FRAIL Questionnaire Screening Tool and Short-Term Outcomes in Geriatric Fracture Patients

Gleason, Lauren J.; Benton, Emily A.; Álvarez-Nebreda, M.L.; Weaver, Michael J.; Harris, Mitchel B.; Javedan, Houman

doi:10.1016/j.jamda.2017.07.005

Cited by 123 publications

(134 citation statements)

References 39 publications

(34 reference statements)

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“…Of studies not included in the meta‐analysis, 9 did not evaluate delirium as an incident phenomenon, 2 did not specify the method used to classify delirium, and 1 used an ambiguous method to define frailty (used to classify frail participants was not mutually exclusive to other participants in the study).…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies were conducted in acute hospital wards, and 1 involved individuals at home after discharge from an acute hospital . One study focused on individuals with atrial fibrillation; 1 on individuals admitted to a vascular surgical ward; 2 on individuals with cancer, organ failure, or mixed conditions; 1 on individuals admitted to intensive care units (ICU); 3 on individuals with a mix of geriatric, medical, and surgical conditions; and 2 on individuals with hip fracture; 2 studies did not specify the main diagnoses …”

Section: Resultsmentioning

confidence: 99%

“…To assess frailty, 3 studies used tools based on the deficit accumulation hypothesis (Frailty Index),, 3 defined frailty based upon the results of the Comprehensive Geriatric Assessment, 2 used the Edmonton Frailty Scale, 1 used a modified Frailty Phenotype, 1 used the Clinical Frailty Scale, and 1 used the results of the 5‐question Frail Scale …”

Section: Resultsmentioning

confidence: 99%

“…To assess delirium, 5 studies used the Confusion Assessment Method (CAM), 1 the CAM for the ICU (CAM‐ICU), 1 the Delirium Rating Scale (DRS)‐R98, 1 the interRAI‐ Acute Care for Comprehensive Geriatric Assessment (with 2 items used as a screening tool for delirium), and 1 the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) criteria; 3 studies did not specify the delirium assessment method,. The prevalence of frailty in these studies ranged from 23% to 78%.…”

Section: Resultsmentioning

confidence: 99%

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Frailty and Delirium in Older Adults: A Systematic Review and Meta‐Analysis of the Literature

Persico

Cesari

Morandi

et al. 2018

J American Geriatrics Society

147

109

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OBJECTIVES To evaluate the relationship between frailty and delirium. DESIGN Systematic review and meta‐analysis. SETTING MEDLINE, EMBASE, PubMed, Scopus, Web of Science, and Google Scholar databases were searched for articles on frailty and delirium published on or before October 31, 2017. PARTICIPANTS Individuals aged 65 and older. MEASUREMENTS Two authors independently reviewed all English‐language citations, extracted relevant data, and assessed studies for potential bias. Articles involving pediatric or neurosurgical populations, alcohol or substance abuse, psychiatric illness, head trauma, or stroke, as well as review articles, letters, and case reports were excluded. Studies underwent qualitative or quantitative analysis according to specified criteria. Using a random‐effects or fixed‐effects model, relative risk (RR) was calculated for the effect of frailty as a predictor of subsequent delirium. Heterogeneity was tested using Q and I2 statistics. RESULTS We identified 1,626 articles from our initial search, of which 20 fulfilled the selection criteria (N=5,541 participants, mean age 77.8). Eight studies were eligible for meta‐analysis, showing a significant association between Q2 frailty and subsequent delirium (RR = 2.19, 95% confidence interval = 1.65–2.91). There was low variability among studies in the measures of association between frailty and delirium (I2 2.24, p‐value Q‐statistic = .41) but high heterogeneity in the methods used to assess the two conditions. CONCLUSION This systematic review and meta‐analysis supports the existence of an independent relationship between frailty and delirium, although there is notable methodological heterogeneity between the methods used to assess the 2 conditions. Future studies are needed to better delineate the dynamics between these syndromes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Frailty and Delirium in Older Adults: A Systematic Review and Meta‐Analysis of the Literature

Persico

Cesari

Morandi

et al. 2018

J American Geriatrics Society

147

109

View full text Add to dashboard Cite

show abstract

“…Studies have suggested that exercise and nutrition interventions can improve outcomes in frail older persons (72)(73)(74)(75). A rapid screen -the FRAIL -can be utilized both in hospitals (76,77) and in the outpatient setting (78)(79)(80)(81). A computerized algorithm has been developed to allow health professionals to recognize and treat frailty (82).…”

Section: Modern Geriatric Giantsmentioning

confidence: 99%

Geriatrics in the 21st century

Vellas

Morley

2018

The Journal of nutrition, health and aging

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A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort

Thompson,

Thanik,

Sabra

et al. 2024

American J Industrial Med

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BackgroundGiven the significant exposures experienced by the World Trade Center (WTC) general responders, there is increasing interest in understanding the effect of these exposures on aging in this population. We aim to identify factors that may be associated with frailty, a clinical syndrome characterized by a decrease in one's reserve that has been linked to poor health outcomes.MethodsWTC general responders enrolled in the WTC Health Program aged 50 and older provided informed consent. Validated frailty assessments, the Frailty Phenotype (with the Johns Hopkins Frailty Assessment Calculator) along with the FRAIL scale, categorized nonfrail from prefrail/frail. Fall risk, functional status, and cognition were also assessed. WTC variables, including an identified WTC‐certified condition, were utilized. The risk of frailty was estimated using log binomial regression analysis. A 95% confidence interval (CI) was used to estimate the prevalence ratio (PR).ResultsOne hundred and six participants were included; 38 (35.8%) were classified as pre‐frail or frail. More of the pre‐frail/frail group were obese (57.9% vs. 25%; p = 0.004) and had a WTC‐certified condition (78.9% vs. 58.8%; p = 0.036). Obesity (PR = 2.43, 95% CI = 1.31, 4.53), a WTC‐certified condition (PR = 1.77, 95% CI = 1.09, 2.89), and risk of falling (PR = 1.97, 95% CI = 1.01, 3.84) were independently associated with frailty.ConclusionsObesity and having a WTC‐certified condition were found to be risk factors for frailty in our pilot study. Future work may focus on further identifying risk factors for frailty in the larger WTC general responder population.

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FRAIL Questionnaire Screening Tool and Short-Term Outcomes in Geriatric Fracture Patients

Cited by 123 publications

References 39 publications

Frailty and Delirium in Older Adults: A Systematic Review and Meta‐Analysis of the Literature

Frailty and Delirium in Older Adults: A Systematic Review and Meta‐Analysis of the Literature

Geriatrics in the 21st century

A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort

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