Free and nanoencapsulated curcumin prevents cigarette smoke-induced cognitive impairment and redox imbalance

Jaques, Jeandre Augusto dos Santos; Doleski, Pedro H.; Castilhos, Lívia Gelain; Rosa, Michelle Melgarejo da; Souza, Viviane do Carmo Gonçalves; Carvalho, Fabiano B.; Marisco, Patricia C.; Thorstenberg, Maria Luiza; Rezer, João Felipe Peres; Ruchel, Jader Betsch; Coradini, Karine; Beck, Ruy Carlos Ruver; Rubin, Maribel Antonello; Schetinger, Maria Rosa Chitolina; Leal, Daniela Bitencourt Rosa

doi:10.1016/j.nlm.2012.12.007

Cited by 35 publications

(31 citation statements)

References 59 publications

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“…In this study total-SH, protein-SH, and NP-SH levels were significantly lowered in the brain of rats exposed to cigarette smoke. These results are consistent with previous studies (Stangherlin et al 2009;Jaques et al 2013). Besides, these reports are in agreement with the finding above that the brain NO concentration is elevated in cigarette smoke-exposed rats, which enhances peroxynitrite and peroxynitrate formation and can subsequently deplete cellular thiols and promote apoptotic cell death (Pryor and Stone 1993).…”

Section: Discussionsupporting

confidence: 93%

“…In this study Na + /K + -ATPase activity was diminished while Na + level was elevated and K + concentration was lowered in the brain of cigarette smoke exposed rats. These results are consistent with earlier reports (Anbarasi et al 2005a;Jaques et al 2013). Besides, Tulenko et al (1988) also have shown decrease of Na + /K + -ATPase activity and increase of Na + level in arterial cell wall by exposure to cigarette smoke, which was attributed to the reorganization of lipid bilayer by increased TC/PL ratio.…”

Section: Discussionsupporting

confidence: 93%

“…This result was consistent with previous studies depicting that protein oxidation was elevated in cigarette smoke exposure Das et al 2009;Fraga et al 2011;Ozkol et al 2012). It was already showed that cigarette smoke causes increased generation of free radicals, mainly ROS, through the induction of various ROSproducing endogenous enzymes (Deliconstantinos and Villiotou 2000;Czekaj et al 2005;Das et al 2009;Khanna et al 2013;Jaques et al 2013). In agreement with their reports, the present results illustrated that Cyt P450, NADPH oxidase, and XO activities were increased in the brain of rats exposed to cigarette smoke.…”

Section: Discussionsupporting

confidence: 92%

“…In this study, we observed low Ca 2+ -ATPase activity and high Ca 2+ concentration in the brain of rats exposed to cigarette smoke. These results are concomitant with previous studies (Anbarasi et al 2005a;Jaques et al 2013). Calcium invasion followed by cigarette smoke exposure suppressed Ca 2+ -ATPase activity in the rat brain.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, the level of NO concentration also elevated in the brain of rats exposed to cigarette smoke this results are concomitant with earlier reports (Das et al 2009;Jaques et al 2013). Gas phase of cigarette smoke contains up to 500 ppm of NO, which can form peroxynitrite and peroxynitrate esters (Pryor and Stone 1993).…”

Section: Discussionsupporting

confidence: 89%

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Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

et al. 2015

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Cigarette smoking has been associated with high risk of neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis, etc., The present study was designed to evaluate the restorative effects of Sesbania grandiflora (S. grandiflora) on oxidative damage induced by cigarette smoke exposure in the brain of rats. Adult male Wistar-Kyoto rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with S. grandiflora aqueous suspension (SGAS, 1000 mg/kg body weight per day by oral gavage) for a period of 3 weeks. The levels of protein carbonyl, nitric oxide, and activities of cytochrome P450, NADPH oxidase and xanthine oxidase were significantly increased, whereas the levels of total thiol, protein thiol, non-protein thiol, nucleic acids, tissue protein and the activities of Na(+)/K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase were significantly diminished in the brain of rats exposed to cigarette smoke as compared with control rats. Also cigarette smoke exposure resulted in a significant alteration in brain total lipid, total cholesterol, triglycerides and phospholipids content. Treatment of SGAS is regressed these alterations induced by cigarette smoke. The results of our study suggest that S. grandiflora restores the brain from cigarette smoke induced oxidative damage. S. grandiflora could have rendered protection to the brain by stabilizing their cell membranes and prevented the protein oxidation, probably through its free radical scavenging and anti-peroxidative effect.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

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Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

et al. 2015

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Free and nanoencapsulated vitamin D₃: effects on E‐NTPDase and E‐ADA activities in an animal model with induced arthritis

Silveira

Thorstenberg

et al. 2016

Cell Biochemistry & Function

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Evaluation of the effects on the E-NTPDase and E-ADA activities in an animal model of induced arthritis. Two formulations of vitamin D3 were used: form oral solution and nanoencapsulated. Vitamin D3 seems to contribute to the inflammatory process induced by CFA. Vitamin D3 possibly alters the E-NTPDase and E-ADA activities. Vitamin D3 may be an alternative supplementary treatment for chronic arthritis.

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Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis

Oliveira

Stein

Andrade

et al. 2022

Phytotherapy Research

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Curcumin, a plant-derived compound, has various well-known biological effects (antiinflammatory, antioxidant, antitumor, among others) as well as some important limitations for formulators, such as poor water solubility and low oral bioavailability. Its nanoencapsulation is reported to overcome these drawbacks and to improve its in vivo efficacy. Here, data from preclinical in vivo studies evaluating the antitumor efficacy of curcumin-loaded polymeric nanocapsules are collected, analyzed, and discussed as a systematic review. Meta-analyses are performed to assess the contribution of this nanoencapsulation compared with nonencapsulated curcumin. Eighteen studies (116 animals) meet the inclusion criteria. The evidence that curcumin-loaded polymeric nanocapsules inhibits tumor growth (SMD: À3.03; 95% CI: À3.84, À2.21; p < 0.00001) and decreases tumor weight (SMD: À3.96; 95% CI: À6.22, À1.70; p = 0.0006) in rodents is established, regardless of the solid tumor model. To assess the quality of the studies included in the review a bias risk analysis was performed using the SYRCLE's RoB tool. Therefore, encapsulation in polymeric nanocapsules represents an important tool to improve the antitumor effects of curcumin, and this systematic review paves the way for future clinical studies and the translation of curcumin formulations into novel nanomedicines for human cancer treatment.

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Free and nanoencapsulated curcumin prevents cigarette smoke-induced cognitive impairment and redox imbalance

Cited by 35 publications

References 59 publications

Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

Free and nanoencapsulated vitamin D₃: effects on E‐NTPDase and E‐ADA activities in an animal model with induced arthritis

Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis

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Free and nanoencapsulated curcumin prevents cigarette smoke-induced cognitive impairment and redox imbalance

Cited by 35 publications

References 59 publications

Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats

Free and nanoencapsulated vitamin D3: effects on E‐NTPDase and E‐ADA activities in an animal model with induced arthritis

Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis

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Product

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Free and nanoencapsulated vitamin D₃: effects on E‐NTPDase and E‐ADA activities in an animal model with induced arthritis