Fractionation of phytocannabinoids from industrial hemp residues with high-pressure technologies

Vági, Erika; Balázs, Margit; Komóczi, Attila; Mihalovits, Máté; Székely, Edit

doi:10.1016/j.supflu.2020.104898

Cited by 15 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3. Comparing the best result with the one obtained from a previous study conducted by our SFE research group using the same plant material and carried out scCO 2 extraction with 10 w/w% of ethanol co-solvent (scCO 2 EtOH) [25], we found the following: in case of PLE with ethanol, the operation time and solvent mass consumption have been decreased 20 and 31-fold, respectively. However, by fast and efficient PLE extraction the maximum CBD yield was 5.1 g CBD/g dry material, significantly lower than in the case of the co-solvent assisted supercritical fluid extraction (6.98 g CBD/g dry material).…”

Section: Yield Curves and Regression Analysissupporting

confidence: 59%

“…The industrial hemp phenotype was previously the subject of another study of our research group (marked as Sample 5) [25]. It is a fiber-type variaty harvested in 2013 with a moisture content of 11.0 ± 0.1 (w/w%).…”

Section: Materials and Methods 21 Materialsmentioning

confidence: 99%

“…Interestingly, if the results of the scCO 2 -EtOH [25] were compared, at first, no similarity could be observed. However, when the consumed CO 2 was excluded from the feed ratio calculations and only the 10 w/w% EtOH was considered as a solvent, a unique phenomenon was observed as it can be seen on Fig.…”

Section: Concentration Profile Of Plementioning

confidence: 98%

“…However, in the practical application, the separation of solid fractions (e.g., inflorescences from leaves) is highly time-consuming and also unfavorable for the low-cost agricultural industry. In response, some recent studies focus on combined threshing residue extraction [4,[25][26][27][28], or stage-wise extraction of waste materials with respect to different fiber production units [8]. These separation processes are all based on solid-liquid or fluid extractions and mainly with batch operation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pressurized Liquid Extraction of Hemp Residue and Purification of the Extract with Liquid-Liquid Extraction

Béri

Nagy

Kovács

et al. 2021

Period. Polytech. Chem. Eng.

Self Cite

View full text Add to dashboard Cite

The first semi-continuous Pressurized Liquid Extraction (PLE) of hemp threshing residue with ethanol was carried out according to a 32 full factorial experimental design with pressure and temperature as independent variables at 8-10-12 MPa and 323-333-343 K, respectively. The total- and cannabidiol (CBD) yield curves were fitted to the modified two-parameter Brunner equation. Best results, concerning CBD, can be achieved at 12 MPa and 343 K. Solvent mass-consumption and operation time were considerably decreased compared to a previous supercritical fluid extraction study on the same material. Furthermore, the concentration profiles were evaluated to study the mass transfer. The winterized dry extracts were further studied in a methanol-hexane-water ternary system concerning CBD distribution ratio, showing high methanol dependency.

show abstract

Section: Yield Curves and Regression Analysissupporting

confidence: 59%

Section: Materials and Methods 21 Materialsmentioning

confidence: 99%

Section: Concentration Profile Of Plementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pressurized Liquid Extraction of Hemp Residue and Purification of the Extract with Liquid-Liquid Extraction

Béri

Nagy

Kovács

et al. 2021

Period. Polytech. Chem. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…25 Moreover, several extractions of cannabinoids from different parts of the cannabis plant, for instance, leaves, trimmings, buds, flowers and threshing residues, have been performed using ethanol as a co-solvent. [26][27][28][29] Within the past years, ionic liquids have also emerged as alternative reaction media for the extraction of biomass that is regarded as a source of natural medicinally relevant complex compounds. Many different properties are attributed to ionic liquids, such as exceptional dissolution properties, high thermal stability and broad liquid range, to name a few.…”

Section: Introductionmentioning

confidence: 99%

Combined ionic liquid and supercritical carbon dioxide based dynamic extraction of six cannabinoids from Cannabis sativa L.

et al. 2021

View full text Add to dashboard Cite

show abstract

Application of gas chromatography in the analysis of phytocannabinoids: An update (2020–2023)

Nahar,

Gavril,

Sarker

2023

Phytochemical Analysis

View full text Add to dashboard Cite

IntroductionCannabinoids are a group of compounds that bind to cannabinoid receptors. They possess pharmacological properties like that of the plant Cannabis sativa. Gas chromatography (GC) is one of the popular chromatographic techniques that has been routinely used in the analysis of cannabinoids in different matrices.ObjectiveThe article aims to review the literature on the application of GC‐based analytical methods for the analysis of phytocannabinoids published during the period from January 2020 to August 2023.MethodologyA thorough literature search was conducted using different databases, like Web of Knowledge, PubMed, Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were cannabinoids, Cannabis sativa, marijuana, analysis, GC, quantitative, qualitative, and quality control. From the search results, only the publications that incorporate the GC analysis of phytocannabinoids were reviewed, and papers on synthetic cannabinoids were excluded.ResultsSince the publication of the review article on GC analysis of phytocannabinoids in early 2020, several GC‐based methods for the analysis of phytocannabinoids have appeared in the literature. While simple 1D GC–mass spectrometry (MS) and GC–flame ionisation detector (FID) methods are still quite common in phytocannabinoids analysis, 2D GC‐MS and GC‐MS/MS are increasingly becoming popular, as these techniques offer more useful data for identification and quantification of phytocannabinoids in various matrices. The use of automation in sample preparation and the utilisation of mathematical and computational models for optimisation of different protocols have become a norm in phytocannabinoids analysis. Pre‐analyses have been found to incorporate different derivatisation techniques and environmentally friendly extraction protocols.ConclusionsGC‐based analysis of phytocannabinoids, especially using GC‐MS, remains one of the most preferred methods for the analysis of these compounds. New derivatisation methods, ionisation techniques, mathematical models, and computational approaches for method optimisation have been introduced.

show abstract

Fractionation of phytocannabinoids from industrial hemp residues with high-pressure technologies

Cited by 15 publications

References 15 publications

Pressurized Liquid Extraction of Hemp Residue and Purification of the Extract with Liquid-Liquid Extraction

Pressurized Liquid Extraction of Hemp Residue and Purification of the Extract with Liquid-Liquid Extraction

Combined ionic liquid and supercritical carbon dioxide based dynamic extraction of six cannabinoids from Cannabis sativa L.

Application of gas chromatography in the analysis of phytocannabinoids: An update (2020–2023)

Contact Info

Product

Resources

About