Foveal Cone Outer Segment Tips Line and Disruption Artifacts in Spectral-Domain Optical Coherence Tomographic Images of Normal Eyes

Rii, Tosho; Itoh, Yuji; Inoue, Makoto; Hirakata, Akito

doi:10.1016/j.ajo.2011.08.021

Cited by 40 publications

(27 citation statements)

References 24 publications

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“…We were not able to measure the thickness of foveal OS because these high-density pixels could be artifacts. 29 Figures 2C and 2D also show that an isopter (V-4-e) exists in the foveal region before and after the treatment with QLT091001. This supports the existence of surviving photoreceptors in the fovea that are not measurable by our SD-OCT segmentation technique.…”

Section: Discussionmentioning

confidence: 89%

Outer Segment Thickness Predicts Visual Field Response to QLT091001 in Patients withRPE65orLRATMutations

Wen

Birch

2015

Trans. Vis. Sci. Tech.

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Purpose: To determine whether the degree of change in Goldmann visual fields (GVFs) following oral administration of QLT091001 was related to baseline measures of retinal structure.Methods: Oral QLT091001 was administered once daily for 7 days in all study patients. Comprehensive ophthalmic testing, including spectral-domain optical coherence tomography (SD-OCT), was conducted in 14 patients with Leber congenital amaurosis (LCA) and 18 patients with retinitis pigmentosa (RP) at seven international sites. Average thickness of the outer segment (OS) layer was calculated over central 208. Both eyes of each subject were evaluated separately.Results: Nineteen of 28 eyes (68%) with LCA and 13 of 36 eyes (36%) with RP responded to QLT091001. Among these responders, the average baseline thickness of the OS layer (central 208) was 13.5 lm in the LCA cohort and 11.7 lm in the RP cohort. Nonresponders had average baseline OS thickness of less than 4.6 lm in both cohorts. The OS thickness in the central 208 was significantly shorter in nonresponders than responders in the LCA cohort (P ¼ 0.01, t-test) and in the RP cohort (P ¼ 0.02, Wilcoxon rank sum test). The OS thickness in the central 208 did not change significantly from baseline during the first 2 months (P ¼ 0.09, t-test, paired). Conclusions:The present findings suggest that there is a close parallel between the thickness of the photoreceptor layer and the potential for functional improvement in these patients.

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Section: Discussionmentioning

confidence: 89%

Outer Segment Thickness Predicts Visual Field Response to QLT091001 in Patients withRPE65orLRATMutations

Wen

Birch

2015

Trans. Vis. Sci. Tech.

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“…We first evaluated the normal fellow eyes of 29 of the 45 patients studied ( 18 Two representative cases demonstrating how the OCT features were judged to be either normal or abnormal are shown in Figure 1B and C. A horizontal SD-OCT scan image of the left retina of a 74-year-old man is shown in Figure 1B. The ELM, foveal bulge, IS/OS junction line, and COST line were clearly observed and judged to be normal.…”

Section: Resultsmentioning

confidence: 99%

Outer Retinal Morphology and Visual Function in Patients With Idiopathic Epiretinal Membrane

Watanabe¹,

Tsunoda²,

Mizuno³

et al. 2013

JAMA Ophthalmol

101

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To determine the relationship between the morphology of the fovea and visual acuity in patients with an untreated idiopathic epiretinal membrane (ERM). Methods:We examined 52 eyes of 45 patients diagnosed with an ERM. The morphology of the foveal area was determined by spectral-domain optical coherence tomography. The relationships between the best-corrected visual acuity (BCVA) and 8 optical coherence tomography features, central retinal thickness, cone outer segment tip (COST) line, photoreceptor inner/outer segment (IS/OS) junction line, foveal bulge of the IS/OS line, external limiting membrane, inner limiting membrane, foveal pit, and ERM over the foveal center, were evaluated.Results: Multiple regression analysis showed that intact COST line, IS/OS junction line, and external limiting membrane independently and significantly contrib-uted to the BCVA. The standardized partial regression coefficient ␤ was 0.415 for the COST line, 0.287 for the IS/OS junction line, and 0.247 for the external limiting membrane. However, the other features, eg, foveal bulge, inner limiting membrane, foveal pit, and ERM, were not significantly associated with the BCVA. The central retinal thickness was significantly correlated with the BCVA (r 2 =0.274; P Ͻ.01).Conclusions: At an early stage of an ERM, only the photoreceptor structures are significantly associated with the BCVA, and the appearance of the COST line was most highly associated. Detailed examinations of the photoreceptor structures using optical coherence tomography may help find photoreceptor dysfunction in cases of idiopathic ERM.

