Fractalkine is an epithelial and endothelial cell derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa

Muehlhoefer, Andreas; Saubermann, Lawerence J.; Gu, Xuibin; Lüedtke-Heckenkamp, Kerstin; Xavier, Ramnik J.; Blumberg, Richard S.; Podolsky, Daniel K.; MacDermott, Richard P.

doi:10.1016/s0016-5085(00)82524-x

Cited by 40 publications

(48 citation statements)

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“…An upregulation of fractalkine expression in primary cultures of human umbilical vein and pulmonary artery endothelium or in epithelial cells by IFN-γ, IL-1, or TNF-α has been previously described. 12,31,32 Interestingly, Fujimoto et al 33 reported high levels of fractalkine in the BAL fluid of patients with inflammatory diseases, such as idiopathic pulmonary fibrosis or sarcoidosis, as well as a correlation between bronchoalveolar mononuclear cell counts and bronchoalveolar fractalkine concentrations. In addition, they showed that fractalkine expression and fractalkine-mediated adhesion of mononuclear cells are increased in bronchial epithelial cells from patients with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

The CX3C chemokine fractalkine in allergic asthma and rhinitis

Rimaniol

Till

Garcia

et al. 2003

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

The CX3C chemokine fractalkine in allergic asthma and rhinitis

Rimaniol

Till

Garcia

et al. 2003

Journal of Allergy and Clinical Immunology

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“…The chemokine CX3CL1/fractalkine, which signals through CX3CR1, is also expressed by IEC and by endothelial cells in normal SI, and is upregulated in active CD mucosa [27]. The fractalkine receptor, CX3CR1, is expressed on a subset of CD8 + IELs, natural killer (NK) cells, and the proinflammatory CD16 + monocytes, which migrate toward fractalkine in vitro [28].…”

Section: Homeostatic or Constitutive Chemokine Expression In The Intementioning

confidence: 99%

Chemokines in inflammatory bowel disease

Papadakis

2004

Curr Allergy Asthma Rep

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Ulcerative colitis (UC) and Crohn's disease (CD), collectively termed inflammatory bowel diseases (IBD), represent chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract that are characterized by leukocytic infiltration of the intestinal mucosa and submucosa. In CD, the inflammation is transmural and frequently associated with granuloma formation. Chemokines have emerged as the most important regulators of leukocyte trafficking during infection or inflammation and, therefore, have been implicated in the pathogenesis of IBD. In this review, recent advances on the role of chemokines and their receptors in mucosal immunity and inflammation are discussed, and the potential use of chemokine/chemokine-receptor antagonists as novel therapeutic targets for the treatment of human IBD is highlighted.

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“…These cells produce inflammatory mediators. Several inflammatory mediators enhance the fractalkine mRNA levels and the production of fractalkine [15,19]. The production of fractalkine in the endometrium might be regulated by autocrine and paracrine mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Amplification using CX 3 CR1-specific primers yielded a 653-bp DNA product and amplification using the fractalkine-specific primers yielded a 597-bp DNA product [15]. Molecular sizes were estimated using a 100-bp DNA ladder (TOYOBO, Osaka, Japan).…”

Section: Rt-pcr Amplificationmentioning

confidence: 99%