Ageing with HIV: Challenges and biomarkers

Rodés, Berta; Cadiñanos, Julen; Esteban-Cantos, Andrés; Rodríguez-Centeno, Javier; Arribas, José Ramón

doi:10.1016/j.ebiom.2022.103896

Cited by 39 publications

(38 citation statements)

References 104 publications

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“…The rising mortality rate among PWID in 2012–2016 in the present study may be due to a cohort effect stemming from the CRF07_BC epidemic in 2003. Considering the slow immunological progression caused by HIV CRF07_BC strain 40 , premature aging among PLWH 41 , and higher exposure to harmful lifestyles among PWID 9 , 10 , 13 , 41 , non-AIDS-related deaths are postulated to be the primary category of rising mortality observed in 2012–2016. In summary, to further reduce mortality in PLWH in Taiwan, strategies should be tailored to specific transmission categories: optimizing measures to expand targeted HIV testing for sexually at-risk populations to enhance early diagnosis of HIV infection, and intensifying surveillance of non-AIDS comorbidities and interventions to reduce harmful lifestyles among PWID PLWH.…”

Section: Discussionmentioning

confidence: 99%

Sex stratification of the trends and risk of mortality among individuals living with HIV under different transmission categories

Lee

Lin

et al. 2022

Sci Rep

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We retrospectively examined 33,142 persons living with HIV (PLWH) in Taiwan from a nationwide database to assess sex-stratified trends and risk of all-cause mortality under different transmission categories from 1984 to 2016. Overall, 61.25% were men who have sex with men (MSM), 14.37% were men who have sex with women (MSW), 18.32% were male persons who inject drugs (M-PWID), 3.30% were women who have sex with men (WSM), and 2.74% were female PWID (F-PWID). All-cause mortality (per 100 person-years) among heterosexual people and PWID was higher in men (4.04 and 3.39, respectively) than in women (2.93 and 2.18, respectively). In each sex-stratified transmission category, the all-cause mortality reduced substantially from 1984–1996 to 2012–2016, but evolved distinctly from 2007–2011 to 2012–2016. Since 2007–2011, the decline in all-cause mortality has slowed notably in the groups with sexually transmitted HIV, but has increased in PWID, surpassing even that among groups with sexually transmitted HIV in 2012–2016. PLWH with sexually transmitted HIV had lower risks of all-cause mortality than PWID, regardless of sex. Sex and transmission category did not interact significantly on all-cause mortality. Understanding the reasons for the distinct evolving trends of all-cause mortality in each transmission category serves as a reference for developing strategies to reduce mortality in PLWH in Taiwan further.

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Section: Discussionmentioning

confidence: 99%

Sex stratification of the trends and risk of mortality among individuals living with HIV under different transmission categories

Lee

Lin

et al. 2022

Sci Rep

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“…This suggests there may be a shared proteomic pattern between PWH and people without HIV when they are growing older. Many current research efforts have focused on developing age-associated biomarkers, such as epigenetic "clocks" based on changes in DNA methylation level 7 .…”

Section: Discussionmentioning

confidence: 99%

“…With the introduction of effective antiretroviral therapy (ART), HIV-related mortality has been substantially reduced 2 . However, prolonged survival with HIV infection has been associated with an increased risk of age-related comorbidities such as hypertension, cardiovascular diseases, diabetes, and cancers compared to agematched individuals without HIV infection [3][4][5][6][7][8] . This health impact is significant for populations with highly prevalent and prolonged HIV epidemics such as the population of South Africa 9 .…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we profiled 92 inflammation-related protein markers in the plasma to assess their associations with chronological age, sex and CD4+ T-cell count among 87 black South African PWH prior to initiating ART. We focused only on treatment naïve patients because the toxicities induced by ART and the time on treatment can affect aging in PWH 7 , which could complicate the testing and interpretation of phenotype-protein associations in PWH. We identified statistically significant associations of inflammatory proteins which are also linked to chronic diseases such as cardiovascular disease and neurocognitive decline.…”

Section: Introductionmentioning

confidence: 99%

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Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa

