Fox Fordyce disease as a secondary effect of laser hair removal

Abstract

Fox Fordyce disease (FFD) has been recently described as an adverse effect of laser hair removal. It is an apocrine gland disorder characterized by pruritus and a folliculocentric papular eruption in apocrine sweat gland areas. Different etiologies have been proposed to be the cause of this entity. It has been suggested that a fisical factor could contribute to FFD phatogenesis. We report a new case of FFD after laser hair removal.

Fox–Fordyce Disease: An under‐diagnosed adverse event of laser hair removal?

“…Mast cells were absent in all reported cases as well as in our patients (Table ). Xanthomatous inflammation is considered to be the final step in the pathogenesis of classic FFD when the body attempts to collect the lipid‐laden apocrine secretions in the cytoplasm of reactive histiocytes . The two reported cases were considered to be a variant of FFD since foam cells were absent.…”

“…Fox–Fordyce Disease (FFD) is a rare chronic inflammatory skin disease of the apocrine glands, mainly affecting post‐pubertal women . It involves apocrine gland‐bearing areas including the axilla, areola, anogenital area and umbilicus . It is characterized by multiple, skin‐coloured to yellowish, perifollicular, usually pruritic, uniform papular skin lesions with associated hypotrichosis and hyperkeratosis .…”

“…There are a lot of controversies concerning its pathogenesis which remains unknown. Fox–Fordyce disease has been reported to occur after completing a series of axillary hair removal . The pathogenesis of laser hair removal‐induced FFD is still unknown.…”

“…1 It involves apocrine gland-bearing areas including the axilla, areola, anogenital area and umbilicus. [1][2][3][4][5] It is characterized by multiple, skin-coloured to yellowish, perifollicular, usually pruritic, uniform papular skin lesions with associated hypotrichosis and hyperkeratosis. [2][3][4][5] There are a lot of controversies concerning its pathogenesis which remains unknown.…”

“…Fox-Fordyce disease has been reported to occur after completing a series of axillary hair removal. [2][3][4][5] The pathogenesis of laser hair removal-induced FFD is still unknown.…”