FoxO1 enhances differentiation and apoptosis in human primary keratinocytes

Shi, Ge; Liao, Peiyu; Cai, Xiao-Lin; Pi, Xiao-Xue; Zhang, Man-Feng; Li, Shijie; Quan, Juan-Hua; Fan, Yi‐Ming

doi:10.1111/exd.13775

Cited by 32 publications

(19 citation statements)

References 38 publications

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“…Shi et al 35 provide evidences that FoxO1 may be involved in acne pathogenesis promoting differentiation and apoptosis in human primary keratinocytes while isotretinoin can reinforce FoxO1 expression.…”

Section: Discussionmentioning

confidence: 99%

Do acne treatments affect insulin‐like growth factor‐1 serum levels? A clinical and laboratory study on patients with acne vulgaris

Rodighiero

Bertolani

Saleri

et al. 2020

Dermatologic Therapy

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Acne is a chronic inflammatory disease affecting sebaceous gland follicles. Lately, acne has considered an insulin‐like growth factor‐1 (IGF‐1) mediated disease. Recent research demonstrated that IGF‐1 levels decrease after 3 months of isotretinoin. The purpose of our study is evaluating the influence of acne treatments on IGF‐1 serum levels. Forty‐six subjects with acne vulgaris aged 14 to 30 years were subdivided into three groups according to their severity of acne and treated following the European Dermatology Forum guidelines. IGF‐1 was measured in patients before and after the treatment and then compared to the IGF‐1 of a healthy population of the same age. IGF‐1 resulted higher in patients than in controls but there was not a statistically significant variation after treatment. To the best of our knowledge, this is the first study evaluating the influence of topical and systemic acne treatment on IGF‐1 serum levels. In contrast with the literature, our results suggest that common therapies for acne are not able to significantly modify IGF‐1 serum levels.

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Section: Discussionmentioning

confidence: 99%

Do acne treatments affect insulin‐like growth factor‐1 serum levels? A clinical and laboratory study on patients with acne vulgaris

Rodighiero

Bertolani

Saleri

et al. 2020

Dermatologic Therapy

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“…Its teratogenicity is also regarded as an apoptotic effect of this retinoid on neural crest cells. It is expressed that isotretinoin enhances the expression of p53 and FoxO1 and FoxO3, all apoptosis-promoting transcription factors [8–11].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

Açmaz

Çınar

Acmaz

et al. 2019

BioMed Research International

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Introduction. Many patients who were diagnosed as polycystic ovary syndrome- (PCOS-) related acne were not capable of sustaining or beginning oral contraceptive pills (OCPs) due to pill scaring, contraindications of OCP use, migraine, or smoking. In this situation, oral isotretinoin treatment may become an important option for PCOS-related acne. The aim of the study was to determine the effects of isotretinoin treatment on PCOS patients who were complicated with severe cystic acne. Materials and Methods. This study consisted of 40 female patients diagnosed as PCOS complicated with severe cystic acne. These patients were not eligible candidates for OCP use due to migraine, thrombophilia, heavy smoking, or pill scare. To establish baseline values of hormone levels, on days 2–5 of the menstrual cycle, venous blood samples were obtained. Moreover Modified Ferriman-Gallwey (mFG) score, acne score (AS), follicle count, and bilateral ovarian volumes were evaluated both before and after isotretinoin treatment. Results. Isotretinoin treatment significantly decreased Ferriman-Gallwey score, free testosterone, insulin level, hemoglobin level, acne score, and ovarian volume. Increased triglyceride and cholesterol levels were detected after treatment. Conclusion. Isotretinoin treatment may have beneficial effects on free testosterone, insulin, acne score, and Ferriman-Gallwey score. Solely isotretinoin administration may supply adequate healing in PCOS patients’ symptoms complicated with severe cystic acne who is not eligible candidates for OCP use. This trial is registered with Clinicaltrials.gov NCT02855138.

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“…В настоящем исследовании при изучении интактной кожи при сепсисе мы установили изменения пролиферации и апоптоза кератиноцитов, такие как снижение метаболического состояния, гипопролиферация и изменение дифференцировки. Поддержание гомеостаза кожи требует тонко-го баланса между пролиферацией, дифференцировкой и апоптозом [5]. Для изучения клеточной пролиферации использовали маркер Ki-67.…”

Section: Discussionunclassified

Immunophenotypic Characteristic of Proliferation and Apoptosis of Intact Keratinocytes in Sepsis

Shapovalova¹,

Demyashkin

Malanichrev³

et al. 2020

Crimea Journal of Experimental and Clinical Medicine

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In response to infection by pathogenic microbes, a serious systemic inflammation occurs in the body, often lead- ing to death. Unbalanced systemic immune responses can lead to the accumulation of leukocytes, disseminated intravascular coagulation and microcirculatory dysfunction, followed by apoptosis and cell necrosis, as well as the development of multiple organ failure syndrome. The destruction of the barrier can apparently lead to a violation of the proliferation and apoptosis of keratinocytes. The aim of the study was to evaluate intracellular protein-regulators of the life cycle of keratinocytes of the intact epidermis in case of systemic inflammation. Material and methods. The study was performed on 40 archival paraffin blocks of skin fragments in two groups: group I (n = 30) - deceased patients with a diagnosis of severe bacterial sepsis; Group II (n = 10) – dead for reasons not related to an infectious disease (control). Immunohistochemical studies were performed according to a standard protocol using antibodies to Ki-67, caspase 3, Bcl-2 and p53. Results. In the cells of the epidermis of patients in the condition of systemic inflammation, the following expression of the studied markers is observed: caspase-3 – 39.4 ± 1.2%; p53 – 18.4 ± 0.7%; Ki-67 – 15.2 ± 4.1%; Bcl-2 – 4.2 ± 1.2%. Conclusion Under conditions of systemic inflammation in the epidermis, there is an imbalance in the proliferative- apoptotic activity of keratinocytes in the direction of reducing their mitotic division and activation of apoptosis, leading to cell death.

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FoxO1 enhances differentiation and apoptosis in human primary keratinocytes

Cited by 32 publications

References 38 publications

Do acne treatments affect insulin‐like growth factor‐1 serum levels? A clinical and laboratory study on patients with acne vulgaris

Do acne treatments affect insulin‐like growth factor‐1 serum levels? A clinical and laboratory study on patients with acne vulgaris

The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

Immunophenotypic Characteristic of Proliferation and Apoptosis of Intact Keratinocytes in Sepsis

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