2000
DOI: 10.4049/jimmunol.164.8.4055
|View full text |Cite
|
Sign up to set email alerts
|

Fractalkine-Mediated Endothelial Cell Injury by NK Cells

Abstract: Endothelial cells (ECs) are primary targets of immunological attack, and their injury can lead to vasculopathy and organ dysfunction in vascular leak syndrome and in rejection of allografts or xenografts. A newly identified CX3C-chemokine, fractalkine, expressed on activated ECs plays an important role in leukocyte adhesion and migration. In this study we examined the functional roles of fractalkine on NK cell activity and NK cell-mediated endothelial cell injury. Freshly separated NK cells expressed the fract… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

5
123
0
1

Year Published

2002
2002
2018
2018

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 178 publications
(129 citation statements)
references
References 53 publications
(54 reference statements)
5
123
0
1
Order By: Relevance
“…The membraneanchored form of FKN can be cleaved from the cell membrane by proteolysis to yield s-FKN (18,20,21). The resulting shedded FKN contains the chemokine domain and the mucin-like stalk domain and, conversely to the membrane form of FKN, behaves as a potent chemoattractant for almost all NK cells (65), T lymphocytes (18,22,66), and dendritic cells (24,67). Migration of monocytes in response to s-FKN is still under debate.…”
Section: Discussionmentioning
confidence: 99%
“…The membraneanchored form of FKN can be cleaved from the cell membrane by proteolysis to yield s-FKN (18,20,21). The resulting shedded FKN contains the chemokine domain and the mucin-like stalk domain and, conversely to the membrane form of FKN, behaves as a potent chemoattractant for almost all NK cells (65), T lymphocytes (18,22,66), and dendritic cells (24,67). Migration of monocytes in response to s-FKN is still under debate.…”
Section: Discussionmentioning
confidence: 99%
“…The membrane-bound FKN is able to mediate firm adhesion of CX 3 CR1-expressing leukocytes without requiring selectin-mediated rolling or activation of integrins 18,19 . Furthermore, FKN is released from the cell surface by proteolytic cleavage as soluble FKN (sFKN) that has potent chemoattractant activity for CX 3 CR1 + leukocytes and activates them 12,17,20 …”
Section: Introductionmentioning
confidence: 99%
“…It is a unique chemokine since it is located on a membrane bound mucin stalk and is in transmembrane and soluble shed forms [26]. Fractalkine has adhesive properties, promoting leukocyte migration and enhancing the cytotoxicity of NK cells [27] and cytotoxic T-lymphocytes [28]. Fractalkine has an important role in cardiac allograft rejection [29,30], and it is expressed in mononuclear cells during renal inflammation [31].…”
mentioning
confidence: 99%