngeal incompetence

Thompson, Noel

doi:10.1007/bf00289050

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Thompson [8,9] verbes serte die Methode durch die Kombination der klassischen Wardill-Kilner-Operation in der freien Muskeltransplanta Eingcgangen: 5. Februar LW2 Angenommen: 7.…”

Section: Introductionunclassified

Die gestielte Transposition des Musculus digastricus und stylohyoideus zur Behandlung der Velopharynxinkompetenz

Kärcher

Radner²,

Anderhuber³

1992

Cells Tissues Organs

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The anatomical basis for the application of neurovascular pedicled muscle transfers of the digastric and stylohyoid muscles in the treatment of velopharynx incompetence is described. The fact that the neurovascular pedicle is located in the cranial third of the muscle bellies provides the safety of the operative procedure. The muscles have to be dissected with respect to that. The direction in which the transferred muscles pull is described. The muscle transposition is combined with the classic Wardill-Kilner operation to lengthen the soft palate. The transferred muscles have to avoid scar contraction and shortening of the soft palate and to gain a muscular function of the soft palate. The clinical use is justified in rare cases as demonstrated in one case.

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“…Thompson [8,9] verbes serte die Methode durch die Kombination der klassischen Wardill-Kilner-Operation in der freien Muskeltransplanta Eingcgangen: 5. Februar LW2 Angenommen: 7.…”

Section: Introductionunclassified

Die gestielte Transposition des Musculus digastricus und stylohyoideus zur Behandlung der Velopharynxinkompetenz

Kärcher

Radner²,

Anderhuber³

1992

Cells Tissues Organs

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“…Finally, appropriate sensory neuron-muscle interactions are critical to complete functional differentiation of regenerating muscles. Particularly when clinical applications of muscle grafting are considered (Hakelius, 1977(Hakelius, ,1979Thompson, 1979), it is important to evaluate the variables that may be involved in return of the sensory feedback normally provided by muscle spindles.…”

Section: Introductionmentioning

confidence: 99%

Muscle spindle formation and differentiation in regenerating rat muscle grafts

Rogers

1982

Developmental Biology

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Muscle spindle development and function are dependent upon sensory innervation. During muscle regeneration, both neural and muscul.ar components of spindles degenerate and it is not known whether reinnervation of a regenerating muscle results in Ireestablishment of proper neuromuscular relationships within spindles or whether sensory neurons may exert an influence upon differentiation of these spindles. Muscle spindle regeneration was studied in bupivacainetreated grafts of rat extensor digitorum longus (EDL) muscles. Three types of EDL graft were performed in order to manipulate the extent to which regenerating spindles might be reinnervated: (1) grafts reinnervated following severance of their nerve supply (standard grafts); (2) grafts in which intact nerve sheaths appear to facilitate reinnervation (nerveintact grafts); and (3) grafts in which reinnervation was prevented (nonreinnervated grafts). Complete degeneration of muscle fibers occurred in all grafts prior to regeneration. Initial formation of spindles in regenerating EDL grafts is independent of innervation; intrafusal muscle fibers degenerate and regenerate within spindle capsules that remain intact and viable. The extent of spindle differentiation was evaluated in each type of graft using criteria that included nucleation and ATPase activity, both of which have been shown to be regulated by sensory innervation, as well as the number of muscle fibers/spindle and morphology of spindle capsules. While most spindles contained normal numbers of muscle fibers, most of these fibers were morphologically and histochemically abnormal. Alterations of ATPase activity occurred in all spindles, but were least severe in nerve-intact grafts. While fully differentiated nuclear bag and chain fibers were not observed in regenerated spindles, large, vesicular nuclei, similar to those of normal intrafusal fibers, were present in a small number of spindles in nerve-intact grafts. Sensory nerve terminations were observed only in those spindles that also contained the distinctive nuclei. This study suggests that a specific neurotrophic influence is necessary for regeneration of normal intrafusal muscle fibers and that this influence corresponds to the properly timed sensory neuron-muscle interaction which directs muscle spindle embryogenesis. However, the infrequent occurrence of characteristics unique to intrafusal muscle fibers indicates that reinnervation of regenerating muscle grafts by sensory neurons is inadequate and/or faulty.

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Restoration of Emotional Expression to the Unilaterally Paralysed Face

Thompson

Parry

1981

Muscle Transplantation

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Free muscle graft pharyngoplasty with palatal retroposition in the treatment of velopharyngeal incompetence

Cited by 5 publications

References 34 publications

Die gestielte Transposition des Musculus digastricus und stylohyoideus zur Behandlung der Velopharynxinkompetenz

Die gestielte Transposition des Musculus digastricus und stylohyoideus zur Behandlung der Velopharynxinkompetenz

Muscle spindle formation and differentiation in regenerating rat muscle grafts

Restoration of Emotional Expression to the Unilaterally Paralysed Face

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