Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

Straughan, Ross; Kadry, Karim; Edelman, Elazer R.; Nezami, Farhad Rikhtegar

doi:10.1016/j.compbiomed.2023.107341

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…However, the FSI simulation took around 6 hours to obtain the functional parameters in this study, and thus is time-consuming and not suitable for real-time analysis. Automatic frameworks should be applied in the future to enable the integration of plaque stress analysis in the clinic ( 52 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Zhang,

Nan,

Tong

et al. 2024

Quant Imaging Med Surg

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Background It has been suggested that biomechanical factors may influence plaque development. However, key determinants for assessing plaque vulnerability remain speculative. Methods In this study, a two-dimensional (2D) structural mechanical analysis and a three-dimensional (3D) fluid-structure interaction (FSI) analysis were conducted based on intravascular optical coherence tomography (IV-OCT) and digital subtraction angiography (DSA) data sets. In the 2D study, 103 IV-OCT slices were analyzed. An in-depth morpho-mechanic analysis and a weighted least absolute shrinkage and selection operator (LASSO) regression analysis were conducted to identify the crucial features related to plaque vulnerability via the tuning parameter (λ). In the 3D study, the coronary model was reconstructed by fusing the IV-OCT and DSA data, and a FSI analysis was subsequently performed. The relationship between vulnerable plaque and wall shear stress (WSS) was investigated. Results The influential factors were selected using the minimum criteria (λ-min) and one-standard error criteria (λ-1se). In addition to the common vulnerable factor of the minimum fibrous cap thickness (FCTmin), four biomechanical factors were selected by λ-min, including the average/maximal displacements and average/maximal stress, and two biomechanical factors were selected by λ-1se, including the average/maximal displacements. Additionally, the positions of the vulnerable plaques were consistent with the sites of high WSS. Conclusions Functional indices are crucial for plaque status assessment. An evaluation based on biomechanical simulations might provide insights into risk identification and guide therapeutic decisions.

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Section: Discussionmentioning

confidence: 99%

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Zhang,

Nan,

Tong

et al. 2024

Quant Imaging Med Surg

View full text Add to dashboard Cite

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Patient digital twins: an introduction based on a scoping review (Preprint)

Drummond,

Gonsard

2024

Preprint

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UNSTRUCTURED The concept of digital twins, widely adopted in industry, is entering healthcare. In this scoping review, we analysed definitions and characteristics of patient digital twins being developed for clinical use. Searching for studies claiming digital twin development/evaluation until August 2023, we identified 86 articles representing 80 unique claimed digital twins, nearly all (98%) in preclinical phases. From the analysis of definitions and characteristics, we propose to define patient digital twin as “a viewable digital replica of a patient, organ, or biological system that contains multidimensional, patient-specific information”. Two main forms were found: simulation digital twins using computational modelling of patient anatomy/physiology to run personalised outcome predictions and therapy evaluations, mostly for one-time assessments; and monitoring digital twins harnessing aggregated patient data for continuous risk/outcome forecasting over time and care optimisation. As patient digital twins rapidly emerge, the proposed definitions and subtypes offer a framework to guide research into realising the potential of these personalised, integrative technologies to advance clinical care.

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Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

Cited by 2 publications

References 38 publications

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography

Patient digital twins: an introduction based on a scoping review (Preprint)

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