Fractional-order rat bite fever model: a mathematical investigation into the transmission dynamics

Khirsariya, Sagar R.; Yeolekar, Mahesh A.; Yeolekar, Bijal M.; Chauhan, Jignesh P.

doi:10.1007/s12190-024-02116-1

J. Appl. Math. Comput.

2024

DOI: 10.1007/s12190-024-02116-1

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Fractional-order rat bite fever model: a mathematical investigation into the transmission dynamics

Sagar R. Khirsariya,

Mahesh A. Yeolekar,

Bijal M. Yeolekar

et al.

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2024

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Cited by 1 publication

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Global Analysis of a Fractional‐Order Hepatitis B Virus Model Under Immune Response in the Presence of Cytokines

Naik,

Yeolekar,

Qureshi

et al. 2024

Advcd Theory and Sims

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This research proposes and investigates an epidemiological model to study the dynamic behaviors of the Hepatitis B virus (HBV) under immune response and cytokine influence. The model's stability, positivity, boundedness, and equilibria are analyzed using Lyapunov functional methods and the Routh–Hurwitz criterion under Caputo fractional derivative. The study evaluates nucleoside analogues and interferon treatments, determining critical drug efficiencies. Equilibria, including infection‐free and endemic states, are analyzed using the fundamental reproduction number, , to predict disease elimination. Numerical simulations utilize the fractional Adams method and the L1 scheme, capturing memory traces as the fractional order changes. Results show the L1 scheme effectively captures memory traces, providing empirical support for the theoretical findings. Furthermore, Ulam–Hyers stability is treated according to the equilibrium point, which describes relationships between functions. Notably, the findings of the study yielded profound insights. They revealed that the HBV system remains locally asymptotic stable at disease‐free and the endemic point when . At the same time, the simulations illustrated a correlation between the rate of infection and the rise in infected individuals, indicating the feasibility of eradicating and effectively managing HBV infections through a multifaceted approach and various measures such as vaccination and effective drug administration protocols. The proposed framework can guide medical professionals and decision‐makers in developing effective strategies to limit and eliminate the spread of HBV in the population.

show abstract

Global Analysis of a Fractional‐Order Hepatitis B Virus Model Under Immune Response in the Presence of Cytokines

Naik,

Yeolekar,

Qureshi

et al. 2024

Advcd Theory and Sims

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Fractional-order rat bite fever model: a mathematical investigation into the transmission dynamics

Cited by 1 publication

References 26 publications

Global Analysis of a Fractional‐Order Hepatitis B Virus Model Under Immune Response in the Presence of Cytokines

Global Analysis of a Fractional‐Order Hepatitis B Virus Model Under Immune Response in the Presence of Cytokines

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