“…The surfaces of gold (Au), silver (Ag), or copper (Cu) nanostructures can exhibit an effective SERS signal. − Usually, Ag nanostructures have an excellent physical and chemical property in comparison with other precious metals, which have been widely studied and applied in the fields of optical sensors, biological diagnosis, catalysis, microelectronics, and so on . In addition, owing to the high SERS performance of Ag nanostructures, many meaningful results have been reported in the field of SERS-based biosensors. − At present, many types of Ag nanostructures have also been synthesized, such as nanorods, NPs, , nanonets, nanowires, , nanosheets, etc. Especially, a Ag nanosheet nanostructure has a large surface area for easily adsorbing some biomolecules, which is considered as an ideal material for the SERS detection.…”