Four-year clinical update from the American Society of Breast Surgeons MammoSite brachytherapy trial

Nelson, Jonathan C.; Beitsch, Peter D.; Vicini, Frank A.; Quiet, Coral A.; Garcia, Delia M.; Snider, Howard C.; Gittleman, Mark; Zannis, Victor J.; Whitworth, Pat W.; Fine, Richard E.; Keleher, Angela; Kuerer, Henry Mark

doi:10.1016/j.amjsurg.2008.09.016

Cited by 62 publications

(41 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 3-year actuarial rates of ipsilateral breast cancer and axillary recurrences were 2.15% and 0.36%, respectively. Cosmetic outcomes were reported to be acceptable and similar to patients treated with other forms of partial breast irradiation [33]. The advantages of the balloon catheter are that it is easier to place in the cavity, placement is more reproducible, and patient comfort is improved.…”

Section: Cancer Treatment -Conventional and Innovative Approachesmentioning

confidence: 79%

A Review of Radiation Therapy’s Role in Early-Stage Breast Cancer and an Introduction to Electronic Brachytherapy

Herron¹,

Herron²,

Howell³

et al. 2013

Cancer Treatment - Conventional and Innovative Approaches

View full text Add to dashboard Cite

Section: Cancer Treatment -Conventional and Innovative Approachesmentioning

confidence: 79%

A Review of Radiation Therapy’s Role in Early-Stage Breast Cancer and an Introduction to Electronic Brachytherapy

Herron¹,

Herron²,

Howell³

et al. 2013

Cancer Treatment - Conventional and Innovative Approaches

View full text Add to dashboard Cite

“…The 3-year actuarial rates of ipsilateral breast cancer and axillary recurrences were 2.15% and 0.36%, respectively. Cosmetic outcomes were reported to be acceptable and similar to patients treated with other forms of partial breast irradiation [44]. The advantages of the balloon catheter are that it is easier to place in the cavity, placement is more reproducible, and patient comfort is improved.…”

Section: Breast Brachytherapy and Partial Breast Radiationmentioning

confidence: 79%

Radiation Therapy in Early-Stage Invasive Breast Cancer

Lin

Tripuraneni

2011

Indian J Surg Oncol

View full text Add to dashboard Cite

The treatment of breast cancer involves a multi-disciplinary approach with radiation therapy playing a key role. Breast-conserving surgery has been an option for women with early-stage breast cancer for over two decades now. Multiple randomized trials now have demonstrated the efficacy of breast-conserving surgery followed by radiation therapy. With the advancements in breast imaging and the successful campaign for early detection of breast cancer, more women today are found to have early-stage small breast cancers. Patient factors (breast size, tumor location, history of prior radiation therapy, preexisting conditions such as collagen vascular disease, age, having prosthetically augmented breasts), pathological factors (margin status, tumor size, presence of extensive intraductal component requiring multiple surgical excisions), as well as patient preference are all taken into consideration prior to surgical management of breast cancer. Whole-breast fractionated radiation therapy between 5 and 7 weeks is considered as the standard of care treatment following breast-conserving surgery. However, new radiation treatment strategies have been developed in recent years to provide alternatives to the conventional 5-7 week whole-breast radiation therapy for some patients. Accelerated partial breast radiation therapy (APBI) was introduced because the frequency of breast recurrences outside of the surgical cavity has been shown to be low. This technique allows treatments to be delivered quicker (usually 1 week, twice daily) to a limited volume. Often times, this treatment involves the use of a brachytherapy applicator to be placed into the surgical cavity following breast-conserving surgery. Accelerated hypofractionated whole-breast irradiation may be another faster way to deliver radiation therapy following breast-conserving surgery. This journal article reviews the role of radiation therapy in women with early-stage breast cancer addressing patient selection in breast-conserving therapy, a review of pertinent trials in breast-conserving therapy, as well as the different treatment techniques available to women following breast-conserving surgery.Keywords Accelerated partial breast irradiation . Breast brachytherapy . Breast-conserving surgery and radiation . Hypofractionated whole-breast radiation . Breast irradiation in early-stage breast cancer

show abstract

“…A total of 1,449 breasts were treated with the MammoSite Ò applicator during this trial. A 4 year clinical update published in 2009 described 1.9% in-breast recurrence for the entire group and a 2.65% in-breast recurrence for the first 400 patients treated [3]. These were divided into invasive breast cancer and ductal carcinoma in situ.…”

Section: Discussionmentioning

confidence: 98%

Angiosarcoma following MammoSite® partial breast irradiation

Andrews

Wilcoxon

Benda

et al. 2010

Breast Cancer Res Treat

View full text Add to dashboard Cite

Angiosarcoma is a rare tumor of endothelial origin which commonly arises in small blood or lymphatic vessels. Its development in the treated breast following adjuvant external beam radiation is also rare. To our knowledge, there are no reported cases in the literature or MammoSite registry which describe the occurrence of angiosarcoma in the treated breast following MammoSite brachytherapy. This is a case report of a 74 year old female who developed angiosarcoma 4 years after receiving MammoSite balloon brachytherapy following surgical resection of a T1mic N0 M0 infiltrating ductal carcinoma.

show abstract

Four-year clinical update from the American Society of Breast Surgeons MammoSite brachytherapy trial

Cited by 62 publications

References 11 publications

A Review of Radiation Therapy’s Role in Early-Stage Breast Cancer and an Introduction to Electronic Brachytherapy

A Review of Radiation Therapy’s Role in Early-Stage Breast Cancer and an Introduction to Electronic Brachytherapy

Radiation Therapy in Early-Stage Invasive Breast Cancer

Angiosarcoma following MammoSite® partial breast irradiation

Contact Info

Product

Resources

About