Frailty and malnutrition predictive of mortality risk in older patients with advanced colorectal cancer receiving chemotherapy

Utility of the Edmonton Frail Scale in identifying frail elderly patients during treatment of colorectal cancer

“…The resulting score from 0-17 categorizes patients as not frail [0-4], vulnerable [5][6], mild frailty [7][8], moderate frailty [9][10], and severe frailty (>11) (19). The treating oncology team, including the Nurse and the Medical Oncologist, and the patient were blinded to the EFS score.…”

“…Since there is significant heterogeneity in health status among elderly patients with CRC, chronological age alone is an insufficient measure of "fitness" for chemotherapy (6). In the geriatric literature, the concept of "frailty" has been postulated as a better indicator of "functional age" of the patients (7,8) and studies have suggested frailty to be a better predictor of mortality and treatment response than age (9). However, there is still considerable debate surrounding both its definition and the methods by which to measure it.…”

Depression and appetite: predictors of malnutrition in gynecologic cancer

“…In addition, changes in protein metabolism may provoke loss of appetite and body weight as well as cachexia [5]. As a result, malnutrition results in poor clinical outcomes, such as prolonged length of hospital stay [13] and high mortality in cancer patients [14]. Therefore, malnutrition is a major problem for cancer patients in general, and the same is true for gynecologic cancer patients.…”

Palliative Chemotherapy for Patients 70 Years of Age and Older with Metastatic Colorectal Cancer: A Single-Centre Experience

“…mortality 17,18 . Too many data on adl and iadl were missing to evaluate functional status in our patients.…”