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“…In a recent report, intact foveal interdigitation zones were detected in only 95% of normal healthy individuals. 16 In the current study, interdigitation zone disruption was found in 20% of the unaffected eyes. Given that more than 20% of AMD patients have bilateral lesions, 17,18 our finding suggests that the OCT may have detected predisease changes that were not detected by either fundus examination or angiographies in the fellow eyes.…”

Section: Discussionmentioning

confidence: 87%

Functional Visual Acuity in Age-Related Macular Degeneration

2016

Optometry and Vision Science

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Purpose. We evaluated whether a functional visual acuity (FVA) system can detect subtle changes in central visual acuity that reflect pathological findings associated with age-related macular degeneration (AMD). Methods. Twenty-eight patients with unilateral AMD and logMAR monocular best corrected VA better than 0 in both eyes, as measured by conventional chart examination, were analyzed between November 2012 and April 2013. After measuring conventional VA, FVA, and contrast VA with best correction, routine eye examinations including spectral domainYoptical coherence tomography were performed. Standard Schirmer test was performed, and corneal and lens densities were measured. Results. The FVA score (p G 0.001) and visual maintenance ratio (p G 0.001) measured by the FVA system, contrast VA (p G 0. 01), and conventional VA (p G 0.01) were significantly worse in the AMD-affected eyes than in the fellow eyes. No significant differences were observed in the anterior segment conditions. Forward stepwise regression analysis demonstrated that the length of interdigitation zone disruption, as visualized by optical coherence tomography imaging, correlated with the FVA score (p G 0.01) but not with any other parameters investigated. Conclusions. The FVA system detects subtle changes in best corrected VA in AMD-affected eyes and reflects interdigitation zone disruption, an anatomical change in the retina recorded by optical coherence tomography. Further studies are required to understand the value of the FVA system in detecting subtle changes in AMD. (Optom Vis Sci 2016;93:70Y76) Key Words: functional visual acuity, interdigitation zone, optical coherence tomography, age-related macular degeneration, retina R ecent progress in medical technology and science has facilitated the development of effective treatments for retinal diseases, such as molecular targeted drugs, and antiYvascular endothelial growth factor (anti-VEGF) drugs for age-related macular degeneration (AMD), as well as pars plana vitrectomy. With the improvement in prognosis, treatment is extended to patients who have better visual function at baseline. Thus, a sensitive method for detecting subtle changes in central visual acuity (VA) that reflects pathological findings of AMD and other retinal diseases is warranted. One method proposed for this purpose is the functional VA (FVA) system. The FVA system can detect subtle visual dysfunction caused by epiretinal membrane in eyes with good VA as measured by conventional Landolt C charts.1 However, whether this method is able to detect the subtle impairment of visual function caused by AMD and reflect the retinal clinical findings remains obscure.The FVA system uses a series of charts shown continuously and requires patient responses within 2 s of each chart display, which is in contrast to the conventional Landolt C chart examination, in which patients can stare at the chart before responding. Contrast VA testing involves the use of a lower-contrast Landolt C chart than conventional VA measurement, but...

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Foveal Cone Outer Segment Tips Line and Disruption Artifacts in Spectral-Domain Optical Coherence Tomographic Images of Normal Eyes

Cited by 40 publications

References 24 publications

Outer Segment Thickness Predicts Visual Field Response to QLT091001 in Patients withRPE65orLRATMutations

Outer Segment Thickness Predicts Visual Field Response to QLT091001 in Patients withRPE65orLRATMutations

Outer Retinal Morphology and Visual Function in Patients With Idiopathic Epiretinal Membrane

Functional Visual Acuity in Age-Related Macular Degeneration

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