Free and membrane-bound ribosomes and polysomes in hippocampal neurons during a learning experiment

Wenzel, J; David, Heinz; Pohle, W. D.; Marx, I; Matthies, H

doi:10.1016/0006-8993(75)90803-3

Cited by 13 publications

(3 citation statements)

References 38 publications

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“…The amounts of RNA and the size of nucleus and nucleolus can be easily evaluated in electron microscopic specimens by morphometric techniques (Weibel, Kistler & Scherle, 1966), in terms of density of ribosomes and endoplasmic reticulum and fraction of cell body occupied by nucleus, and nucleus occupied by the nucleolus. These methods can be readily employed in experimental situations and indeed have been used successfully to study the effects of learning on RNA metabolism and protein synthesis (Wenzel et al, 1975).…”

Section: Morphometric Approaches To Brain Functionmentioning

confidence: 99%

Annotation: Nerve Cell Protein Metabolism and Degenerative Disease

Mann

1982

Neuropathology Appl Neurobio

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The mechanisms and organelles through which control of protein synthesis within healthy nerve cells is governed are discussed, and the ways in which expression of these biochemical pathways can be related to cell morphology are described. The volumes of the nucleus and nucleolus, and the amount of RNA within the cell body, are all interrelated and seem to be set at genetically predetermined levels which normally match the neurones basal needs for replacement proteins in respect of the size of its' projection field. However, in situations of (induced) hyperactivity or cell damage, or in others where disease may lower nerve cell activity, the protein requirements change, and it is noted that these morphological features also alter in a direction appropriate to the need for greater or lesser amounts of protein. How these alterations in protein synthesis can provide information as to both the basic pathology, or even the pathogenesis, of degenerative disease of the nervous system is illustrated by reference to Alzheimer's disease and motor neurone disease.

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Section: Morphometric Approaches To Brain Functionmentioning

confidence: 99%

Annotation: Nerve Cell Protein Metabolism and Degenerative Disease

Mann

1982

Neuropathology Appl Neurobio

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“…But one should not forget the impressive collection of pioneering studies carried out by Dr. Wenzel and his colleagues in his earlier incarnation. This earlier work included a large number of articles in such journals as Zeitschrift für Mikroskopisch‐anatomische Forschung and Journal für Hirnforschung (Wenzel et al., 1969; Wenzel & Barlehner, 1969; Frotscher et al., 1970)—as well as in Brain Research (Wenzel et al., 1975, 1993) and Experimental Brain Research (Wenzel et al., 1977)—focusing on cortical and hippocampal anatomy, neuronal and synaptic development, regeneration, response to insult, and learning‐associated plasticity. In 1968, Wenzel brought the Golgi‐staining technique to Germany from Szentagothai’s laboratory in Budapest; Wenzel and his students subsequently published seminal Golgi‐based studies to describe the developing hippocampus (Minkwitz, 1976).…”

mentioning

confidence: 99%

“…With a focus on hippocampal synaptic transmission, Wenzel and his colleagues published important studies on dendritic spines and synapses (Wenzel et al., 1971/72, 1973, 1977), as well as a number of important papers characterizing the structure of hippocampal neurons and related brain regions (Dornig et al., 1976; Wenzel et al., 1981). Jürgen was also a pioneer in his focus on the potentially important role of glia in modulating synaptic function and plasticity—a conclusion he reached through careful anatomic investigation (Wenzel et al., 1975; Wenzel, 1977; Wenzel et al, 1977, 1980, 1991). He was an early investigator into the structural changes associated with brain trauma (such as hypoxia) in the developing brain (Frotscher et al., 1977; Meyer et al., 1986).…”

mentioning

confidence: 99%