Four new phorbol diesters from Croton tiglium and their cytotoxic activities

Zhang, Xiaolong; Khan, Ashfaq-Ahmad; Wang, Lun; Yang, Kai; Li, Fu; Wang, Mingkui

doi:10.1016/j.phytol.2016.03.008

Cited by 20 publications

(7 citation statements)

References 11 publications

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“…The twigs and leaves of C. caudatus produced three new tiglianoids, crotusins A–C ( 128 – 130 ) [ 44 ]. Tigliane diterpenoids were abundant in C. tiglium , other 47 new ones ( 93 , 94 , 99 – 106 , 108 – 110 , 112 – 127 , 131 – 148 ) were isolated from C. tiglium [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. Among them, compound ( 112 ) was the first tiglianoid with the C20-aldehyde group [ 48 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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The genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018. A total of 399 new compounds, including 339 diterpenoids, were reported. Diterpenoids are characteristic components of the Croton species. These isolated compounds exhibited a broad spectrum of bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting properties. The present review provides a significant clue for further research of the chemical constituents from the Croton species as potential medicines.

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Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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“…The lower layer was shown to be the active layer for dermal coagulation and inflammation, by concentrating phenol and the active chemicals of Croton tiglium oil, which includes multiple phorbol esters. 5 Thus, with insufficient agitation, the depth of injury could vary between no damage (upper layer) to extremely deep damage of more than 2600 m (2.6 mm) (lower layer). 6 mm]).…”

Section: Because Of Improved Emulsion Stability (Fig 1 A-d Left)mentioning

confidence: 99%

Depth of injury of Hetter's phenol-croton oil chemical peel formula using 2 different emulsifying agents

Justo

Lemes

Nunes

et al. 2020

Journal of the American Academy of Dermatology

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“…Research into the seeds of Croton tiglium (Sichuan, China) afforded four new 4-deoxy-4β-phorbol diesters. Compound 294 was cytotoxic toward SNU387 cell line with an IC 50 value of 0.71 μM (Zhang et al, 2016j ). The seeds of Annona squamosa (Guangdong, China) afforded four new annonaceous acetogenins (ACGs), squamocins I–III ( 295 - 297 ), and squamoxinone D. Compound 297 were most active against H460 cell line with an IC 50 value of 0.0492 μg/mL (Miao et al, 2016 ).…”

Section: Terrestrial Plantsmentioning

confidence: 99%