Four new phenanthrenes from Monomeria barbata Lindl

Yang, Minghui; Cai, Le; Tai, Zhigang; Zeng, Xianghui; Ding, Zhong‐Tao

doi:10.1016/j.fitote.2010.06.019

Cited by 31 publications

(21 citation statements)

References 10 publications

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“…The authors suggested that dimeric and trimeric phenanthrenes might potentially be used as a novel class of antitumor candidates to fight tumor diseases. [68] It is worth to note that a strong limitation of these compounds as potential antitumor agents is given by the poor knowledge on bioavailability, pharmacokinetic, and potential side effects. Due to presence of phenolic groups, the overall bioavailability of such constituents is possibly poor, and this may limit the use of these derivatives as leads for the development of cytotoxic drugs.…”

Section: Phenanthropyrans and Phenanthrenes As Possible Medicinal Agentsmentioning

confidence: 99%

“…Compound 34 showed cytotoxicity on Skov‐3 cell line ( IC 50 41.5 μ m , similar to cisplatin IC 50 37.9 μ m ). The authors suggested that dimeric and trimeric phenanthrenes might potentially be used as a novel class of antitumor candidates to fight tumor diseases . It is worth to note that a strong limitation of these compounds as potential antitumor agents is given by the poor knowledge on bioavailability, pharmacokinetic, and potential side effects.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Secondary Metabolites from Orchids (Orchidaceae)

Sut

Maggi

Dall’Acqua

2017

Chemistry & Biodiversity

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The Orchidaceae family is the largest group of flowering plants in the Angiosperm monocotyledons spread on our planet. Its members, called orchids, are herbs or epiphytes with showy flowers distributed mainly in tropical regions. Several classes of phytoconstituents have been so far isolated from therapeutically-used orchids showing a great chemical diversity. Among them, phenolic derivatives have been studied for their biological activities, especially in the field of cancer, inflammation, and neurodegeneration. On the other hand, limited information has been so far obtained on the numerous alkaloids and terpenoids isolated from several orchid species. Recent articles revealed pronounced effects of some alkaloids on the CNS. Published literature on orchids that are used in traditional medicine has been reviewed in this work indicating a great potential of such organisms as source of chemical entities for the development of new drugs.

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Section: Phenanthropyrans and Phenanthrenes As Possible Medicinal Agentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites from Orchids (Orchidaceae)

Sut

Maggi

Dall’Acqua

2017

Chemistry & Biodiversity

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“…The PE and EtOAc partitions were chromatographed over silica gel, Sephadex LH-20 and ODS columns, and semi-preparative HPLC to obtain eleven biphenanthrenes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) (Figure 1). Their structures were elucidated based on extensive spectroscopic analyses (Supplementary Materials).…”

Section: Resultsmentioning

confidence: 99%

“…The phenanthrenes isolated thus far may be classified into three major groups: monophenanthrenes, biphenanthrenes, and triphenanthrenes, and most natural phenanthrenes occur in monomeric form [1]. To date, less than one hundred biphenanthrenes and two triphenanthrenes have been isolated from the Orchidaceae family [2][3][4][5][6][7][8][9][10][11][12][13]. Biphenanthrenes have been reported to possess various biological activities including cytotoxicity, antimicrobial, spasmolytic, anti-inflammatory, antiplatelet aggregation, and antiallergic activities [1].…”

Section: Introductionmentioning

confidence: 99%

“…Biphenanthrenes have been reported to possess various biological activities including cytotoxicity, antimicrobial, spasmolytic, anti-inflammatory, antiplatelet aggregation, and antiallergic activities [1]. Currently, the cytotoxic activities of biphenanthrenes have attracted much interest, and biphenanthrenes may potentially be served as novel class of antitumor candidate [4].…”

Section: Introductionmentioning

confidence: 99%

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Five New Biphenanthrenes from Cremastra appendiculata

Liu

Zeng

et al. 2016

Molecules

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Five new biphenanthrenes, cremaphenanthrenes A-E (1-5), along with six known ones, were isolated from the ethanolic extract of the tubers of Cremastra appendiculata (D. Don) Makino (Orchidaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses.All the compounds obtained were tested in vitro for cytotoxic activities against colon (HCT-116), cervix (Hela), and breast (MDA-MB-231) cancer cell lines. They all showed moderate or weak cytotoxicities to the above cancer cell lines.

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Known or Never before Identified Phenanthrenes: Where It Is Possible to Isolate Them and Why

Fabio

Zarrelli

2022

Chemistry & Biodiversity

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The secondary metabolites of plant origin belong to different and numerous classes of organic compounds. One of these is that of dimeric phenanthrenes, symmetrical or not, characterized by a series of interesting biological activities. Of these compounds, 37 have been isolated since 1988, from only five plant families. Considering each dimer comprises two phenanthrenes and starting from the hypothesis that each dimer is obtained through a biosynthetic mechanism that involves the coupling of the corresponding radicals of the individual phenanthrene units, it is possible to identify 29 phenanthrenes, of which 6 not yet isolated. It is possible to establish that 16 known phenanthrenes can be isolated from 14 different plant species, just as 6 new phenanthrenes can be isolated from 6 different plant species. This would allow a targeted analysis of a few natural extracts from specific plant sources to identify known or new molecules, with potential and/or specific biological activities.

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Four new phenanthrenes from Monomeria barbata Lindl

Cited by 31 publications

References 10 publications

Bioactive Secondary Metabolites from Orchids (Orchidaceae)

Bioactive Secondary Metabolites from Orchids (Orchidaceae)

Five New Biphenanthrenes from Cremastra appendiculata

Known or Never before Identified Phenanthrenes: Where It Is Possible to Isolate Them and Why

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