Frailty and nutrition: Searching for evidence

Bonnefoy, Marc; Berrut, Gilles; Lesourd, B.; Ferry, M.; Gilbert, Thomas; Guérin, Olivier; Hanon, Olivier; Jeandel, Claude; Paillaud, Éléna; Raynaud-Simon, A.; Ruault, Geneviève; Rolland, Yves

doi:10.1007/s12603-014-0568-3

Cited by 146 publications

(100 citation statements)

References 109 publications

(119 reference statements)

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“…Recent studies suggest that improving nutritional status may reduce the risk of frailty. 95,96 Furthermore, a recent review has shown that nutrition may improve the functional outcome of elderly and frail patients. 97 …”

mentioning

confidence: 99%

Frailty and cardiac rehabilitation: A call to action from the EAPC Cardiac Rehabilitation Section

Vigorito

Abreu

Ambrosetti³

et al. 2016

Eur J Prev Cardiolog

160

130

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Frailty is a geriatric syndrome characterised by a vulnerability status associated with declining function of multiple physiological systems and loss of physiological reserves. Two main models of frailty have been advanced: the phenotypic model (primary frailty) or deficits accumulation model (secondary frailty), and different instruments have been proposed and validated to measure frailty. However measured, frailty correlates to medical outcomes in the elderly, and has been shown to have prognostic value for patients in different clinical settings, such as in patients with coronary artery disease, after cardiac surgery or transvalvular aortic valve replacement, in patients with chronic heart failure or after left ventricular assist device implantation. The prevalence, clinical and prognostic relevance of frailty in a cardiac rehabilitation setting has not yet been well characterised, despite the increasing frequency of elderly patients in cardiac rehabilitation, where frailty is likely to influence the onset, type and intensity of the exercise training programme and the design of tailored rehabilitative interventions for these patients. Therefore, we need to start looking for frailty in elderly patients entering cardiac rehabilitation programmes and become more familiar with some of the tools to recognise and evaluate the severity of this condition. Furthermore, we need to better understand whether exercise-based cardiac rehabilitation may change the course and the prognosis of frailty in cardiovascular patients.

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mentioning

confidence: 99%

Frailty and cardiac rehabilitation: A call to action from the EAPC Cardiac Rehabilitation Section

Vigorito

Abreu

Ambrosetti³

et al. 2016

Eur J Prev Cardiolog

160

130

View full text Add to dashboard Cite

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“…Even in the frail group, the respective value was 1.40 g/kg BW/d. Previous review studies showed that some study described the daily protein intake of 0.8 g/kg BW/d is insufficient for the maintenance of muscle mass and proposed 1.0–1.5 g/kg BW/d among old population [10, 12]. Although we cannot adequately discuss the appropriate amount of protein intake in this study due to the limited validity of the BDHQ, the amount of protein required to maintain muscle mass for old population might be higher than the present recommendation in Japan.…”

Section: Discussionmentioning

confidence: 99%

Diet with a combination of high protein and high total antioxidant capacity is strongly associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study

Kobayashi

Suga

Sasaki

2017

Nutr J

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BackgroundThe intake of protein and antioxidants has been inversely associated with frailty, individually. However, to our knowledge, no study has evaluated these associations in considering antioxidants or protein intakes as respective confounders. Further, the cooperative effect of dietary protein and antioxidants on frailty has not been investigated. Therefore, we examined the association of high protein and high dietary total antioxidant capacity (TAC) with frailty under the adjustment for dietary TAC or protein intake, respectively. The association between the combination of high dietary protein and high dietary TAC and frailty was also investigated.MethodsA total of 2108 grandmothers or acquaintances of dietetic students aged 65 years and older participated in this cross-sectional multicenter study conducted in 85 dietetic schools in Japan. Dietary variables, including protein intake, and dietary TAC were estimated from a validated brief-type self-administered diet history questionnaire. Frailty was defined as a score of three or more points obtained from the following four components: slowness and weakness (two points), exhaustion, low physical activity, and unintentional weight loss.ResultsMedian (interquartile range) age of the present subjects was 74 (71–78) years. Multivariate adjusted ORs (95% CIs) for frailty in the highest compared to the lowest tertile were 0.66 (0.49, 0.87) for total protein intake (P for trend = 0.003) and 0.51 (0.37, 0.69) for dietary TAC (P for trend <0.0001) after adjustment for dietary TAC or total protein intake, respectively. The OR of frailty for the group with both the highest tertiles of total protein intake and dietary TAC was markedly lower (multivariate adjusted OR [95% CIs]: 0.27 [0.16, 0.44]; P <0.0001) compared to the group with the lowest tertile of protein intake and the lowest tertile of dietary TAC.ConclusionsBoth protein intake and dietary TAC were independently inversely associated with frailty among old Japanese women. Further, a diet with the combination of high dietary protein and high dietary TAC was strongly inversely associated with the prevalence of frailty in this population. To select food combinations that allow for an increase of both protein and antioxidants in diet according to the local food culture and dietary habits may be an effective strategy for frailty prevention.

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“…The Asia Pacific Conference has developed guidelines for the treatment of frailty (83). A Mediterranean diet and polyphenols appear to decrease the chance of developing frailty (84)(85)(86)(87).…”

Section: Modern Geriatric Giantsmentioning

confidence: 99%