FPTT is a low‐incidence Rh antigen associated with a “new” partial Rh D phenotype, DFR

Lomas, C; Grässmann, W; Ford, D. S.; Watt, Julie M.; Gooch, Ann; Jones, Joquina Chiquita M; Beolet, Marylise; Stern, Daniel; Wallace, Mary; Tippett, Patricia

doi:10.1046/j.1537-2995.1994.34794330017.x

Cited by 47 publications

(25 citation statements)

References 9 publications

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“…50). 52), and is still used to name new variants. Some D categories were also found to express one or more lowfrequency Rh antigens, for example the BARC (RH52) antigen on DVI RBCs (reviewed by Ref.…”

Section: Rhd Variant Phenotypesmentioning

confidence: 99%

Molecular biology of Rh proteins and relevance to molecular medicine

Avent

Madgett

Lee

et al. 2006

ERM

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The Rhesus (Rh) blood group system is expressed by a pair of 12-transmembrane-domain-containing proteins, the RhCcEe and RhD proteins. RhCcEe and RhD associate as a Rh core complex that comprises one RhD/CcEe protein and most likely two Rh-associated glycoproteins (RhAG) as a trimer. All these Rh proteins are homologous and share this homology with two human non-erythroid proteins, RhBG and RhCG. All Rh protein superfamily members share homology and function in a similar manner to the Mep/Amt ammonium transporters, which are highly conserved in bacteria, plants and invertebrates. Significant advances have been made in our understanding of the structure and function of Rh proteins, as well as in the clinical management of Rh haemolytic disease. This review summarises our current knowledge concerning the molecular biology of Rh proteins and their role in transfusion and pregnancy incompatibility.

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Section: Rhd Variant Phenotypesmentioning

confidence: 99%

Molecular biology of Rh proteins and relevance to molecular medicine

Avent

Madgett

Lee

et al. 2006

ERM

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“…[187] gave the name DFR to a new partial D antigen, identifi ed with the assistance of monoclonal antibodies. [187] gave the name DFR to a new partial D antigen, identifi ed with the assistance of monoclonal antibodies.…”

Section: Partial D and The Epitopes Of Dmentioning

confidence: 99%

“…Red cells with the DFR phenotype react with an antibody to the low frequency Rh antigen FPTT [187,188] . In 23 propositi DFR was associated with RHCE * Ce and in two propositi with RHCE * cE .…”

Section: Dfr and The Fptt ( Rh50) Antigenmentioning

confidence: 99%

Rh and RHAG Blood Group Systems

Daniels

2013

Human Blood Groups

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“…commun.]. The low-incidence antigen Tar (Rh40) is associated with DMI [3] and FPTT (Rh50) with [8], Monoclonal antibodies (Mabs) have been used to identify nine different D epitopes, epDl-epD9 [9,10]. D…”

Section: Introductionmentioning

confidence: 99%

Identification of Two New D Variants, D^HMi and D^HMii Using Monoclonal Anti-D

Jones¹

1995

Vox Sanguinis

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Fifteen examples of red cells are described which showed discrepant reactivity on routine grouping with two monoclonal anti-D typing reagents, HAM-A being negative and MAD-2 strongly positive. The reaction profile of these cells with a number of monoclonal anti-D characterised the samples into two new variant groups, D^HM1 and D^HM11. D^HM1 was characterised by a negative reaction with BRAD-8 and D^HM11 by a negative reaction with BRAD-5. D^HM1 cells were found to have a papain-sensitive site, identified by Mab 21 G6, which was not detectable in D^HMii. The presence of allo-anti-D in one case of D^HMi suggests a partial D in these individuals. The positive reaction of HAM-A with sialidase- and endo-F-treated D^HMii cells suggests that sialic acid and/or N-glycans could possibly be involved in blocking the reaction with untreated cells. All samples typed as C-E+. One was e negative while the rest had variable depression of the e and f antigens. Marginal depression of E was seen with those D^HMi cells tested, but not with D^HMii cells. Data from family studies suggest that the variant D in both DHMi and D^HMii is inherited as a cDE gene complex and is controlled by the RH locus.

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FPTT is a low‐incidence Rh antigen associated with a “new” partial Rh D phenotype, DFR

Abstract: The partial D of the Rh D phenotype, DFR, is recognized by its pattern of reactions with monoclonal anti-D and its association with the low-incidence antigen FPTT, FPTT has now been numbered Rh50.

Cited by 47 publications

References 9 publications

Molecular biology of Rh proteins and relevance to molecular medicine

Molecular biology of Rh proteins and relevance to molecular medicine

Rh and RHAG Blood Group Systems

Identification of Two New D Variants, D^HMi and D^HMii Using Monoclonal Anti-D

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