Fractional sodium excretion and its relation to in-hospital morbidity and mortality in patients admitted with decompensated heart failure

Thabt, Sameh Saleh; Enany, Basem; Soliman, Karim roshudy

doi:10.1016/j.ehj.2013.01.001

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…These affordable products may enhance patient compliance and persistence, and prescribers may be influenced by such practical considerations. Furthermore, a high incidence of diuretic resistance has been reported among Egyptian patients, and adjunct medications such as thiazide diuretic metolazone are not commonly included in the hospital formularies [6,36]. The inaccessibility of adjunct diuretics such as metolazone may also have contributed to the unexpectedly high rate of prescription of two or more loop diuretics.…”

Section: Discussionmentioning

confidence: 99%

Heart Failure Prescribing Quality at Discharge from a Critical Care Unit in Egypt: The Impact of Multidisciplinary Care

et al. 2020

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Discharge prescriptions for heart failure (HF) patients may not adhere to the clinical practice guidelines. This study aimed to assess the impact of the clinical pharmacist as a member of a multidisciplinary team on the quality of prescribing to HF patients at discharge from a Critical Care Unit (CCU) in Egypt. This was a retrospective cohort study of HF patients discharged from the CCU between January 2013 and December 2017. Guideline Adherence Index (GAI-3) was used to assess guideline-directed prescribing at discharge. Multidisciplinary care was introduced to the CCU on 1 January 2016. The study included 284 HF patients, mean (±SD) age 66.7 ± 11.5 years, 53.2% male. Heart failure with reduced ejection fraction affected 100 patients (35.2%). At discharge, loop diuretics were prescribed to 85.2% of patients; mineralocorticoid receptor antagonists to 54.9%; angiotensin-converting enzyme inhibitors/angiotensin receptor blockers to 51.4%; and β-blockers to 29.9%. Population Guideline Adherence Index (GAI-3) was 45.5%. High-GAI was prescribed to 136 patients (47.9%). Patients with High-GAI were younger; less affected by chronic kidney disease and had fewer comorbidities than those without High-GAI. Prescription of β-blocker increased (24.1% vs. 38.6%, p < 0.001) and digoxin utilization decreased (34.7% vs. 23.7%, p < 0.049) after the introduction of the multidisciplinary care. The inclusion of a clinical pharmacist in the multidisciplinary care team may have a role in optimizing the prescribing of HF guideline-directed therapies at discharge from this setting.

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Section: Discussionmentioning

confidence: 99%

Heart Failure Prescribing Quality at Discharge from a Critical Care Unit in Egypt: The Impact of Multidisciplinary Care

et al. 2020

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“…Heart failure (HF) is one of the most common causes of hospital admission and readmission in patients over 65 years of age. It is a clinical syndrome resulting from structural and functional cardiac disorders that impair the heart's ability to fill with (diastolic) and/or to eject (systolic) blood commensurate with the metabolic needs of the body 1‐3 . A common precursor and contributor to HF is cardiac hypertrophy, a pathological condition that sets in as the heart attempts to compensate for its poor ability to circulate the blood.…”

Section: Introductionmentioning

confidence: 99%

ICS II protects against cardiac hypertrophy by regulating metabolic remodelling, not by inhibiting autophagy

Han

Wang

Cui

et al. 2020

J Cellular Molecular Medi

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Heart failure (HF) is one of the most common causes of hospital admission and readmission in patients over 65 years of age. It is a clinical syndrome resulting from structural and functional cardiac disorders that impair the heart's ability to fill with (diastolic) and/or to eject (systolic) blood commensurate with the metabolic needs of the body. 1-3 A common precursor and contributor to HF is cardiac hypertrophy, a pathological condition that sets in as the heart attempts to compensate for its poor ability to circulate the blood. Cardiac hypertrophy is characterized by an increase in the size of individual cardiomyocytes, rather than their overall numbers, in order to temporarily maintain the cardiac output. 4 Long-term hypertrophy eventually leads to ischaemia, arrhythmia, heart failure and sudden death. 5 However, the precise pathophysiological mechanisms that explain the transition from hypertrophy to clinical HF are not well understood. 6

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Fractional sodium excretion and its relation to in-hospital morbidity and mortality in patients admitted with decompensated heart failure

Cited by 2 publications

References 17 publications

Heart Failure Prescribing Quality at Discharge from a Critical Care Unit in Egypt: The Impact of Multidisciplinary Care

Heart Failure Prescribing Quality at Discharge from a Critical Care Unit in Egypt: The Impact of Multidisciplinary Care

ICS II protects against cardiac hypertrophy by regulating metabolic remodelling, not by inhibiting autophagy

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