Free‐breathing multislice native myocardial T<sub>1</sub> mapping using the slice‐interleaved T<sub>1</sub> (STONE) sequence

Weingärtner, Sebastian; Roujol, Sébastien; Akçakaya, Mehmet; Basha, Tamer; Nezafat, Reza

doi:10.1002/mrm.25387

Cited by 87 publications

(137 citation statements)

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“…MOLLI T 1 -times were obtained using standard post-processing [4] and SR T 1 -maps were generated using a three-parameter fit [18]. Regional ECV-values were calculated segment-wise according to the AHA 16-segment model [19] for both post-contrast time points.…”

Section: Methodsmentioning

confidence: 99%

Myocardial T1-mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

Weingärtner

Meßner

Budjan

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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BackgroundMyocardial T1-mapping recently emerged as a promising quantitative method for non-invasive tissue characterization in numerous cardiomyopathies. Commonly performed with an inversion-recovery (IR) magnetization preparation at 1.5T, the application at 3T has gained due to increased quantification precision. Alternatively, saturation-recovery (SR) T1-mapping has recently been introduced at 1.5T for improved accuracy.Thus, the purpose of this study is to investigate the robustness and precision of SR T1-mapping at 3T and to establish accurate reference values for native T1-times and extracellular volume fraction (ECV) of healthy myocardium.MethodsBalanced Steady-State Free-Precession (bSSFP) Saturation-Pulse Prepared Heart-rate independent Inversion-REcovery (SAPPHIRE) and Saturation-recovery Single-SHot Acquisition (SASHA) T1-mapping were compared with the Modified Look-Locker inversion recovery (MOLLI) sequence at 3T. Accuracy and precision were studied in phantom. Native and post-contrast T1-times and regional ECV were determined in 20 healthy subjects (10 men, 27 ± 5 years). Subjective image quality, susceptibility artifact rating, in-vivo precision and reproducibility were analyzed.ResultsSR T1-mapping showed <4 % deviation from the spin-echo reference in phantom in the range of T1 = 100–2300 ms. The average quality and artifact scores of the T1-mapping methods were: MOLLI:3.4/3.6, SAPPHIRE:3.1/3.4, SASHA:2.9/3.2; (1: poor - 4: excellent/1: strong - 4: none). SAPPHIRE and SASHA yielded significantly higher T1-times (SAPPHIRE: 1578 ± 42 ms, SASHA: 1523 ± 46 ms), in-vivo T1-time variation (SAPPHIRE: 60.1 ± 8.7 ms, SASHA: 70.0 ± 9.3 ms) and lower ECV-values (SAPPHIRE: 0.20 ± 0.02, SASHA: 0.21 ± 0.03) compared with MOLLI (T1: 1181 ± 47 ms, ECV: 0.26 ± 0.03, Precision: 53.7 ± 8.1 ms). No significant difference was found in the inter-subject variability of T1-times or ECV-values (T1: p = 0.90, ECV: p = 0.78), the observer agreement (inter: p > 0.19; intra: p > 0.09) or consistency (inter: p > 0.07; intra: p > 0.17) between the three methods.ConclusionsSaturation-recovery T1-mapping at 3T yields higher accuracy, comparable inter-subject, inter- and intra-observer variability and less than 30 % precision-loss compared to MOLLI.Electronic supplementary materialThe online version of this article (doi:10.1186/s12968-016-0302-x) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Myocardial T1-mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

Weingärtner

Meßner

Budjan

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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“…To assess LV/right ventricular myocardial function, geometry and mass, 10 to 12 short-axis stack images and 4-chamber cines were acquired using a breath-hold, ECG-gated steady state free precession sequence (slice thickness, 8-mm; gap, 2-mm, in-plane spatial resolution 2×2mm, 30 msec temporal resolution). Native T 1 map was acquired using a ECG-triggered, free-breathing slice-interleaved T 1 (STONE) sequence which enables acquisition of 5 slices in the short-axis plane within 90 sec (TR/TE=2.8/1.4 msec, flip angle=70°, FOV=360×351 mm, voxel size=2.1×2.1 mm, slice thickness=8 mm, TFE factor=86, SENSE factor=2) 17 . Then, 10 to 20 min after injected 0.1–0.2 mmol/kg of Gd-DTPA (Magnevist; Bayer Schering, Berlin, Germany) or Gd-BOPTA (MultiHance; Bracco Imaging SpA, Milan, Italy), short- and long-axis inversion recovery LGE images were acquired with a 3-dimensional phase sensitive inversion recovery sequence (PSIR) (5-mm slice thickness, TR/TE=5.3/2.1 msec, flip angle=70°, FOV=320×320×125 mm, acquisition matrix=224×224×23 and spatial resolution=1.4×1.4×1.5 mm).…”

