This article reviews the contributions of the English neurophysiologist, Charles Scott Sherrington [1857-1952], and his Australian PhD trainee and collaborator, John Carew Eccles [1903-1997], to the concept of central inhibition in the brain and spinal cord of mammals. Both were awarded Nobel Prizes; Sherrington in 1932 for "discoveries regarding the function of neurons," and Eccles in 1963 for "discoveries concerning the ionic mechanisms involved in excitation and inhibition in central portions of the nerve cell membrane." Both spoke about central inhibition at their respective Nobel Prize Award Ceremonies. Their subsequent publications of these talks were entitled "Inhibition as a coordinative factor" (Sherrington) and "The ionic mechanism of postsynaptic inhibition" (Eccles). The span of Sherrington's work on central inhibition was 41 years (1893-1934), and for Eccles 49 years (1928-1977). Sherrington first studied central inhibition by observing hind limb muscle responses to electrical (peripheral nerve) and mechanical (muscle) stimulation. He used muscle length and force measurements until the early 1900s and electromyography in the late 1920s. Eccles used these techniques while working with Sherrington, but later used extracellular microelectrode recording in the spinal cord followed in 1951 by copioneering intracellular recording from spinal motoneurons to considerably advance understanding of central inhibition. Sherrington's health was poor during his retirement years but he nonetheless made a small number of largely humanities contributions up to 1951, one year before his death at the age of 94. In contrast, Eccles retained his health and vigor until about 3 years before his death, and published prolifically on many subjects throughout his 22 years of 'official' retirement. His last neuroscience article appeared in 1994 when he was 91. Despite his afflictions there is evidence that he continued thinking about his lifelong interest, the mind-brain problem and was attempting to complete his autobiography until his death at the age of 93. To Brain Research 6 with Friedrich Goltz (see 7.1 below) at the University of Strasbourg, which was then part of Germany. His post-M.B. training in 1886-1887 was in bacteriology, neurohistology, and pathology rather than physiology. It was undertaken with Robert Koch (see 6.1.4.) at the University of Berlin. Sherrington's academic (including teaching) postings were, in their order, at: StTHMS, as an anatomy demonstrator (1883-1884), and later as a lecturer in physiology (1887-1895); in parallel positions at Cambridge as a research fellow and tutor (same time span), and as Physician-Superintendent at the Brown Institution of Preventative Medicine, a University of London veterinary facility (1891-1895); the University of Liverpool as the Professor of Physiology (1895-1912); and finally, the University of Oxford, again as the Professor of Physiology (1913-1935). He resigned his Oxford professorship at the end of 1935 due to severe arthritis (see 6.1.3.), and left the city at...