Four new hybrid polyketide-terpenoid metabolites from the Penicillium sp. SYPF7381 in the rhizosphere soil of Pulsatilla chinensis

Qi, Feng; Yu, Ying; Tang, Ming-Xu; Zhang, Tianyuan; Zhang, Mengyue; Wang, Haifeng; Han, Yueqing; Zhang, Yixuan; Chen, Gang; Pei, Yue‐Hu

doi:10.1016/j.fitote.2018.01.010

Cited by 25 publications

(19 citation statements)

References 18 publications

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“…Though there are reports of secondary metabolites with antitumor activity from Penicillium sp. (Bladt et al 2013;Chavez et al 2015;Nicoletti and Trincone 2016;Feng et al 2018;Farha and Hatha 2019;Orfali and Perveen 2019), a metabolite from P. rubens having promising anticancer properties has been reported for the first time in this present work.…”

Section: Discussionmentioning

confidence: 53%

Modulation of Bax and Bcl-2 genes by secondary metabolites produced byPenicillium rubensJGIPR9 causes the apoptosis of cancer cell lines

Venkatachalam

Nadumane

2019

Mycology

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Search for an efficient anti-cancer compound of natural origin with well-defined mechanisms of action is an important scientific pursuit today, due to cancer being the second leading cause for the death of affected people. The members of the genus Penicillium are one of the important sources of bioactive compounds. In the present study, Penicillium rubens, isolated from a garden soil in Madurai district of Tamil Nadu, was found to produce a highly promising anti-cancer metabolite. The percentage viabilities of HepG2, HeLa and MCF-7 cancer cells treated with the bioactive fraction (P5) isolated from P. rubens, ranged between 40-50% after 96 h. Apoptosis induction was found to be the major reason for the observed reduction in cancer cell proliferation and cell count which was confirmed by caspase activity, DNA fragmentation, clonogenic assay, cell cycle analysis and LDH assays. The upregulation of proapoptotic Bax, coupled with the downregulation of anti-apoptotic Bcl-2 expressions were confirmed by RT-qPCR and flow cytometry methods. The current study also indicated an upregulation of p53 which further strengthened the apoptogenic property of P5 fraction. Non-toxicity of P5 was demonstrated on normal peripheral lymphocytes. The analysis of P5 fraction through GC-MS indicated the presence of indole-2, 3-(4,4-dimethyl-3-thiosemicarbazone) as one of the major compounds. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 53%

Modulation of Bax and Bcl-2 genes by secondary metabolites produced byPenicillium rubensJGIPR9 causes the apoptosis of cancer cell lines

Venkatachalam

Nadumane

2019

Mycology

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“…This assay was performed according to our previous method 37 . Briefy, the crystal structure of protein obtained from RCSB Protein Data Bank (PDB Code 3VOB) were used for docking 51 . The 3D structures of the compounds 1–2 and 5 were prepared and Gasteiger-Hückel charges were added using Sybyl software (Tripos, America).…”

Section: Methodsmentioning

confidence: 99%

“…The 3D structures of the compounds 1–2 and 5 were prepared and Gasteiger-Hückel charges were added using Sybyl software (Tripos, America). The ligand, guanosine-5′-diphosphate, was subjected to energy minimization with Tripos force filed parameters 51 . Blind docking was carried out using Molegro Virtual Docker 4.0 (Molegro ApS, Aarhus, Denmark) program.…”

Section: Methodsmentioning

confidence: 99%

New antimicrobial compounds produced by Seltsamia galinsogisoli sp. nov., isolated from Galinsoga parviflora as potential inhibitors of FtsZ

Zhang

et al. 2019

Sci Rep

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A total amount of 116 fungal strains, belonging to 30 genera, were acquired from the rhizosphere soil and plant of Galinsoga parviflora . A strain SYPF 7336, isolated from the rhizospheric soil, was identified as Seltsamia galinsogisoli sp. nov., by morphological and molecular analyses, which displayed high antibacterial activity. In order to study the secondary metabolites of Seltsamia galinsogisoli sp. nov., nine compounds were successfully seperated from the strain fermentation broth, including two new compounds and seven known compounds. Their structures were elucidated based on spectral analysis including 1D and 2D NMR. All the seperated compounds were evaluated for their antimicrobial activities. Compounds 2, 5 and 1 displayed antimicrobial activities against Staphylococcus aureus with MIC values of 25, 32 and 75 μg/mL, respectively. Moreover, morphological observation showed the coccoid cells of S. aureus to be swollen to a volume of 1.4 to 1.7-fold after treatment with compounds 1 , 2 and 5 , respectively. Molecular docking was carried out to investigate interactions of filamentous temperature-sensitive protein Z (FtsZ) with compounds 1 , 2 and 5 .

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“…DWS10-P-6 was obtained from a sample collected in soil from Yunnan Province, China. Our further study of this fungus resulted in the isolation of two new xanthones (1-2) and two new anthraquinones (3)(4), together with twelve known compounds. The known compounds were identied as oxisterigmatocystin C (5), 8 demethylsterigmatocystin (6), 9 sterigmatocystin (7), 10 versiconal acetate (8), 11 versicolorin B (9), 12 nidurun (10), 13 8-O-methylaverun (11), 14 averythrin (12), 15 3,7-dihydroxy-1,9-dimethyldibenzofuran (13), 16 3,3 0 -O-dimethylviolaceol-I (14), 17 diorcinol (15) 17 and alternariol (16).…”

Section: Introductionmentioning

confidence: 99%

“… 1,2 Penicillium is among the most studied fungi and has been reported to produce many leading compounds, 3 such as penicillin and griseofulvin. Particularly noteworthy is that many previously undiscovered natural products continue to be found within the genus Penicillium including xanthone and anthraquinone derivatives, 4 such as penexanthone A, 5 2′-acetoxy-7-chlorocitreorosein, 6 and emodacidamides A–H, 7 which were isolated from Penicillium sp., possessing antitumor, antibacterial and immunoregulatory activities respectively.…”

Section: Introductionmentioning

confidence: 99%

Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6

et al. 2021

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Four new hybrid polyketide-terpenoid metabolites from the Penicillium sp. SYPF7381 in the rhizosphere soil of Pulsatilla chinensis

Cited by 25 publications

References 18 publications

Modulation of Bax and Bcl-2 genes by secondary metabolites produced byPenicillium rubensJGIPR9 causes the apoptosis of cancer cell lines

Modulation of Bax and Bcl-2 genes by secondary metabolites produced byPenicillium rubensJGIPR9 causes the apoptosis of cancer cell lines

New antimicrobial compounds produced by Seltsamia galinsogisoli sp. nov., isolated from Galinsoga parviflora as potential inhibitors of FtsZ

Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6

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