Framework for lumen-based nonrigid tomographic coregistration of intravascular images

Karmakar, Abhishek; Olender, Max L.; Marlevi, David; Shlofmitz, Evan; Shlofmitz, Richard; Edelman, Elazer R.; Nezami, Farhad Rikhtegar

doi:10.1117/1.jmi.9.4.044006

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…3D model reconstruction was achieved by fusing the IV-OCT and DSA images using a rigid registration method and based on an assumption of a constant speed of pullback. Interpolation operations and key landmarks were used in this study to reduce imprecisions; however, non-rigid registration should be adopted ( 55 , 56 ). The one-way steady FSI simulation failed to consider the influence of the pulse pressure wave and the deformation of the vessel wall, which might have led to mis-estimates of the functional parameters.…”

Section: Discussionmentioning

confidence: 99%

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Zhang,

Nan,

Tong

et al. 2024

Quant Imaging Med Surg

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Background It has been suggested that biomechanical factors may influence plaque development. However, key determinants for assessing plaque vulnerability remain speculative. Methods In this study, a two-dimensional (2D) structural mechanical analysis and a three-dimensional (3D) fluid-structure interaction (FSI) analysis were conducted based on intravascular optical coherence tomography (IV-OCT) and digital subtraction angiography (DSA) data sets. In the 2D study, 103 IV-OCT slices were analyzed. An in-depth morpho-mechanic analysis and a weighted least absolute shrinkage and selection operator (LASSO) regression analysis were conducted to identify the crucial features related to plaque vulnerability via the tuning parameter (λ). In the 3D study, the coronary model was reconstructed by fusing the IV-OCT and DSA data, and a FSI analysis was subsequently performed. The relationship between vulnerable plaque and wall shear stress (WSS) was investigated. Results The influential factors were selected using the minimum criteria (λ-min) and one-standard error criteria (λ-1se). In addition to the common vulnerable factor of the minimum fibrous cap thickness (FCTmin), four biomechanical factors were selected by λ-min, including the average/maximal displacements and average/maximal stress, and two biomechanical factors were selected by λ-1se, including the average/maximal displacements. Additionally, the positions of the vulnerable plaques were consistent with the sites of high WSS. Conclusions Functional indices are crucial for plaque status assessment. An evaluation based on biomechanical simulations might provide insights into risk identification and guide therapeutic decisions.

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Section: Discussionmentioning

confidence: 99%

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Zhang,

Nan,

Tong

et al. 2024

Quant Imaging Med Surg

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“…However, the complex structure of intraluminal tissues 14 and their dynamic nature 15 , as well as the mechanical rotational resistance encountered during imaging, impose significant challenges to the popular proximal scanning mode of OCT endoscope 12 . This mode involves the transmission of torque from a proximal motor via a torsion spring, and it is not applicable for deployment in certain in-vivo settings 12 .…”

Section: Introductionmentioning

confidence: 99%

Motor-free telerobotic endomicroscopy for steerable and programmable imaging in complex curved and localized areas

Ren,

Yuan,

et al. 2024

Preprint

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Aberrations in intraluminal epithelia are precursors to a plethora of critical conditions, including various cancers, where early detection is crucial for patient prognosis. Optical Coherence Tomography (OCT) endoscopy has emerged as a promising imaging technique that provides high resolution in micrometers and imaging depth in millimeters. However, conventional proximal-scanning OCT endoscopes face challenges in imaging tortuous lumens. Motor-driven distal-scanning OCT endoscopes afford potential solutions but pose thermal and electrical risks to tissues. Crucially, these systems lack the requisite compact steering mechanisms for effective navigation within complex luminal organs, commonly involving tooltip deformations, including bending, torsion, and compression. Here, we present a motor-free telerobotic OCT endoscope of a 1.28 ~ 2.28-mm long magnetic rotator integrating a rotatable diametrically magnetized cylinder permanent magnet (RDPM) with a light reflector. Utilizing an external magnetic field effectively mitigates heat effects induced by current and voltage, yielding a maximum voltage of less than 0.02 mV and a temperature rise of no more than 0.5 °C even during continuous operation lasting one hour. Furthermore, a learning-based approach is developed to correct the common OCT imaging distortions resulting from nonuniform rotation within curved luminal organs. The endoscope demonstrates remarkable maneuverability, enabling steerable angles up to 110° under a magnetic field strength of ~ 500 mT and a gradient of ~ 0.06 mT/mm. In-vivo studies on mouse colons validate the endoscope's ability to deliver reliable angular control for localized 3D imaging, unaffected by bending and without the need for feedback. This advancement in intraluminal microimaging introduces a new guidewire-independent technique in endomicroscopy, enhancing safety and potentially improving patient care.

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Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

Straughan

Kadry

Edelman

et al. 2023

Computers in Biology and Medicine

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Framework for lumen-based nonrigid tomographic coregistration of intravascular images

Cited by 4 publications

References 31 publications

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Motor-free telerobotic endomicroscopy for steerable and programmable imaging in complex curved and localized areas

Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

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