Fractionated Irradiation and Early Changes in Noradrenaline Induced Potassium Efflux (<sup>86</sup>Rb<sup>+</sup>) in Rat Parotid Gland

Franzén, Lars; Sundström, Staffan; Karlsson, Mikael; Gustafsson, H.; Littbrand, Bo; Henriksson, Roger

doi:10.3109/02841869209108186

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…In rats, Franzen et al (22) estimated the α/β ratio for early effects to be high, ≈20 Gy. The clinical Continuous hyperfractionated accelerated radiotherapy (CHART) experience has suggested that hyperfractionation has a protective effect on late function, consistent with a low α/β ratio (23).…”

Section: Mathematical Modelingmentioning

confidence: 99%

Radiotherapy Dose–Volume Effects on Salivary Gland Function

Deasy

Moiseenko

Marks

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

490

406

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Publications relating parotid dose-volume characteristics to radiotherapy-induced salivary toxicity were reviewed. Late salivary dysfunction has been correlated to the mean parotid gland dose, with recovery occurring with time. Severe xerostomia (defined as long-term salivary function of <25% of baseline) is usually avoided if at least one parotid gland is spared to a mean dose of less than ≈20 Gy or if both glands are spared to less than ≈25 Gy (mean dose). For complex, partial-volume RT patterns (e.g., intensity-modulated radiotherapy), each parotid mean dose should be kept as low as possible, consistent with the desired clinical target volume coverage. A lower parotid mean dose usually results in better function. Submandibular gland sparing also significantly decreases the risk of xerostomia. The currently available predictive models are imprecise, and additional study is required to identify more accurate models of xerostomia risk.

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Section: Mathematical Modelingmentioning

confidence: 99%

Radiotherapy Dose–Volume Effects on Salivary Gland Function

Deasy

Moiseenko

Marks

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

490

406

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“…Dose fractions ranged from 4-9 Gy administered daily for 5 days, and function was assessed at 10 and 180 days following irradiation. At total doses comparable to the 20 Gy employed by Bodner et al they reported norepinephrine stimulated potassium secretion (as measured by 86 Rb + efflux) to be unaffected. Potassium secretion was depressed in a dose-dependent manner at the higher doses employed in these studies.…”

Section: In Vivo Versus In Vitro Responsementioning

confidence: 80%

“…(85)(86)(87) who studied the early and late in vitro cellular responses of rat parotid acinar cells following in vivo fractionated irradiation. Dose fractions ranged from 4-9 Gy administered daily for 5 days, and function was assessed at 10 and 180 days following irradiation.…”

Section: In Vivu Versus In Vitru Responsementioning

confidence: 99%

Preemptive Pharmacologic Intervention in Radiation-Induced Salivary Dysfunction

Taylor

Miller

1999

Experimental Biology and Medicine

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Xerostomia (“dry mouth”) is a symptom of several diseases. It also occurs as a side effect of certain therapeutic interventions, most frequently pharmacotherapy. The most severe and irreversible forms of salivary dysfunction result from damage to or loss of salivary acinar cells. One of the severest forms of iatrogenic salivary gland destruction results from the therapeutic doses of irradiation given to treat head and neck cancer or to purge the bone marrow before transplantation. Xerostomia encompasses a wide range of involvement, from an inconvenience when mild, to a debilitating condition when severe. Reports of the symptom of dry mouth by patients do not always correlate with the degree of diminished salivary flow. However, a significant loss of stimulated flow makes it difficult to process solid food into a bolus that can be swallowed. If sustained, nutritional deficiencies may result. Saliva also facilitates formation of speech patterns. Its loss hinders speaking and communicating, possibly causing the patient to withdraw from social interaction. Together these conditions can impair the physiological and psychological well-being of the patient Thousands of individuals undergo radiation therapy for head and neck cancer in the United States each year. Increasing numbers are receiving total body radiation before transplantation of bone marrow. Although the salivary gland is not one of the more actively dividing organs in the body, nevertheless it ranks as one of the most radiosensitive. The mechanism of this sensitivity is not understood. This article reviews human and animal pathophysiology of radiation-induced salivary damage. We also discuss animal studies that have employed various strategies to modify and clarify this process. Finally, we describe encouraging results from early clinical trials suggesting that protection of salivary glands during therapeutic irradiation may be possible.

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“…The / ratio for parotid has been estimated to be close to 20 in rats. 13 Contrary to this it is believed from the continuous hyperfractionated accelerated radiotherapy…”

Section: Fractionationmentioning

confidence: 95%

Radiation-Induced Xerostomia

Agarwal¹,

Baijal²,

Kar³

2012

International Journal of Head and Neck Surgery

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Xerostomia is a common complication following radiotherapy for head and neck cancers. This has long-term implications on the quality of life of these patients. The better understanding of salivary function and the interaction of radiotherapy dose-volume and fractionation with salivary function has allowed us to intervene with various modalities to prevent or treat this common complication. Thus we present a review of published literature describing the factors affecting xerostomia, its prevention and treatment.

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Fractionated Irradiation and Early Changes in Noradrenaline Induced Potassium Efflux (⁸⁶Rb⁺) in Rat Parotid Gland

Cited by 11 publications

References 25 publications

Radiotherapy Dose–Volume Effects on Salivary Gland Function

Radiotherapy Dose–Volume Effects on Salivary Gland Function

Preemptive Pharmacologic Intervention in Radiation-Induced Salivary Dysfunction

Radiation-Induced Xerostomia

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Fractionated Irradiation and Early Changes in Noradrenaline Induced Potassium Efflux (86Rb+) in Rat Parotid Gland

Cited by 11 publications

References 25 publications

Radiotherapy Dose–Volume Effects on Salivary Gland Function

Radiotherapy Dose–Volume Effects on Salivary Gland Function

Preemptive Pharmacologic Intervention in Radiation-Induced Salivary Dysfunction

Radiation-Induced Xerostomia

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Product

Resources

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Fractionated Irradiation and Early Changes in Noradrenaline Induced Potassium Efflux (⁸⁶Rb⁺) in Rat Parotid Gland