Four new recurring translocations in non-Hodgkin lymphoma

Abstract

The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified--t(8;9) (q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22) (q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy- chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.

t(11;18)(q21;q21) may delineate a spectrum of diffuse small B‐cell lymphoma with extranodal involvement

“…and Horsman et al (1992) recently reported a new t( 11; 18) delineating a subtype of diffuse small B-cell lymphoma. In addition to a previous report (Levine et al, 1989), this t(l1;18)(qZl;q21) has been reported in five cases of diffuse small B-cell lymphoma. T h e histologic subtype was lymphocytic in four cases (Levine et al, 1989;Griffin et al, 1992), whereas the case reported by Horsman et al was classified as a MALT lymphoma.…”

“…In addition to a previous report (Levine et al, 1989), this t(l1;18)(qZl;q21) has been reported in five cases of diffuse small B-cell lymphoma. T h e histologic subtype was lymphocytic in four cases (Levine et al, 1989;Griffin et al, 1992), whereas the case reported by Horsman et al was classified as a MALT lymphoma. As detailed histologic descriptions were lacking in the first two cases reported by Levine et al, the Canadian group assumed that these two cases could be related to their own case, and they subsequently questioned the possible association of t(11;18) with MALT (Horsman et al, 1992).…”

Multiple polypoid lesions of primary mucosa‐associated lymphoid‐tissue lymphoma of colon

“…This translocation was rarely detected, and was reported in six cases in the literature, to our knowledge [26][27][28][29] . Three of the six cases were of extranodal origin (two stomach and one lung) [27][28][29] and the other three had extranodal involvement (stomach, bowel and lacrimal gland) 26,29 . The histology of the cases was reported as either MALT lymphoma or small lymphocytic lymphoma; the latter is most likely to be MALT lymphoma by the current concept of lymphoma classification.…”

No evidence of a correlation between BCL10 expression and API2‐MALT1 gene rearrangement in ocular adnexal MALT lymphoma

“…10 Studies have found that the t(11;18)(q21;q21) translocation with expression of an API2-MALT1 chimeric transcript occurred in 18-48% of MALT lymphomas, and was especially frequently detected in pulmonary and gastrointestinal MALT lymphomas, but not in nodal or splenic marginal zone B-cell lymphomas. [11][12][13][14][15][16][17][18][19][20][21] The apoptotic inhibitor 2 (API2) gene on chromosome 11q21 is a member of the inhibitor apoptosis (IAP) gene family with caspase-inhibitor functions, and the MALT1 gene on chromosome 18q21 encodes human paracaspase (caspase-like protein), the function of which remains unclear. 22 The API2-MALT1 fusion product, which activates NFkB, leads to inhibition of apoptosis, thereby promoting tumor cell survival.…”