Free lung cell response after combined exposure to cigarette smoke and industrial dusts

Rylander, Ragnar; Sjöstrand, Margareta; Bergström, R

doi:10.1016/0300-483x(79)90067-2

Cited by 13 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rylander and colleagues (82) have used the cellular content of washings of excised lungs to determine the heightened pulmonary response of guinea pigs to aerosols of airborne dusts and cigarette smoke in sequential combinations over the response seen in exposures to either aerosol alone. Henderson et al (83) were able to detect differences in the response of rats to either fly ash or H2SO4 aerosols alone and to a combined exposure to the two materials by analysis of lung washings for LDH and glutathione reductase activities.…”

Section: Methods Of Lavagementioning

confidence: 99%

Use of bronchoalveolar lavage to detect lung damage.

Henderson¹

1984

Environ Health Perspect

145

View full text Add to dashboard Cite

The assay of bronchoalveolar washings from acutely exposed animals has proven useful as a rapid screen for lung injury from inhaled airborne toxins. The screen is useful for choosing appropriate compounds and exposure levels for subsequent in-depth studies in which complete histopathologic evaluations will be made. An inflammatory response can be detected by the appearance of polymorphonuclear leukocytes and an increase in protein content of lung washings. The release of the cytoplasmic enzyme, lactate dehydrogenase, into the acellular portion of the lavage fluid serves as an indication of cell death or membrane damage. A large increase in some lysosomal enzymes has been found in the bronchoalveolar lavage fluids from animals chronically exposed to insoluble particles. Angiotensin-converting enzyme has been found to be elevated in bronchoalveolar washings from animals with endothelial cell damage in the pulmonary capillaries. The correlation of these cellular and biochemical alterations in the bronchoalveolar lavage fluid with morphological indications of damage has served to validate this method of detecting acute lung injury. Further study is needed to validate indicators of developing chronic disease. Images FIGURE 1. FIGURE 4. C1 FIGURE 4. C2 FIGURE 4. C3 FIGURE 6. FIGURE 6. FIGURE 6. FIGURE 6.

show abstract

Section: Methods Of Lavagementioning

confidence: 99%

Use of bronchoalveolar lavage to detect lung damage.

Henderson¹

1984

Environ Health Perspect

145

View full text Add to dashboard Cite

show abstract

“…Als besonderer Unterschied zum Quarzstaub fiel ein wesentlich geringerer Lymphotropismus auf [25,26]. Titandioxid wurde in eine große Anzahl experimenteller Untersuchungen als Beispiel eines reaktionsarm vertragenen (�inerten�) Staubes einbezogen [27][28][29][30][31][32][33][34]. Die geringe Reaktion auf Titandioxidstaub wurde kürzlich nochmals im Tierexperiment an der Ratte bei intrapleuraler und intraperitonealer Applikation durch Grasso und Mitarbeiter [35] bestätigt.…”

Section: Tierexperimentelle Untersuchungenunclassified

Titandioxid [MAK Value Documentation in German language, 1986]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 11. Lieferung, Ausgabe 1986 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter und Eigenschaften Erfahrungen beim Menschen Tierexperimentelle Untersuchungen Zur Möglichkeit krebserzeugender Wirkungen Zytotoxizität Begründung des MAK‐Wertes

show abstract

Titanium Dioxide

Battersby,

Warheit

2023

Patty's Toxicology

View full text Add to dashboard Cite

Titanium is a naturally occurring element. The commercially most important titanium compound is pigmentary TiO 2 , whereas nano‐scaled TiO 2 represents only a small amount on the market. Since humans are exposed to TiO 2 at workplace or through consumer products, a thorough evaluation of its potential toxicity has been summarized herein. Dermal absorption of TiO 2 is deemed to be negligible, whereas oral and inhalation absorption has been reported but is assumed to be very low. TiO 2 has been shown to be of low acute oral, dermal, and inhalation toxicity and is considered to be void of skin and eye‐irritating properties. It also does not show any potential for skin and respiratory sensitization. Oral long‐term toxicity studies in rats report no adverse effects, and due to lack of dermal absorption of TiO 2 , it is assumed that dermal exposure is also not a hazard. TiO 2 does not show any primary mutagenicity and is also void of reproductive or developmental toxicity. However, in long‐term inhalation toxicity studies in rats, inflammation, fibroproliferative effects, and lung tumor formation has been observed but only under conditions of excessive particle lung overload. Carcinogenicity under such extreme conditions with complete cessation of lung clearance is considered to not imply a cancer hazard for humans, which is in line with epidemiological studies showing no causative link between TiO 2 particle exposure and cancer risk in humans. However, based on the available animal database, IARC in the past classified TiO 2 as possibly carcinogenic to humans, and the Risk Assessment Committee of ECHA also concluded that TiO 2 warrants a Category 2 classification for carcinogenicity.

show abstract

Free lung cell response after combined exposure to cigarette smoke and industrial dusts

Cited by 13 publications

References 8 publications

Use of bronchoalveolar lavage to detect lung damage.

Use of bronchoalveolar lavage to detect lung damage.

Titandioxid [MAK Value Documentation in German language, 1986]

Titanium Dioxide

Contact Info

Product

Resources

About