Fourier Transform Infrared (FTIR) Spectroscopy to Analyse Human Blood over the Last 20 Years: A Review towards Lab-on-a-Chip Devices

Fadlelmoula, Ahmed; Pinho, Diana; Carvalho, Vı́tor; Catarino, Susana Oliveira; Minas, Graça

doi:10.3390/mi13020187

Cited by 71 publications

(28 citation statements)

References 57 publications

(93 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, for decades, infrared-based systems have offered a quantitative and qualitative analysis of biological samples for various applications (27,(39)(40)(41)(42)(43)(44)(45). For our purposes, this infrared-based approach provided evidence of the effective removal of appreciable levels of residual detergent and cellular/tissue debris, via the absence of spectral peaks in the frequency range 2849 cm -1 to 3075 cm -1 (46) in the elute collected on the 2 nd and 3 rd day during the washout process (FIGURE 2c).…”

Section: Discussionmentioning

confidence: 99%

A scalable corneal xenograft platform: simultaneous opportunities for tissue engineering and circular economic sustainability by repurposing slaughterhouse waste

Wang¹,

Shakeel²,

Salih³

et al. 2023

Preprint

View full text Add to dashboard Cite

High-throughput platforms that can generate copious quantities of corneal grafts will be invaluable in addressing the existing global demand for keratoplasty. Slaughterhouses generate substantial underutilized biological waste that can be repurposed to reduce current environmentally unfriendly practices. Such efforts to support ecological sustainability can simultaneously drive the development of transplantable ovine corneas and patient-specific bioartificial keratoprostheses. This study presents a dataset highlighting techniques that pioneered the development of a simplified, inexpensive, and high-throughput corneal xenograft platform. To the best of our knowledge, this is the first dataset to be generated in the United Arab Emirates devised on repurposing slaughterhouse waste in a manner that supports circular economic practices. These efforts outline the first step in developing a platform that can produce dozens of native ovine xenografts and acellular corneal scaffolds that effectively preserve ocular transparency, transmittance, and ECM components, and can be used to potentially create individualized and transplantable grafts. Such native grafts can then be genetically modified to reduce rejection and retrovirus transmission in recipients. Analogously, decellularization technologies can support corneal regeneration with key attributes comparable to native xenografts.

show abstract

Section: Discussionmentioning

confidence: 99%

A scalable corneal xenograft platform: simultaneous opportunities for tissue engineering and circular economic sustainability by repurposing slaughterhouse waste

Wang¹,

Shakeel²,

Salih³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Although there are studies investigating the use of FTIR for cancer diagnosis [ 16 , 57 , 58 , 59 , 60 , 61 , 62 ], this was not the objective of the present study. Here we pioneered combining infrared spectrum analyzes and levels of redox status markers in the blood, expanding the frontier of scientific knowledge in this area for women with HER2+ BC, HER2− BC, and BBD.…”

Section: Discussionmentioning

confidence: 99%

A Lower Serum Antioxidant Capacity as a Distinctive Feature for Women with HER2+ Breast Cancer: A Preliminary Study

Santos

Silva

Ferreira

et al. 2022

Cancers

View full text Add to dashboard Cite

The overexpression of HER2 in breast cancer (BC) can contribute to redox imbalance, which is related to damage and structural modification in many biomolecules. To the best of our knowledge, this is the first study that has investigated the infrared spectrum wavenumbers obtained by ATR-FTIR and their relationship with the levels of redox status markers such as reduced glutathione, superoxide dismutase (SOD), catalase, Ferric Reducing Antioxidant Power (FRAP), and protein carbonyl among women with HER2+ BC, HER2− BC, and benign breast disease (BBD). The study was conducted with 25 women, 17 of whom were diagnosed with BC (6 HER2+ and 11 HER2−) and 8 with BBD. Our results indicate HER2+ BC cases could be distinguished from HER2− BC and BBD cases by their serum’s antioxidant capacity [HER2+ BC vs. HER2− BC (AUC = 0.818; specificity = 81.82%; sensitivity = 66.67%); HER2+ BC vs. BBD (AUC = 0.875; specificity = 75%; sensitivity = 83.33%)]. The changes in biochemical terms that occur in serum as a result of the scarcity of antioxidants are related to a peculiar fingerprint in the infrared spectrum obtained by ATR-FTIR. In the serum of women with BBD, the SOD enzyme level is the highest, and this characteristic allowed us to distinguish them from HER2− BC. Finally, data regarding the serological antioxidant capacity of FRAP and the infrared spectrum by ATR-FTIR will allow us to assess biochemical changes that occur before clinical signs, indicating whether changes in therapy or interventions are necessary.

show abstract

“…FTIR analysis method uses infrared light to scan test samples and observe chemical property. FTIR is used to analyses functional groups in the nano composite (Fadlelmoula et al, 2022).…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Biosynthesis of Iron Oxide Nanoparticles and Using it to Support the Efficiency of Wastewater Filtration System

Al-Allaf¹,

Al-Rawi²,

AL-Ahmadi³

2023

RJS

View full text Add to dashboard Cite

Nanoparticles biosynthesis has gained great importance as an active eco-friendly method with economic benefit which overcame on other chemical and physical methods.This research involved green biosynthesis of iron oxide nanoparticles (IONPs) using Escherichia coli (E.coli) isolated from wastewater in Mosul city. Characterization of nanoparticles was performed by using many techniques which included UV-Vis Spectroscopy, Scanning Electron Microscope (SEM), Atomic Force Microscope (AFM), X-Ray Diffraction (XRD) and Fourier Transforms Spectroscopy (FTIR).Designing of a locally lab scale wastewater treatment plant was done by using IONPs adding to a dual water purification system, after tightly wrapping the filter with (1%) of IONPs solution up to saturation. Moreover, control filter was used. Sample of wastewater was passed through these filters to detect its effect on wastewater quality, the results showed that NPs filters improved physical, chemical and biological properties of wastewater including total plate count, coliform, fecal coliform and total fungi.

show abstract

Fourier Transform Infrared (FTIR) Spectroscopy to Analyse Human Blood over the Last 20 Years: A Review towards Lab-on-a-Chip Devices

Cited by 71 publications

References 57 publications

A scalable corneal xenograft platform: simultaneous opportunities for tissue engineering and circular economic sustainability by repurposing slaughterhouse waste

A scalable corneal xenograft platform: simultaneous opportunities for tissue engineering and circular economic sustainability by repurposing slaughterhouse waste

A Lower Serum Antioxidant Capacity as a Distinctive Feature for Women with HER2+ Breast Cancer: A Preliminary Study

Biosynthesis of Iron Oxide Nanoparticles and Using it to Support the Efficiency of Wastewater Filtration System

Contact Info

Product

Resources

About