Fragmentation of the α-Amino Acid Methionine in Field Desorption Mass Spectrometry

Greef, J. van der; Nibbering, N. M. M.; Schulten, H.-R.; Lehmann, Wolf D.

doi:10.1515/znb-1978-0718

Zeitschrift Für Naturforschung B

1978

DOI: 10.1515/znb-1978-0718

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Fragmentation of the α-Amino Acid Methionine in Field Desorption Mass Spectrometry

J. van der Greef¹,

N. M. M. Nibbering²,

H.-R. Schulten³

et al.

Abstract: AbstractField Desorption Mass Spectrometry, a-Amino Acid Methionine The fragmentation of methionine in field desorption mass spectrometry has been studied. Decomposition mechanisms are described which are based on stable isotope labelling, low and high resolution field desorption, and the application of field desorption kinetics. The combined use of these techniques for the study of some fundamental fragmentations in field desorption is demonstrated successfully. Further, a com… Show more

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Cited by 4 publications

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Four decades of joy in mass spectrometry

Nibbering

2006

Mass Spectrometry Reviews

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Tremendous developments in mass spectrometry have taken place in the last 40 years. This holds for both the science and the instrumental revolutions in this field. In chemistry the research was heavily focused on organic molecules that upon electron ionization fragmented via complex mechanistic pathways as shown by isotopic labeling experiments. These studies, including ion structure determinations, were performed with use of double focusing mass spectrometers of both conventional and reversed geometry, and equipped with various types of metastable ion scanning and collision-induced dissociation techniques developed by physical and analytical chemists. Time-resolved mass spectrometry by use of the field ionization kinetics method, developed by physical chemists, was another powerful way to unravel details of unimolecular gas phase ion dissociations. Then the development of new ionization methods, such as desorption chemical ionization, field desorption, and fast atom bombardment permitted not only to analyze unvolatile, thermally labile and higher molecular weight compounds, but also to study their chemical behavior in the gas phase, initially with use of double focusing instruments and later on with multisector and hybrid mass spectrometers. These ionization methods also enabled to study organometallic compounds and increasingly the field of medium-sized to large biomolecules, the latter being exploded in the last decade by the development of electrospray- and matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. Another area of research concerned the bimolecular chemistry of organic ions with organic molecules in the gas phase. Initially this was performed with use of among others drift-cell ion cyclotron resonance spectroscopy, that later on was replaced by the developed method of ion trapping and Fourier transform ion cyclotron resonance. Combination of the latter with the afore-mentioned ionization methods has shifted also in this case the research on organic molecules to organometallic/inorganic systems, and predominantly to biomolecules in the last decade. This invited review will describe the research efforts made by the author's group over the last 40 years together with some personal experiences during his career.

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Four decades of joy in mass spectrometry

Nibbering

2006

Mass Spectrometry Reviews

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A fast atom bombardment study of methionine in combination with deuterium labelling

Greef

Brauw

Zwinselman

et al. 1982

Org. Mass Spectrom.

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The mechanism of ion formation from methionine under fast atom bombardment conditions shows similarities with those reported in secondary ion, laser desorption and field desorption mass spectrometry.Deuterium labelling has indicated that the mode of fragmentation of this compound upon fast atom bombardment closely resembles that observed under chemical ionization conditions using methane as reagent gas.

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Biochemical, medical, and environmental applications of field-ionization and field-desorption mass spectrometry

Schulten

1979

International Journal of Mass Spectrometry and Ion Physics

242

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Fragmentation of the α-Amino Acid Methionine in Field Desorption Mass Spectrometry

Cited by 4 publications

References 12 publications

Four decades of joy in mass spectrometry

Four decades of joy in mass spectrometry

A fast atom bombardment study of methionine in combination with deuterium labelling

Biochemical, medical, and environmental applications of field-ionization and field-desorption mass spectrometry

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