Free fatty acids in the cuticular and internal lipids of Calliphora vomitoria and their antimicrobial activity

Gołębiowski, Marek; Cerkowniak, Magdalena; Boguś, Mieczysława I.; Włóka, Emilia; Dawgul, Małgorzata; Kamysz, Wojciech; Stepnowski, Piotr

doi:10.1016/j.jinsphys.2013.02.001

Cited by 48 publications

(50 citation statements)

References 42 publications

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“…In addition, they also affect the absorption of chemicals from the environment, can serve as pheromones, and most important for honeybee health, form a most efficient obstacle against the attachment to or penetration of the insect cuticle by microorganisms (Blomquist and Jackson 1979;Lockey 1988). They form an oily layer on the cuticle, which is continuously renewed by glandular secretions and prevents fungi and bacteria from entering the bees' body (Blomquist et al 1980;Koidsumi 1957;Gołębiowski et al 2013). The cuticular hydrocarbon composition varies during individual development and is dependent on both the environment and the individual health status (Blomquist et al 1980).…”

Section: Cuticular Hydrocarbonsmentioning

confidence: 99%

“…Beeswax is secreted by the wax glands and is composed of a complex mix of alkanes, alkenes, hydrocarbons (14 %), free fatty acids (12 %), monoesters (35 %), diesters (14 %), hydroxymonoesters and some minor constituents (fatty alcohols and hydroxydiesters) (Hepburn et al 2014;Mizrahi and Lensky 1997). The beeswax antibiotic activity is known for the fatty acids rather than the esters (Koidsumi 1957;Gołębiowski et al 2013). Only very few studies address the biological activity of beeswax extracts against bee parasites and pathogens, but the natural comb has never been tested in situ in a biological setting.…”

Section: Beeswaxmentioning

confidence: 99%

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Pharmacophagy and pharmacophory: mechanisms of self-medication and disease prevention in the honeybee colony (Apis mellifera)

2015

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-Apitherapy promises cures for diseases in human folk medicine, but the effects of honeybee produced and foraged compounds on bee health are less known. Yet, hive products should chiefly facilitate medication and sanitation of the honeybees themselves rather than other organisms. We here review the impact of both self-produced gland secretions and foraged hive products (pharmacognosy) on colony health. Although foraged plant-derived compounds vary highly in antibiotic activity depending on the floral and regional origins, secondary plant metabolites in honey, pollen and propolis are important for the antibiotic activity against pathogens and parasites. However, specific bee health-enhancing activities of bee products should clearly be distinguished from the effects of an intact nutrition ensuring the basic immune competence of bees. Further unravelling the interactions among groups of active substances or individual compounds used in concert with specific behavioural adaptations will deepen our understanding of the natural potential of honeybees to maintain colony health.honey / propolis / pollen / bee bread / royal jelly / antimicrobial activity / self-medication / host-parasite interaction

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Section: Cuticular Hydrocarbonsmentioning

confidence: 99%

Section: Beeswaxmentioning

confidence: 99%

Pharmacophagy and pharmacophory: mechanisms of self-medication and disease prevention in the honeybee colony (Apis mellifera)

2015

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“…; Urbanek et al . ; Gołębiowski et al ., ). Chemical components occurring in epicuticular layers are obtained from diet or derived from fat bodies, where they are metabolized and stored in adipocytes (Wigglesworth ; Arrese and Soulages ).…”

Section: Introductionmentioning

confidence: 97%

“…The most abundant fatty acids were 18:1 16:0 16:1 18:0 18:2 (Gołębiowski et al . ,c), typical for dipteran species (Downer ). Similar results were obtained for cuticular lipids found in larvae and pupae of Calliphora vicina (Gołębiowski et al .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species

et al. 2013

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Aims: This article describes the qualitative and quantitative analyses of untypical compounds in the cuticular and internal lipids of four dipteran species. For isolated compounds, antimicrobial activity against 18 reference strains of bacteria and fungi was determined. Methods and Results: In this study, gas chromatography (GC) combined with mass spectrometry (GC-MS) was used to analyse the surface and internal compounds of four fly species. Seven untypical compounds from both preimaginal and imaginal stages of examined insects were identified. Azelaic acid (AA) was the most abundant, while phenylacetic and phenylpropionic acids occurred in lower concentration. Minor quantities of sebacic acid, 2-methyl-2-hydroxybutanoic acid, tocopherol acetate and trace amounts of 2,4-decadienal were also detected. Tocopherol acetate was found only in cuticular lipids of Musca domestica larvae. Each compound was tested against several species of fungi and bacteria by determining minimal inhibitory concentration (MIC). Human pathogenic fungi were also investigated. Phenylpropionic acid showed the greatest antifungal activity. Bacterial strains were insensitive to the presence of identified compounds, apart from 2,4-decadienal which strongly inhibited bacterial growth. Conclusions: This is the first time that the chemical composition and the antimicrobial activity of untypical compounds in the cuticular and internal lipids of four fly species has been analysed. Significance and Impact of the Study: Determination of untypical compounds and their antimicrobial activity can effectively contribute to the knowledge concerning insect defence mechanisms.

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“…Lipids are generally distributed on the surface of eggs and the ovipositor of insects as cuticular lipids. [15][16][17] This information may help us to confirm the structure of the elicitor.…”

Section: )mentioning

confidence: 98%

Elicitor(s) inSogatellafurcifera(Horváth) Causing the Japanese Rice Plant (Oryza sativaL.) to Induce the Ovicidal Substance, Benzyl Benzoate

Yang

Nakayama

Toda

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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Free fatty acids in the cuticular and internal lipids of Calliphora vomitoria and their antimicrobial activity

Cited by 48 publications

References 42 publications

Pharmacophagy and pharmacophory: mechanisms of self-medication and disease prevention in the honeybee colony (Apis mellifera)

Pharmacophagy and pharmacophory: mechanisms of self-medication and disease prevention in the honeybee colony (Apis mellifera)

Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species

Elicitor(s) inSogatellafurcifera(Horváth) Causing the Japanese Rice Plant (Oryza sativaL.) to Induce the Ovicidal Substance, Benzyl Benzoate

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