Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma

Pollard, Suzanne L.; Lima, John J.; Mougey, Edward B.; Romero, Karina; Tarazona-Meza, Carla; Tomaino, Katherine; Guzmán, Gary Malpartida; Hansel, Nadia N.

doi:10.1016/j.anai.2017.04.021

Cited by 7 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The inconsistency between free and total level associations with response outcomes was unexpected given the predictions of the free hormone hypothesis and the strong relationship between C f and C tot (Figure 1). Additionally our observation does not agree with those of others reporting that free levels are better associated with skeletal markers, atopy and lung function in children with asthma compared to total levels 9–13 . We conclude that free concentrations of vitamin D 3 were inferior to total concentrations in associating responsiveness to vitamin D supplementation in the VIDA trial.…”

Section: Discussioncontrasting

confidence: 99%

“…In the present study C f and C tot were highly correlated (Figure 1, r=0.77), as reported in other studies 12,13,26 , yet, outcomes were associated with C tot levels > 30 ng/ml 25 but not with C f levels (Table 3). The reason(s) underlying this finding is not clear.…”

Section: Discussionsupporting

confidence: 90%

“…Consequently free vitamin D 3 concentrations are considered better markers of vitamin D status than total serum concentrations. Indeed several recent studies report that bone density and markers of bone turnover, as well as atopy and lung function in children with asthma are better correlated with bioavailable (free vitamin D 3 + bound to albumin) or with calculated or directly measured free vitamin D 3 concentrations than to total vitamin D 3 concentrations 9–13 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Lima

Castro

King

et al. 2018

Annals of Allergy, Asthma & Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Lima

Castro

King

et al. 2018

Annals of Allergy, Asthma & Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Bioavailable 25 (OH) D is believed to be free [26]. Increased DBP in the blood is thought to reduce free 25 (OH) D [27], and the association of free 25 (OH) D concentration with various diseases has been suggested [28, 29]. Together with the results of this study, vitamin D status seems to be a pivotal feature in AIS, and there is a possibility that DBP may be involved in the pathogenesis or severity of AIS.…”

Section: Discussionmentioning

confidence: 99%

Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Makino

Seki

Kitajima

et al. 2019

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, there are little evidences of the pathogenesis in patients with thoracolumbar/lumbar AIS. The purpose of this study was to identify proteins or proteomes that may be causally related to the pathogenesis of AIS with structured thoracolumbar/lumbar curvature using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Methods A total of 20 control volunteers and 61 AIS in patients with thoracolumbar/lumbar curvature were included. First, the plasma samples of each five AIS with pure thoracolumbar/lumbar curvature and control samples were subjected to 2D-DIGE analysis. Protein spots that were expressed differently by the AIS and control groups were selected and identified by nanoscale liquid chromatography–tandem mass spectrometry (nanoLC-MS/MS) analysis. To characterize the differently-expressed proteins in AIS patients, we performed functional pathway analysis using the Protein ANalysis THrough Evolutionary Relationships (PANTHER) system. Additionally, the proteins were compared between control and AIS using western blotting. Lastly, prospectively collected 15 control and 41 AIS with thoracolumbar/lumbar curvature samples were compared to the differentially expressed proteins. Results A total of 3862 ± 137 spots were detected, of which 11 spots met the criteria when compared with controls. Nine proteins were identified by nanoLC-MS/MS. Functional analysis showed the association of the proteins in AIS patients with blood coagulation using the PANTHER system. Of the proteins, vitamin D binding protein (DBP) significantly correlated with Cobb angle in thoracolumbar/lumbar curvatures. DBP expression of the prospectively collected AIS samples were significantly higher than those of controls ( P < 0.05). Conclusions This study suggests that DBP and several coagulation-related proteins may play a role in the pathogenesis of AIS. DBP appears to be a marker of severity of AIS with thoracolumbar/lumbar curvature.

show abstract

“…The publication of the parent study, GASP, is currently under review. However, two separate ancillary studies from the parent study have already been published 18,19 .…”

Section: Methodsmentioning

confidence: 99%

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Nicholson

Pollard

Lima

et al. 2017

Respiratory Medicine

Self Cite

View full text Add to dashboard Cite

Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR=1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

show abstract

Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma

Abstract: Atopy, forced expiratory volume in 1 second, and forced vital capacity were more strongly linked to free than to total 25(OH)D concentrations, suggesting the free form might be more relevant in modulating allergic disease risk and pulmonary function in children with asthma.

Cited by 7 publications

References 24 publications

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial

Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Contact Info

Product

Resources

About