Fractions of plasma gamma-glutamyltransferase in healthy individuals: Reference values

Abstract

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Dynamics of glutathione and ophthalmate traced with2H-enriched body water in rats and humans

“…enzyme ␥-glutamyltranspeptidase (11), which may contribute to accelerating isotopic equilibration as well as degradation of GSH.…”

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“…However, Huo et al (2011) studied the antioxidant and hepatoprotective effect of licorice aqueous extract against the oxidative damage induced by CCl 4 (3 mL kg -1 ) in rats and the results showed that all tested concentrations (100, 150 and 300 mg kg -1 ) effectively protected the liver of animals, and the protective effect of the extract was evidenced by a decrease in the levels of AST and ALT. Frazini et al (2008) and Teixeira et al (2009) reported that ALT is found primarily in the liver, and considered a more sensitive indicator than AST, since it exists in all body tissues, especially the heart, liver, skeletal muscle, kidneys, brain, pancreas, leukocytes, erythrocytes. GGT is a glycoprotein enzyme regularly attached to the cell membrane and participates in the transport of amino acids and peptides to cells and tissue glutathione levels.…”

New perspectives for use of gamma-glutamyltranspeptidase in clinical enzymes tests

“…Сывороточный фермент имеет множественные формы, выявленные с помощью высокоэффективной жидкостной хроматографии и, вероятно, связанные с посттрансляционной модификацией, которую определяют множественные сайты гликозилирова ния на поверхности белка [14].…”

“…3. Схема посттрансляционной модификации белков путем S глутатио нирования и S нитрозилирования [38] 10 атеросклероза, метаболического синдрома, сахар ного диабета 2 го типа, сердечно сосудистых забо леваний выявляются, когда значения активности фермента находятся в пределах верхнего квартиля референсных значений [14,22,26,27]. Из этого сле дует, что референсные интервалы должны быть определены с учетом возрастных, гендерных, нут риентных и других факторов в популяции.…”