FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue

Turrel-Davin, Fanny; Tournadre, Anne; Pachot, Alexandre; Arnaud, Béatrice; Cazalis, Marie-Angélique; Mougin, Bruno; Miossec, Pierre

doi:10.1136/ard.2009.109991

Cited by 43 publications

(37 citation statements)

References 37 publications

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“…Akt-mediated phosphorylation of FoxO family members occurs in the cytoplasm and interferes with the binding of FoxO to target genes involved in cell cycle arrest (36). FoxO3a is highly expressed and phosphorylated in synovial tissues from RA patients (37). Thus, we examined whether or not PLD1 is involved in the regulation of FoxO3a.…”

Section: Resultsmentioning

confidence: 99%

Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a

Kang

Park

et al. 2013

Molecular and Cellular Biology

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Section: Resultsmentioning

confidence: 99%

Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a

Kang

Park

et al. 2013

Molecular and Cellular Biology

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“…1 Expression of Amh, Bmp15, and Gdf9 mRNA in a GHRKO (black bar) and normal mice (white bar), b normal mice treated with PMA (black bar) or DMSO (white bar), and c GHRKO mice treated with PMA (black bar) and DMSO (white bar) Glabowska et al 2012). Studies in other tissues generally indicate that higher FOXO3 mRNA expression predicts also higher level of nuclear FOXO3 (Essaghir et al 2009;Turrel-Davin et al 2010). Despite that, it is known that cellular localization (nuclear vs. cytoplasmic) of FOXO3 rather than the level of expression truly indicates the activation of this protein.…”

Section: Discussionmentioning

confidence: 99%

Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries

Schneider

Zhi

Bartke

et al. 2014

AGE

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The activation of the Pi3k-Akt1-FOXO pathway seems to be involved in the extended longevity observed in growth hormone receptor/growth hormone binding protein knockout (GHRKO) mice and is related to the growth of primordial ovarian follicles. The aim of this work was to measure the expression of genes in the ovaries of GHRKO and normal (N) mice treated with phorbol 12-myristate 13-acetate (PMA), an inhibitor of GH and IRS1 signaling. For this study, a group of N (n= 10) and GHRKO (n=10) mice, N mice treated (n=10) or not (n=10) with PMA, and GHRKO mice treated (n= 10) or not (n=10) with PMA were used. All were 6-month-old female mice. After the last PMA injection, the ovaries were collected for gene expression analysis. Expression of Amh, Gdf9, and Bmp15 was higher in GHRKO than N mice (P<0.05), but was not different between PMA-treated N mice (P>0.10). Expression of Amh and Gdf9 was higher (P<0.05) for GHRKO PMAtreated mice. In addition, we observed a higher expression of Socs3 (P<0.001) in GHRKO than N mice and a tendency for increased expression of Foxo3a (P=0.07). For GHRKO PMA-treated mice, Foxo3a mRNA expression was higher (P=0.02) and a tendency for higher expression of Mtor (P=0.06) and Socs3 (P=0.10) in GHRKO PMA-treated mice was observed. To summarize, the present data further confirm the previous histological observations that GHRKO mice have an ovarian phenotype characteristic of younger mice indicated by higher expression of Amh, Gdf9, and Bmp15 mRNA. In addition, we have shown a higher expression of Socs3 in GHRKO mice and higher Foxo3a expression in PMAtreated GHRKO mice, suggesting a role for these mediators in the process of ovarian aging.

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“…Moreover, blockade of FasL made Foxo-3a-deficient mice arthritic. In addition, both the phosphorylated and un-phosphorylated forms of Foxo-3a proteins were detected in RA synovium [89]. Thus, targeting Foxo-3a may prove to be beneficial in overcoming Fas/FasL-deficient apoptosis of neutrophils in RA inflamed synovium.…”

Section: Fas (Cd95)/fas Ligand (Cd178)mentioning

confidence: 99%

Apoptosis Resistance in Rheumatoid Arthritis Synovial Tissue

Malemud¹

2012

J Clin Cell Immunol

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FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue

Cited by 43 publications

References 37 publications

Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a

Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a

Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries

Apoptosis Resistance in Rheumatoid Arthritis Synovial Tissue

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