Purpose-To compare higher spatial resolution 3D late gadolinium enhancement (LGE) cardiovascular MR (Cardiac MR) with 2D LGE in patients with prior myocardial infarction.Materials and Methods-Fourteen patients were studied using high spatial resolution 3D LGE (1.3×1.3× 5.0 mm 3 ) and conventional 2D LGE (2×2×8mm 3 ) scans. SNR and CNR were measured. Total infarct volume, peri-infarct volume measured in a limited slab, and papillary muscle scar volume were compared using Bland-Altman analysis. Image quality was graded.
Results-3DLGE had higher scar SNR (p<0.001), higher myocardial SNR (p=0.001), higher papillary scar-blood CNR (p=0.01), and greater sharpness (p=0.01). The scar volumes agreed (14.5±8.2 for 2D, vs. 13.2±8.8 for 3D), with bias ±2 SDs of 0.5±6.8ml, p=0.59 R=0.91. The periinfarct volumes correlated but less strongly than scar (p=0.40, R=0.77). For patients with more heterogeneous scar, larger peri-infarct volumes were measured by 3D (1.9±1.1ml for 2D vs. 2.4±1.6 ml for 3D, p=0.15, in the matched region). Papillary scar, present in 6/14 (42%) patients, was more confidently identified on 3D LGE.
Conclusion-Higher spatial resolution 3DLGE provides sharper images and higher SNR, but less myocardial nulling. Scar volumes agree well, with peri-infarct volumes correlating less well. 3D LGE may be superior in visualization of papillary muscle scar.