Establishment of creatinine clearance reference values for older women

Abstract

Age-adjusted reference ranges for creatinine clearance were determined in 279 women, ages 40-95 years, who were housed in a metabolic research unit and consumed a meat-free diet. Creatinine clearance, but not serum creatinine, declined with age by 0.63 mL/min per 1.73 m2 per year. Serum and urine creatinine concentrations, used to calculate clearances, were analyzed by a kinetic Jaffé procedure. In a subset of 100 subjects, fasting serum creatinine values averaged 8.3 +/- 5.2 (SD) mumol/L higher when measured by the kinetic Jaffé procedure than by an enzymatic method (creatinine PAP). The Cockcroft-Gault formula for estimating creatinine clearance from serum creatinine in women was validated, and the modification factor for the male equation was determined to be 0.84 (95% confidence interval 0.83-0.86) confirming the suggested 15% correction. A prediction formula derived from this population was similar in accuracy to the Cockcroft-Gault formula.

The Role of Diet- and Host-Related Factors in Nutrient Bioavailability and Thus in Nutrient-Based Dietary Requirement Estimates

“…decreased clearance from the circulation occurs with other fat-soluble substances with advancing age is not clear. Renal function is also known to decline with advancing age [166], which could influence the bioavailability of those nutrients (or nutrient metabolites) which are excreted mainly via the kidney (e.g., selenium, iodine, chromium) and for which renal conservation plays a key role in homeostasis.…”

Use of a Urine Color Chart to Monitor Hydration Status in Nursing Home Residents

“…Renal function, as measured by serum creatinine levels and creatinine clearance, is known to decline with age in men (Lindeman, Tobin, & Shock, 1985;Rowe, Andres, Tobin, Norris, & Shock, 1976). Few longitudinal studies have been conducted that include older women; however, recent reports indicate that creatinine clearance also decreases in both healthy and frail elderly women (Papaionnou et al, 2001;Sokoll, Russell, Sadowski, & Morrow, 1994). Serum creatinine levels rise in both sexes with increasing age, although men's levels are higher than women's at all ages (Papaionnou et al, 2001).…”

Serum Creatinine Is an Inadequate Screening Test for Renal Failure in Elderly Patients

“…13 This formula has been validated in elderly populations to accurately predict the measured creatinine clearance and the glomerular filtration rate. [14][15][16] The C-G GFR has also been superior to measured creatinine clearance as a predictor of glomerular filtration rate in several studies. [17][18][19] Renal failure was defined as a C-G GFR of 50 mL/min or less.…”