Frailty in People Living with HIV

Falutz, Julian

doi:10.1007/s11904-020-00494-2

Cited by 23 publications

(32 citation statements)

References 128 publications

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“…These changes lead to increased connectivity of symptoms and a high possibility of "negative spiral loops" of symptoms, where a deterioration in one symptom may lead to deterioration in others (Hwang et al, 2017;Zhou et al, 2014). Falutz used the term "physical frailty" to describe this phenomenon of physical challenges faced by long-term survivors (Falutz, 2020). To the best of our knowledge, this is the first study to capture the changes in symptom networks in long-term survivors quantitatively.…”

Section: Discussionmentioning

confidence: 99%

Evolving symptom networks in relation to HIV-positive duration among people living with HIV: A network analysis

Zhu

Wen

Yang

et al. 2021

International Journal of Infectious Diseases

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To explore and visualize the relationships among multiple symptoms in people living with HIV (PLWH) and compare centrality indices and the density of symptom networks among groups of individuals with different HIV-positive durations. Methods: We conducted a secondary analysis of data from the HIV-related Symptoms Monitoring Survey conducted in China. Networks were constructed among 27 symptoms. Centrality properties, including strength and closeness, and network density were used to describe relationships among symptoms in 5 different HIV-positive duration groups. Results: The findings showed that PLWH with longer HIV-positive durations did not have more severe symptoms; instead, their symptom networks were denser than those of their newly HIV-diagnosed counterparts (F = 27.073, P < 0.001). Fatigue was the most severe and central symptom in PLWH with an HIV-positive duration <10 years (r S = 7.79-10.09, r B = 18-44, r C = 0.01). Confusion was the most central symptom across the 3 centrality indices (r S = 11.81, r B = 14.00, r C = 0.02) in PLWH who had HIV-positive durations >10 years. Conclusion:This study demonstrates a need to include an assessment of PLWH symptom networks as an essential component of HIV care. We recommended evaluating cognitive function and cognitive training as essential components of HIV care for long-term survivors, even in younger populations (aged 50 years).

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Section: Discussionmentioning

confidence: 99%

Evolving symptom networks in relation to HIV-positive duration among people living with HIV: A network analysis

Zhu

Wen

Yang

et al. 2021

International Journal of Infectious Diseases

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“…Classical biomarkers of systemic inflammation such as IL-6, C-reactive protein (CRP) and D-dimers, as well as a low CD4/CD8 ratio and high markers of immune activation (CD8+/CD38+, CD8+/HLA-DR+) have been associated with frailty in the HIV population. 98 Some SNPs in IL-6 and IL-10 have been correlated with higher epigenetic age and the IL-6 C allele carriers had an increased risk of suffering non-AIDS conditions. 99 IL-6 and IL-10 SNPs may help to identify PLWH who are at high risk for accelerated ageing.…”

Section: Molecular and Cellular Biomarkers In Hiv Ageingmentioning

confidence: 99%

Ageing with HIV: Challenges and biomarkers

et al. 2022

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“…26 Use of antiretroviral therapy can reduce the occurrence of frailty. 27 Early and prompt diagnosis for individuals with undiagnosed HIV infection can reduce or minimize the occurrence of frailty.…”

Section: Antiretroviral Therapymentioning

confidence: 99%

Frailty in Adults With HIV: Identification, Assessment, and Management

Kwong¹

2022

The Journal for Nurse Practitioners

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Frailty in People Living with HIV

Cited by 23 publications

References 128 publications

Evolving symptom networks in relation to HIV-positive duration among people living with HIV: A network analysis

Evolving symptom networks in relation to HIV-positive duration among people living with HIV: A network analysis

Ageing with HIV: Challenges and biomarkers

Frailty in Adults With HIV: Identification, Assessment, and Management

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