Fractional adjustment of predicted creatinine clearance in females

Once‐Daily Cefepime Versus Ceftriaxone for Nursing Home–Acquired Pneumonia

“…To ensure a study population of patients with a ClCr less than 60 mL/min, only patients aged 60 and older were eligible. Simple calculation of estimated ClCr 22,23 reveals that, for patients aged 60 and older, men with a serum creatinine of 1.1 mg/dL or greater and women with a serum creatinine of 1 mg/dL or greater will have an estimated ClCr 60 mL/min or less (Table 5). This study provides clinical evidence that the dosing recommendation is appropriate.…”

“…Inclusion criteria were a new infiltrate on chest roentgenogram compatible with the diagnosis of pneumonia, estimated ClCr of 60 mL/min or less, and presence of at least one of the following major criteria (cough, hyperthermia (>38°C), hypothermia (<36°C), or purulent sputum) or two of the following minor criteria (dyspnea, pleuritic chest pain, altered mental status, signs of pulmonary consolidation on physical examination, or white blood cell count (WBC) >12,000 neutrophils/mm 3 ). ClCr was estimated initially from serum creatinine values 22,23 obtained within 6 months of enrollment.…”

Establishment of creatinine clearance reference values for older women

“…This formula was developed from data for 249 men, ages 18-90 years, and a 15% reduction in the resulting creatinine clearance for women was proposed based on data from the literature (21). Validation of this correction factor for women has been limited and inconclusive (20,(22)(23)(24)(25)(26).…”