Foxp1 gene expression in projection neurons of the mouse striatum

Tamura, Shinobu; Morikawa, Yoshihiro; Iwanishi, Hiroki; Hisaoka, Tomoko; Senba, Emiko

doi:10.1016/j.neuroscience.2003.11.036

Cited by 85 publications

(76 citation statements)

References 29 publications

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“…For instance, such cells may be generated, but are not fully differentiated and/or die in the damaged striatum. The transcription factors COUP TF1-interacting protein 2 (Ctip2) and forkhead box P1 (Foxp1) are expressed by young and mature striatal medium-sized spiny projection neurons but not striatal interneurons (Tamura et al, 2004;Arlotta et al, 2008). The LIM-homeobox factor Islet1 is expressed by striatal cholinergic interneurons (Elshatory and Gan, 2008).…”

Section: The Vast Majority Of Newborn Neurons In the Damaged Striatummentioning

confidence: 99%

Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

Liu¹,

You²,

Li³

et al. 2009

J. Neurosci.

103

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Neuroblasts produced by the neural stem cells of the adult subventricular zone (SVZ) migrate into damaged brain areas after stroke or other brain injuries, and previous data have suggested that they generate regionally appropriate new neurons. To classify the types of neurons produced subsequent to ischemic injury, we combined BrdU or virus labeling with multiple neuronal markers to characterize new cells at different times after the induction of stroke. We show that SVZ neuroblasts give rise almost exclusively to calretininexpressing cells in the damaged striatum, resulting in the accumulation of these cells during long term recovery after stroke. The vast majority of SVZ neuroblasts as well as newly born young and mature neurons in the damaged striatum constitutively express the transcription factor Sp8, but do not express transcription factors characteristic of medium-sized spiny neurons, the primary striatal projection neurons lost after stroke. Our results suggest that adult neuroblasts do not alter their intrinsic differentiation potential after brain injury.

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Section: The Vast Majority Of Newborn Neurons In the Damaged Striatummentioning

confidence: 99%

Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

Liu¹,

You²,

Li³

et al. 2009

J. Neurosci.

103

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show abstract

“…The FOXP1 and FOXP2 genes encode transcription factors important for brain development; however, these genes are also expressed in the adult brain [51][52][53]. Although the exact function of FOXP1 is unclear, FOXP2 contributes to plasticity and neurite outgrowth during development [54,55].…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact function of FOXP1 is unclear, FOXP2 contributes to plasticity and neurite outgrowth during development [54,55]. Foxp1 and Foxp2 are expressed in subsets of neurons in various CNS regions [36,37,51]. In mouse cerebral cortex, for example, Foxp1 is expressed in neocortical neurons from layers III to VIa, whereas Foxp2 is expressed in Darpp-32-positive projection neurons from layer VI [37].…”

Section: Discussionmentioning

confidence: 99%

“…In mouse cerebral cortex, for example, Foxp1 is expressed in neocortical neurons from layers III to VIa, whereas Foxp2 is expressed in Darpp-32-positive projection neurons from layer VI [37]. In mouse striatum, ∼65% of Map2-positive neurons and 72% of Darpp-32-positive neurons express Foxp1 [51]. Because interneurons are Foxp1 negative, Foxp1 expression appears to be restricted to projection neurons [51].…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Differentiation of Human Neural Progenitor Cells Into Striatal GABAergic Neurons

Lin

Yuan

Sander

et al. 2015

Stem Cells Translational Medicine

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Huntington's disease (HD) results from a CAG repeat expansion in the gene encoding the huntingtin protein. This inherited disorder is characterized by progressive neurodegeneration. In particular, HD progression involves the loss of striatal projection neurons. The limited availability of reliable sources of human striatal projection neurons currently hampers our understanding of HD mechanisms and hinders the development of novel HD treatments. In this paper, we described two-and three-step methods for differentiating human neural progenitor cells toward striatal projection neurons. In the two-step differentiation protocol, 90%, 54%, and 6% of MAP2-positive cells were immunopositive for GABA, calbindin (CALB1), and DARPP-32/PPP1R1B, respectively. In the three-step differentiation protocol, 96%, 84%, and 21% of MAP2-positive cells were immunopositive for GABA, calbindin, and DARPP-32/PPP1R1B, respectively. In line with a striatal projection neuron phenotype, cells differentiated with our protocols displayed significantly increased expression of MAP2, CALB1, DARPP-32/PPP1R1B, ARPP21, and CTIP2. Application of glutamate receptor agonists induced calcium influx; accordingly, the cells also expressed various ionotropic glutamate receptor subunits. Differentiated cells also released GABA on stimulation. We suggest that our three-step differentiation protocol presents a reliable and simplified method for the generation of striatal projection neurons, yielding a critical resource for neuronal physiology and neurodegenerative disorder studies. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:775-788 SIGNIFICANCEThe earliest changes in the neurodegenerative disorder Huntington's disease affect a specific type of brain neurons, the so-called medium spiny neurons of the striatum. In this study, two protocols were developed for the differentiation of neural progenitor cells into striatal medium spiny neurons, and the differentiated neurons were extensively characterized. The data indicate that the three-step differentiation protocol presents a reliable and simplified method for the generation of striatal medium spiny neurons. The generated striatal medium spiny neurons could represent a critical resource for the study of neurodegenerative disorders, a model system for drug discovery, and a step toward cellbased regeneration therapies.

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“…Ventral LGE generate GABAergic projection neurons that also express Isl1 during early specification, followed by the expression of other striatal-specific TF such as FoxP1, FoxP2, and Ctip2 [93][94][95]. Later in development, dLGE generates interneurons that migrate to the olfactory bulbs [13;95].…”

Section: Neuronal Specificationmentioning

confidence: 99%

Telencephalic Neurogenesis Versus Telencephalic Differentiation of Pluripotent Stem Cells

Nat¹,

Apostolova²,

Dechant³

2013

Trends in Cell Signaling Pathways in Neuronal Fate Decision

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Foxp1 gene expression in projection neurons of the mouse striatum

Cited by 85 publications

References 29 publications

Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

In Vitro Differentiation of Human Neural Progenitor Cells Into Striatal GABAergic Neurons

Telencephalic Neurogenesis Versus Telencephalic Differentiation of Pluripotent Stem Cells

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