Fragment-Based Approach Identifies a Novel Inhibitory Site on DHPS

Abstract

extracellular domain (ECD) of CaSR with various spectroscopic methods including the tryptophan fluorescence titration, circular dichroism (CD) and nuclear magnetic resonance (NMR) as well as molecular dynamic simulation. These results provide important implications for our understanding of how the CaSR integrates information about these two completely different classes of agonists-an inorganic divalent cation, and another hand, a nutrient-how the receptor senses these agonists in healthy and diseased states.