Outer Retinal Morphology and Visual Function in Patients With Idiopathic Epiretinal Membrane

Watanabe, Kenji; Tsunoda, Kazushige; Mizuno, Yoshinobu; Akiyama, Kunihiko; Noda, Tomoyuki

doi:10.1001/jamaophthalmol.2013.686

Cited by 101 publications

(80 citation statements)

References 24 publications

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“…Previous studies reported good surgical outcomes and many prognostic factors, such as preoperative visual acuity, retinal thickness, photoreceptor layer status, and the status of other specific layers of the retina, for the outcome following ERM surgery [13,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32]. Among these, preoperative vision is a well-known prognostic factor that influences postoperative vision.…”

Section: Discussionmentioning

confidence: 99%

Changes in Visual Acuity after Idiopathic Epiretinal Membrane Removal: Good versus Poor Preoperative Visual Acuity

Byon

Jo²,

Kwon³

et al. 2015

Ophthalmologica

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Purpose: To investigate postoperative visual acuity changes following idiopathic epiretinal membrane (ERM) surgery as well as investigate the relationship between outcome and baseline visual acuity. Methods: The medical records of 159 consecutive eyes were retrospectively reviewed for best corrected visual acuity (BCVA), central subfield macular thickness (CSMT), and the ellipsoid zone (EZ) signal of the photoreceptor layer at baseline and 1, 3, and 6 months after surgery. Patients were divided into two groups: group A, with good vision of 20/50 or better, and group B, with poor visual acuity worse than 20/50. Results: Seventy-nine eyes were included in group A and 80 eyes in group B. Mean baseline BCVA was 0.28 and 0.65 logarithm of the minimum angle of resolution (logMAR), and the mean baseline CSMT was 423.7 and 505.6 μm in group A and group B, respectively. In group A, BCVA worsened to 0.39 logMAR at 1 month (p < 0.001) and gradually improved to 0.25 logMAR at 6 months, which was not different from baseline BCVA. In group B, BCVA and CSMT improved at 1, 3, and 6 months (p < 0.05). The EZ signal improved in group B (p = 0.003) but not in group A. The area under the receiver operating characteristic curve for the improvement in BCVA of ≥2 lines was significant for preoperative BCVA (0.717, 95% confidence interval 0.638-0.797; p < 0.001). The cutoff value was 0.35 on the logMAR scale. Conclusion: After ERM surgery, patients with good vision maintained visual acuity after temporary worsening of vision, and patients with poor vision achieved significant BCVA improvement.

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Section: Discussionmentioning

confidence: 99%

Changes in Visual Acuity after Idiopathic Epiretinal Membrane Removal: Good versus Poor Preoperative Visual Acuity

Byon

Jo²,

Kwon³

et al. 2015

Ophthalmologica

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“…Photoreceptors appear to be very sensitive to ERMinduced stresses and damage easily [2,3,16] . We also report early worsening in postoperative PROS length and both IS/OS and COST line disruptions, possibly due to peeling.…”

Section: Discussionmentioning

confidence: 99%

“…progressive, but some patients may report visual loss, metamorphopsia and narrowing of binocular vision as the membrane induces tractions with macular wrinkling and thickening [2][3][4] .…”

mentioning

confidence: 99%

Long-Term Anatomical and Functional Outcomes after Combined Cataract and Idiopathic Epiretinal Membrane Surgery

Kauffmann¹,

Ramel²,

Isaico³

et al. 2016

Ophthalmic Res

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Purpose: To describe the 2-year functional and anatomical outcomes in patients operated on for combined cataract and idiopathic epiretinal membrane (ERM) and to study the relationship between best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) throughout the follow-up. Methods: This retrospective observational case series included 72 eyes operated on for combined cataract and idiopathic ERM. They were followed with clinical and SD-OCT examinations preoperatively and 1, 6, 12, and 24 months after surgery. Foveolar thickness (FT), photoreceptor status and morphological parameters were assessed. Results: BCVA and FT substantially improved at 24 months. Postoperatively, no significant improvement was observed beyond 6 months for BCVA and 12 months for FT. Outer limiting membrane and inner and outer segment junction disruption scores were well correlated with BCVA both pre- and postoperatively, and significant visual improvement was demonstrated in each subgroup except in those with the highest scores. FT was correlated with BCVA only from 6 to 24 months postoperatively. Conclusion: After combined cataract and idiopathic ERM surgery, BCVA and FT improved rapidly. Most functional and anatomical recovery took place within the first 6 months, but this did not preclude late improvement, in particular in patients with the most disorganized photoreceptor layers. At each time point, the amount of photoreceptor damage seemed closely correlated with visual acuity, but concerning FT, this relationship remains questionable.

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“…Previous investigations studying VMT and ERM separately have observed a correlation between them, and the structural abnormalities in the EZ were associated with poor visual function [14,17,27,28,29]. The traction induced by VMT and/or ERM causes a loss of apposition, an elongation of the photoreceptor outer disks and an accumulation of subfoveal material [30].…”

Section: Discussionmentioning

confidence: 99%

Anatomical and Functional Changes in the Coexistence of Vitreomacular Traction and Epiretinal Membrane: A Spectral-Domain Optical Coherence Tomography Study

Chatziralli

Theodossiadis²,

Datseris³

et al. 2016

Ophthalmic Res

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Purpose: The purpose of this study was to evaluate the anatomical and functional findings in patients with vitreomacular traction (VMT) combined with epiretinal membrane (ERM) in the same eye. Methods: In this retrospective, cross-sectional study, we studied 65 patients with VMT and ERM. In 36 of them, ERM/VMT had a ‘unified' appearance (group Ι) but in 29, VMT and ERM coexisted without an interrelationship (group ΙΙ). All patients were examined with spectral-domain optical coherence tomography (SD-OCT). We recorded the macular thickness, the presence, type and location of macular edema, the horizontal diameter of VMT, ellipsoid zone/external limiting membrane (EZ/ELM) status, the vitreofoveal angle of VMT nasally and temporally and the best corrected visual acuity (BCVA). Results: Group Ι presented with increased macular thickness, a broader adhesion diameter, extensive EZ/ELM defect and decreased BCVA compared to those where VMT and ERM were not intercorrelated. In group I (‘unified' VMT and ERM), cystoid macular edema was found at a greater percentage (41.7%), while in patients where the 2 entities were not intercorrelated, diffuse macular edema was more evident (69%). There was no statistically significant difference between the 2 groups in the vitreofoveal angle temporally and nasally. Conclusions: Macular thickness, type of macular edema, adhesion diameter, the extent of the EZ/ELM defect and BCVA appeared different in cases where VMT and ERM were unified compared to cases where ERM and VMT coexisted but were not intercorrelated.

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Outer Retinal Morphology and Visual Function in Patients With Idiopathic Epiretinal Membrane

Cited by 101 publications

References 24 publications

Changes in Visual Acuity after Idiopathic Epiretinal Membrane Removal: Good versus Poor Preoperative Visual Acuity

Changes in Visual Acuity after Idiopathic Epiretinal Membrane Removal: Good versus Poor Preoperative Visual Acuity

Long-Term Anatomical and Functional Outcomes after Combined Cataract and Idiopathic Epiretinal Membrane Surgery

Anatomical and Functional Changes in the Coexistence of Vitreomacular Traction and Epiretinal Membrane: A Spectral-Domain Optical Coherence Tomography Study

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