Four new polyoxygenated gorgosterols from the gorgonian<i>Isis hippuris</i>

Uddin, Mohammad Helal; Hanif, Novriyandi; Trianto, Agus; Agarie, Yutaka; Higa, Tatsuo; Tanaka, Junichi

doi:10.1080/14786419.2010.485303

Cited by 18 publications

(9 citation statements)

References 18 publications

(28 reference statements)

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“…I. hippuris was also the source of polyhydroxylated sterols 1078-1081 (Izena Is., Okinawa) 723 and 1082-1087 (Orchid Is., Taiwan). 724 Sterols 1078-1081 were mildly cytotoxic while 1084 exhibited antiviral activity (human cytomegalovirus).…”

Section: Mild To Moderate Cytotoxicity Was Observed For Lobocrassinsmentioning

confidence: 99%

Marine natural products

et al. 2013

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This review covers the literature published in 2011 for marine natural products, with 870 citations (558 for the period January to December 2011) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1152 for 2011), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Mild To Moderate Cytotoxicity Was Observed For Lobocrassinsmentioning

confidence: 99%

Marine natural products

et al. 2013

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“…Although a large number of compounds from the various groups have been isolated and characterized, those belonging to the hippurin or hippuristanol class exhibit the most potent cytotoxic activity ex vivo against tumor cell lines, underscoring the importance of the spiroketal group for activity. 32,33,[65][66][67] Some members of the gorgosterol class exhibit moderate cytotoxicity 68,69 (IC 50 approximately 2 mM against NBT-T2 rat bladder epithelial cells and approximately 15 mM [for presumably a 4 day exposure period 70 ]) and have shown activity against human epidermoid carcinoma KB drug-resistant cells expressing the drug transporter, ABCB1/P-glycoprotein (approximately 6-10 greater activity than against cells not expressing ABCB1), but less so against cells expressing multidrug resistance protein-1 (MRP1). 68 Tumor cell cytotoxicity has been reported for compounds of the hippuristerone family 66 but these are far less potent than hippurin or hippuristanol-like compounds.…”

Section: Introductionmentioning

confidence: 99%

Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A

Cencic

2016

Translation

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Protein synthesis and its regulatory signaling pathways play essential roles in the initiation and maintenance of the cancer phenotype. Insight obtained over the last 3 decades on the mechanisms regulating translation in normal and transformed cells have revealed that perturbed control in cancer cells may offer an Achilles' heel for the development of novel anti-neoplastic agents. Several small molecule inhibitors have been identified and characterized that target translation initiationmore specifically, the rate-limiting step where ribosomes are recruited to mRNA templates. Among these, hippuristanol, a polyhydroxysteroid from the gorgonian Isis hippuris has been found to inhibit translation initiation by blocking the activity of eukaryotic initiation factor (eIF) 4A, an essential RNA helicase involved in this process. Herein, we highlight the biological properties of this compound, its potential development as an anti-cancer agent, and its use to validate eIF4A as an anti-neoplastic target.

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“…Senyawa turunan steroid hippuristanol dan seskuiterpene dilaporkan berhasil diisolasi dari Green Island, Pantai Tenggara Taiwan (Sheu et al, 2002). Senyawa steroid polioksigenasi dari I. hippuris asal Okinawa, Jepang dilaporkan menunjukkan aktivitas moderat reversal of multidrug resistance (MDR) dengan sel kanker (Tanaka et al, 2002), dan aktivitas moderat sitotoksik terhadap kultur sel NBT-T2 (Uddin et al, 2011). Senyawa steroid polioksigenasi asal Pantai Tenggara Taiwan juga dilaporkan telah diisolasi dari I. hippuris asal Green Island, (Chao et al, 2005) dan Pulau Orchid (Chen et al, 2011).…”

Section: Komponen Bioaktif Total Per Ekstrak Kering Persamaanunclassified

SKRINING KOMPONEN BIOAKTIF EKSTRAK BAMBU LAUT (Isis hippuris) DARI PERAIRAN SULAWESI TENGAH

Muliadin¹,

Dewanto²,

Wahyudi³

et al. 2022

J. Kelaut. Perikan. Terap.

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Bambu laut (Isis hippuris) merupakan salah satu organisme laut penyusun ekosistem terumbu karang yang dilaporkan berpotensi sebagai sumber bahan bioaktif. Bambu laut mengandung bioaktif polioksigenasi steroid, hidrokarbon, fenol dan asam lemak. Penelitian ini bertujuan mengonfirmasi komponen bioaktif dari ekstrak bambu laut. Sampel bambu laut dikoleksi dari perairan Kabupaten Donggala, Sulawesi Tengah, dengan kondisi cuaca cerah. Pada sampel bambu laut dilakukan proses ekstraksi (maserasi MeOH : DCM), skrining komponen bioaktif (metode Harborne), dan determinsi kandungan total alkaloid (ekuivalen kafein - CE), fenol (ekuivalen asam galat - GAE), flavonoid (ekuivalen kuersetin - QE), dan steroid (ekuivalen kolesterol - ChE). Hasil skrining komponen bioaktif menunjukkan ekstrak bambu laut (I. hippuris) mengandung sejumlah komponen alkaloid, fenol, steroid dan flavonoid. Ekstrak bambu laut mengandung alkaloid 11,61 ± 0,24 mg CE.g-1 ekstrak kering; fenol sebesar 18,92 ± 0,24 mg GAE.g-1 ekstrak kering; flavonoid sebesar 21,24 ± 0,28 mg QE.g-1 ekstrak kering; dan steroid sebesar 36.94 ± 1.39 mg ChE.g-1 ekstrak kering. Penelitian ini mengonfirmasi keberadaan komponen bioaktif ekstrak bambu laut (I. hippuris) yang dikoleksi dari perairan Sulawesi Tengah. Hasil skrining komponen bioaktif menunjukkan kehadiran komponen alkaloid, fenol, steroid dan flavonoid. Oleh karena itu, perlu diidentifikasi lebih lanjut senyawa bioaktif (diduga turunan steroid, alkaloid dan fenolik) yang terkandung dari ekstrak bambu laut.

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Four new polyoxygenated gorgosterols from the gorgonianIsis hippuris

Cited by 18 publications

References 18 publications

Marine natural products

Marine natural products

Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A

SKRINING KOMPONEN BIOAKTIF EKSTRAK BAMBU LAUT (Isis hippuris) DARI PERAIRAN SULAWESI TENGAH

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