Four Years of Observation to Evaluate Autonomy and Quality of Life after Implantation of a High-Add Intraocular Lens in Age-Related Macular Degeneration Patients

Borkenstein, Andreas F; Borkenstein, Eva-Maria

doi:10.1159/000508914

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Borkenstein and Borkenstein 28 reported a study of 11 Austrian patients with GA who underwent magnifying cataract surgery using a foldable, bifocal high-add intraocular lens (IOL) in the better-seeing eye. When completing a questionnaire listing 10 routine activities (reading, recognizing photos, eating and cooking, operating a telephone, daily hygiene rituals, brushing teeth, cutting nails, operating household appliances, manual work, and use of low-vision aids [eg, magnifying glasses]) at 6 months postsurgery, 10 of 11 patients reported limitations in their ability to complete these activities.…”

Section: Resultsmentioning

confidence: 99%

Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review

Sarda¹,

Heyes²,

Bektas³

et al. 2021

OPTH

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Purpose: Geographic atrophy (GA), the advanced form of dry age-related macular degeneration, can result in irreversible blindness over time. We performed a systematic literature review to assess the humanistic and economic burden of GA. Methods: Predefined search terms were used to identify studies in PubMed, Embase, and Cochrane Library; conference abstracts also were searched. Results: Of 1111 unique studies identified, 25 studies on humanistic burden, 4 on economic burden, and 3 on both humanistic and economic burden of GA were included. Vision-related functioning and health-related quality of life (HRQOL) are poor in patients with GA. HRQOL is commonly measured using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25); patients with GA have significantly lower composite and subscale scores for near activities, distance activities, dependency, driving, social functioning, mental health, role difficulties, color vision, and peripheral vision than individuals without GA. Driving is a particular concern, and inability to drive affects dependency. Vision-related quality of life (VRQOL) declines as GA progresses. While we identified only 7 reports describing the economic burden of GA, its direct costs may be substantial. In a US study, mean cost to the payer per patient with GA was $11,533 in the year after diagnosis. A multinational study estimated annualized total direct costs of €1772 per patient with GA, mainly driven by diagnostic tests and procedures (€1071). Patients with GA are at increased risk of falls and fractures, potentially increasing direct costs. Only one study evaluated indirect costs, estimating ~$24.4 billion in yearly lost wages among people with severe vision loss due to GA or drusen ≥125 μm. Conclusion: GA represents a significant humanistic burden. Evidence on the economic impact of GA is limited; characterizing the economic burden of GA requires further research. Interventions that reduce GA-related disability may improve HRQOL and reduce indirect costs.

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Section: Resultsmentioning

confidence: 99%

Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review

Sarda¹,

Heyes²,

Bektas³

et al. 2021

OPTH

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“…Cataract surgery with implantation of the LS-313 MF80 performed in one eye with simultaneous intravitreal injection of an anti-vascular endothelial growth factor agent improved CDVA and DCNVA [ 18 ]. In a subsequent study by the same authors, 4-years observational outcomes of 11 patients treated with this implant were reported [ 21 ]. The authors found an increase in CDVA and UNVA in all cases and 10/11 patients reported an improved quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…The authors claimed that this IOL offers safe and durable functional and quality of life benefits. They stated that additional clinical research would be needed to collect more outcome data to determine the clinical value of this implant [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

High-addition segmented refractive bifocal intraocular lens in inactive age-related macular degeneration: A multicenter pilot study

et al. 2021

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This multicenter, open-label study aimed to determine the safety and functional outcome of a high-addition segmented refractive bifocal intraocular lens (IOL) in late inactive age-related macular degeneration (AMD). Twenty eyes of 20 patients were enrolled and followed until 12 months after the intervention. Patients underwent cataract surgery with implantation of a LS-313 MF80 segmented refractive bifocal intraocular lens with a near addition of +8.0 D (Teleon Surgical Vertriebs GmbH, Berlin, Germany). The main outcome measures were distance corrected near visual acuity (DCNVA) and safety as determined by intra- and post-operative complications. Secondary outcomes included distance corrected visual acuity (CDVA), uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), the need for magnification to read newspaper, preferred reading distance, speed and performance (logRAD), as well as patient satisfaction. Mean DCNVA improved from 0.95 (±0.19) to 0.74 (±0.35) logMAR, until 6 months after surgery, P<0.05. CDVA improved from 0.70 (±0.23) to 0.59 (±0.30) logMAR, UDVA from 0.94 (±0.25) to 0.69 (±0.34) logMAR, UNVA from 1.08 (±0.19) to 0.87 (±0.43) logMAR. The mean need for magnification decreased from 2.9- to 2.3-fold, preferred reading distance from 23 to 20 cm. No intraoperative complications occurred during any of the surgeries. One patient lost > 2 lines of CDVA between 6 and 12 months, in another case, the study IOL was exchanged for a monofocal one due to dysphotopsia and decreased CDVA. Implantation of a segmented refractive bifocal IOL with +8.0 D addition improves near and distance vision in patients with late AMD and has a satisfactory safety profile.

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“…ИОЛ LENTIS® MAX LS-313 MF80 представляет собой модификацию вращательного асимметричного рефракционного бифокального LENTIS® Mplus LS-313 MF 30 (Oculentis, Германия), который включает в себя ближний сегмент на передней поверхности, но также и эквивалентный ближний сегмент на задней стороне, чтобы обеспечить прибавку +8,0 D (+6,0 D в очковой плоскости). Бифокальные свойства LENTIS® MAX LS-313 MF 80 обеспечивают хорошее зрение вдаль и увеличение примерно в 2,5 раза вблизи, что может свести к минимуму необходимость увеличения ближнего поля для пациентов с развитой ВМД [38]. В литературе данные о клинической эффективности и безопасности LENTIS® MAX LS-313 MF 80 являются единичными.…”

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Features of Phacosurgery in Macular Pathology. Part 2. Сapabilities of Optical Correction

Юсеф¹,

Воробьева²,

Казарян³

et al. 2021

Oftalʹmologiâ

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Cataracts and age-related macular degeneration (AMD) are the leading causes of blindness worldwide. The main symptoms of AMD are: a gradual decrease in visual acuity to the hundredth, metamorphosis, the appearance of a central scotoma, which reduces the quality of life of the patients and leads to disability. Prosthetic and stationary means of optical rehabilitation, such as magnifiers for the visually impaired, glasses, video systems are cumbersome and poorly functional. An alternative correction option is intraocular vision devices that improve the patient’s quality of life. The review considers various types of intraocular implants, in particular, the intraocular telescope system (intraocular miniature telescope-IMT, IOL-VIP, IOL-AMD), Fresnel lens, Lipschitz lens, Scharioth macular lens (Scharioth macula lens, SML), EyeMax Mono, LENTIS ® MAX IOL LS-313 MF80. The use of high-tech devices for the correction of visual disturbances in AMD has opened a new direction in the rehabilitation of low vision. Further study and implementation of the latest generation of “macular” lenses will improve the quality of life of patients with advanced stages of AMD.

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Four Years of Observation to Evaluate Autonomy and Quality of Life after Implantation of a High-Add Intraocular Lens in Age-Related Macular Degeneration Patients

Cited by 6 publications

References 12 publications

Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review

Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review

High-addition segmented refractive bifocal intraocular lens in inactive age-related macular degeneration: A multicenter pilot study

Features of Phacosurgery in Macular Pathology. Part 2. Сapabilities of Optical Correction

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