Section: Methodsmentioning

confidence: 99%

Native T₁ value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction

Nakamori

Alakbarli

Bellm

et al. 2017

Magnetic Resonance Imaging

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Purpose To compare remote myocardium native T1 in patients with chronic myocardial infarction (MI) and controls without MI and to elucidate the relationship of infarct size and native T1 in the remote myocardium for the prediction of left ventricular (LV) systolic dysfunction after MI. Materials and Methods A total of 41 chronic MI (18 anterior MI) patients and 15 age-matched volunteers with normal LV systolic function and no history of MI underwent cardiac MR at 1.5 T. Native T1 map was performed using a slice interleaved T1 mapping and late gadolinium enhancement (LGE) imaging. Cine MR was acquired to assess LV function and mass. Results The remote myocardium native T1 time was significantly elevated in patients with prior MI, compared to controls, for both anterior MI and non-anterior MI (anterior MI:1099 ± 30, non-anterior MI:1097 ± 39, controls:1068 ± 25 msec, P <0.05). Remote myocardium native T1 moderately correlated with LV volume, mass index and ejection fraction (r=0.38, 0.50, −0.49, respectively, all p <0.05). LGE infarct size had a moderate correlation with reduced LV ejection fraction (r=−0.33, p<0.05), but there was no significant association between native T1 and infarct size. Native T1 time in the remote myocardium was independently associated with reduced LV ejection fraction, after adjusting for age, gender, infarct size and comorbidity (β=−0.34, p=0.03). Conclusion In chronic MI, the severity of LV systolic dysfunction after MI is independently associated with native T1 in the remote myocardium. Diffuse myocardial fibrosis in the remote myocardium may play an important pathophysiological role of post-MI LV dysfunction.

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“…The parameter estimation method (e.g. two-parameter vs threeparameter) can also influence the accuracy and precision of the maps (27). Physiological motion can be a major hurdle, with many sequences employing a breathhold and using ECG triggering to minimize motion artifacts.…”

Section: Introductionmentioning

confidence: 99%

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

et al. 2017

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Purpose-To introduce a 2D MR Fingerprinting technique for quantification of T 1 , T 2 , and M 0 in myocardium.Methods-An ECG-triggered MR Fingerprinting (MRF) method is introduced for mapping myocardial T 1 , T 2 , and M 0 during a single breathhold in as short as four heartbeats. The pulse sequence employs variable flip angles, repetition times, inversion recovery times, and T 2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate. Aspects of the sequence design were explored in simulations, and the accuracy and precision of cardiac MRF were assessed in a phantom study. In vivo imaging was performed at 3T in eleven volunteers to generate native parametric maps.Results-T 1 and T 2 measurements from the proposed cardiac MRF sequence correlated well with standard spin echo measurements in the phantom study (R 2 >0.99). A Bland-Altman analysis revealed good agreement for myocardial T 1 measurements between MRF and MOLLI (bias 1ms, 95% limits of agreement −72 to 72ms) and T 2 measurements between MRF and T 2 -prepared bSSFP (bias −2.6ms, 95% limits of agreement −8.5 to 3.3ms). Conclusions-MRFcan provide quantitative single slice T 1 , T 2 , and M 0 maps in the heart within a single breathhold.

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Free‐breathing multislice native myocardial T₁ mapping using the slice‐interleaved T₁ (STONE) sequence

Abstract: The STONE sequence allows accurate and precise quantification of native myocardial T times with the additional benefit of covering the entire ventricle. Magn Reson Med 74:115-124, 2015. © 2014 Wiley Periodicals, Inc.

Cited by 87 publications

References 36 publications

Myocardial T1-mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

Myocardial T1-mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

Native T₁ value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

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Free‐breathing multislice native myocardial T1 mapping using the slice‐interleaved T1 (STONE) sequence

Abstract: The STONE sequence allows accurate and precise quantification of native myocardial T times with the additional benefit of covering the entire ventricle. Magn Reson Med 74:115-124, 2015. © 2014 Wiley Periodicals, Inc.

Cited by 87 publications

References 36 publications

Myocardial T1-mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

Myocardial T1-mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

Native T1 value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density

Contact Info

Product

Resources

About

Free‐breathing multislice native myocardial T₁ mapping using the slice‐interleaved T₁ (STONE) sequence

Native T₁ value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density