Chen

Hui

Liu

et al. 2022

Preprint

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Elevated levels of inflammation associated with HIV infection are considered one of the primary causes for the excess burden of age-related morbidity and mortality among people with HIV (PWH). Circulating protein levels can be used to investigate biological pathways contributing to persistent inflammation among PWH. In this study, we profiled 73 inflammation-related protein markers and assessed their associations with chronological age, sex and CD4+ cell count among 87 black South African PWH prior to initiating ART. We identified 1, 1 and 14 inflammatory proteins significantly associated with sex, CD4+ T-cell count, and age respectively among PWH. Twelve out of 14 age-associated proteins have been reported to be associated with age in the general population, and 4 have previously shown significant associations with age for PWH. Furthermore, many of the age-associated proteins such as CST5, CCL23, SLAMF1, MMP-1, MCP-1, and CDCP1 have been linked to chronic diseases such as cardiovascular disease and neurocognitive decline in the general population. We also found a synergistic interaction between male sex and older age accounting for excessive expression of CST5. In conclusion, we found that age may lead to the elevation of multiple inflammatory proteins among PWH. We also demonstrated the potential utility of proteomics for evaluating and characterizing the inflammatory status among PWH.

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“…People living with HIV (PLWH) have increased rates of age-related comorbidities compared to the general population [ 1 , 2 ]. Aging characteristics are heterogeneous among PLWH [ 3 , 4 ], therefore, the identification of risk factors related to adverse outcomes with aging including cardiovascular diseases, neurocognitive impairment (NCI) and frailty has become increasingly relevant for the older PLWH population.…”

Section: Introductionmentioning

confidence: 99%

Association of Phenotypic Aging Marker with comorbidities, frailty and inflammatory markers in people living with HIV

et al. 2022

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Background Aging characteristics in people living with HIV (PLWH) are heterogeneous, and the identification of risk factors associated with aging-related comorbidities such as neurocognitive impairment (NCI) and frailty is important. We evaluated predictors of novel aging markers, phenotypic age (PhenoAge) and phenotypic age acceleration (PAA) and their association with comorbidities, frailty, and NCI. Methods In a cohort of PLWH and age- and sex-matched HIV-negative controls, we calculated PhenoAge using chronological age and 9 biomarkers from complete blood counts, inflammatory, metabolic-, liver- and kidney-related parameters. PAA was calculated as the difference between chronological age and PhenoAge. Multivariate logistic regression models were used to identify the factors associated with higher (>median) PAA. Area under the receiver operating characteristics curve (AUROC) was used to assess model discrimination for frailty. Results Among 333 PLWH and 102 HIV-negative controls (38% female), the median phenotypic age (49.4 vs. 48.5 years, p = 0.54) and PAA (− 6.7 vs. -7.5, p = 0.24) was slightly higher and PAA slightly less in PLWH although this did not reach statistical significance. In multivariate analysis, male sex (adjusted odds ratio = 1.68 [95%CI = 1.03–2.73]), current smoking (2.74 [1.30–5.79]), diabetes mellitus (2.97 [1.48–5.99]), hypertension (1.67 [1.02–2.72]), frailty (3.82 [1.33–10.93]), and higher IL-6 levels (1.09 [1.04–1.15]), but not HIV status and NCI, were independently associated with higher PAA. PhenoAge marker discriminated frailty better than chronological age alone (AUROC: 0.75 [0.66–0.85] vs. 0.65 [0.55–0.77], p = 0.04). In the analysis restricted to PLWH, PhenoAge alone predicted frailty better than chronological age alone (AUROC: 0.7412 vs. 0.6499, P = 0.09) and VACS index (AUROC: 0.7412 vs. 0.6811, P = 0.34) despite not statistically significant. Conclusions While PLWH did not appear to have accelerated aging in our cohort, the phenotypic aging marker was significantly associated with systemic inflammation, frailty, and cardiovascular disease risk factors. This simple aging marker could be useful to identify high-risk PLWH within a similar chronological age group.

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Ageing with HIV: Challenges and biomarkers

Cited by 39 publications

References 104 publications

Sex stratification of the trends and risk of mortality among individuals living with HIV under different transmission categories

Sex stratification of the trends and risk of mortality among individuals living with HIV under different transmission categories

Associations of inflammation-related proteome with demographic and clinical characteristics of people with HIV in South Africa

Association of Phenotypic Aging Marker with comorbidities, frailty and inflammatory markers in people living with HIV

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